Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids

Sen, Tuhinadri; Salam, C.A Abdul; Pal, Subhajit; Sen, Suchandra; Chaudhuri, Arabinda

doi:10.1016/s0024-3205(00)00561-0

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…The present study also revealed that amitriptyline possessed stronger antiulcer activity than dothiepin [5] in the indomethacin, alcohol and cold restraint stress models. Similarly, in pyloric-ligated rats, amitriptyline gave more effective control of pH, total acidity and protein content than dothiepin [5].…”

Section: Discussionsupporting

confidence: 71%

“…In an earlier study in our laboratory with dothiepin, we showed that the antiulcer activity of dothiepin may be attributable to interference of the drug with either the 5‐lipoxygenase pathway or lipid‐derived eicosanoids [5]. The present study was designed to assess the antiulcer effect of amitriptyline on various models of gastrointestinal (GI) ulceration, where lipid‐derived eicosanoids are known to play a predominant role in the process of ulcerogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Antiulcer studies with antidepressant drugs have revealed that several tricyclic antidepressant drugs, such as trimipramine [3], clotiazepam [4] and dothiepin [5], possess significant antiulcer activity against different types of ulcer models.…”

Section: Introductionmentioning

confidence: 99%

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Effect of amitriptyline on gastric ulceration

Sen

Abdulsalam

Pal

et al. 2002

Fundamemntal Clinical Pharma

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Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric-ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Effect of amitriptyline on gastric ulceration

Sen

Abdulsalam

Pal

et al. 2002

Fundamemntal Clinical Pharma

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Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue

et al. 2009

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BackgroundAlthough many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants.MethodsGroups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate groups of rats were treated with the same doses of fluvoxamine and ranitidine, but not with indomethacin, to test effects of these drugs alone on biochemical parameters. The stomachs were evaluated biochemically to determine oxidant and antioxidant parameters. We used one-way ANOVA and least significant difference (LSD) options for data analysis.ResultsThe 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group.ConclusionWe conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

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İndometazin İle İndüklenerek Oluşturulan Gastrik Ülsere Karşı Propolisin Etkinliğinin Belirlenmesi

KORKMAZ,

TABUR

2023

Erciyes Tarım Ve Hayvan Bilimleri Dergisi

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İndometazin; indol türevi, non-steroid antienflamatuvar bir ajan olan paraklorobenzoil-metoksi-metilindol-asetik asidin genelde kullanılan ismidir. İndometazin’in antienflamatuvar etkilerinin yanı sıra, analjezik ve antipiretik etkileri de bulunan kimyasal bir ajan olarak kabul edilmektedir. İndometazin’in olumlu etkileri dikkate alındığında; küçük hücreli olmayan akciğer kanserinin büyümesini baskıladığı, insanlarda meme kanser hücresinin metastaz ve invazyonunu azalttığını söylemek mümkündür. İmmün cevabı geliştirmesinin yanı sıra, apoptotik hücre ölümünü artırdığı yapılan bilimsel çalışmalarla tespit edilmiştir. Son yıllarda özellikle, korona virüs replikasyonunu inhibe etmede, İndometazin’in etkili olduğu görülmüştür. Ayrıca, İndometazin hiperbarik oksijenasyonda görülen konvülsiyonları hafifletir ve hiperemi oluşumunu önlemektedir. İndometazin’in olumsuz etkileri ele alındığında, bu kimyasal ajanın yanlış dozlanması sonucunda en yaygın olarak gözlenen yan etkisi mide ülseri şeklinde kendini göstermektir. İndometazin’in anti-enflamatuvar etkisinden COX–2, gastrointestinal toksik etkilerinden ise COX–1 enzim inhibisyonu sorumlu tutulmaktadır. İndometazin hem COX–1 hem de COX–2 enzimlerini inhibe ederek, prostaglandin sentezini güçlü bir şekilde engeller. Bu nedenledir ki indometazinin ülser oluşturma oranı diğer nonsteroid antienflamatuvar ilaçlara göre çok daha yüksek olduğundan, deneysel ülser modeli oluşturmak amacı ile daha çok tercih edilmektedir. Oluşturulan bu mide ülseri modelleri tedavisinde kimyasalın yanı sıra bitkisel ve hayvansal ürünlerde yaygın olarak kullanılmaktadır. “Tıbbi bitkilerin ve hayvansal ürünlerin canlı sistemler üzerinde; sedatif, analjezik, antipiretik, antiülseratif, kardiyoprotektif, antibakteriyel, antifungal ve antiviral gibi birçok etkisi çalışmalarla ortaya konulmuştur.” Bitkiler, serbest radikalleri nötralize ederek, oksidatif stres ve reaktif oksijen türleri ile bağlantılı birçok kronik hastalığın ilerlemesini önlemektedir. Propolisin anti-bakteriyal, anti-fungal ve anti-ülseratif etkilerinden yaygın olarak faydalanıldığı göze alındığında mide ülseri üzerine de düzenli tüketimle olumlu etkileri olabileceği düşünülmektedir. Bu çalışma ile Propolis’in mide ülseri üzerindeki etkileri teorik olarak ele alınarak ilgili literatüre katkı sağlanması hedeflenmektedir.

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Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids

Cited by 3 publications

References 16 publications

Effect of amitriptyline on gastric ulceration

Effect of amitriptyline on gastric ulceration

Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue

İndometazin İle İndüklenerek Oluşturulan Gastrik Ülsere Karşı Propolisin Etkinliğinin Belirlenmesi

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