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BROWN, J. C., MUTT, V., and DRYBURGH, J. R. 1971. The further purification of motilin, a gastric motor activity stitnulating polypeptide from the mucosa of the small intestine of hogs. Can. J. Physiol. Pharmacol. 49,[399][400][401][402][403][404][405] A polypeptide has been isolated from the duodenal mucosa of hogs and has been named motilin. Motilin stimulates motor activity in both antral and fundic gland area pouches of the stomach of dogs. Pt will stimulate pepsin output, with no change in H' secretion, from fundic gland area pouches. Motilin differs from the other characterized gastrointestinal polypeptides both chemically and in its physiological actions. In particular, the presence of phenylalanine as N-terminal residue, the absence of histidine, and presence of large amounts of glutamic acid and glutamine distinguish it from cholecystokinin-pancreozymin and secretin. BROWN, b. C., MUTT, V.. et DRYRURGII. J . W. 1971. The further purification of motilin, a gastric motor activity stinmulating polypeptide from the nmucosra of the small intestine of hogs. Can. J. Physiol. Pharnmacol. 49, 399-4135.Wous avons is016 B partir de la muqueuse duodenale de porc. un polypeptide que nous avons nomrnk motiline. I1 stimufe la motilitC des poches de I'antre pylorique et du fundus de l'estornac de chien. I1 stirnule kgalernent la libkration de pepsine sans motifier la skcrbtion d'H+ B partir des aires ~Ccrbtrices du fundus. La motiline diffhre des autres polypeptides gastro-intestinaux dbjB connus par caractCristiques chimiques et ses actions physiologiques. En particulier. les caract2res qui le distinguent de la s@cr@tine et du CCK-PZ sont la prCsence de phbnylalanine csmme rksidu N-terminal, l'ahsence d'histidine et l'abondance de glutamine et d'acide glutanmique.

Recently Tatemoto, Mutt and colleagues (1982) have discovered a hexatriacontapeptide amide,

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