Effect of amitriptyline on gastric ulceration

Sen, Tuhinadri; Abdulsalam, C. A.; Pal, Subhajit; Sen, Suchandra; Karmakar, Subrata; Saravanan, K.; Chaudhuri, Arabinda

doi:10.1046/j.1472-8206.2002.00092.x

Cited by 19 publications

(14 citation statements)

References 20 publications

(25 reference statements)

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“…Apart from these factors, depression with psychotic and somatic symptoms has been seen in patients with GIS disease [10]. Clinical studies on this issue have demonstrated that anxiolytic and antidepressant drug therapy is useful in ulcerative patients with depression [11]. Because antidepressant drugs are useful for clinical ulcer treatment, one may think that ulcer pathogenesis is particularly connected with depression.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

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Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods:The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results:Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group. Conclusion:It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms.

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Section: Introductionmentioning

confidence: 99%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

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“…34) Sen et al suggested that amitriptyline's antiulcer eŠect might be attributable to LoAZ inhibition in indomethacin-induced ulcers, leucotriene ( LT ) blockade and 5-LoAZ inhibition in ethanol-induced ulcers, and central and peripheral anti-LT activity in cold-stress-induced ulcers. 32) Many experimental studies have shown that antidepressant drugs elicit antiulcer eŠects by reducing histamine secretion from mast cells, inhibiting gastric acid secretion, and blocking LT (LTC 4 , D 4 , and E 4 ) receptors. 32,35) Apart form these factors and mechanisms, other studies have shown that the important primary factor in indomethacin-induced gastric damage is the reactive oxygen species (ROS) mediated lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

“…32) Many experimental studies have shown that antidepressant drugs elicit antiulcer eŠects by reducing histamine secretion from mast cells, inhibiting gastric acid secretion, and blocking LT (LTC 4 , D 4 , and E 4 ) receptors. 32,35) Apart form these factors and mechanisms, other studies have shown that the important primary factor in indomethacin-induced gastric damage is the reactive oxygen species (ROS) mediated lipid peroxidation. 36) Also several antidepressants such as tricyclic antidepressants, tiyaneptine and mirtazapine have been reported to exert antioxidative eŠect.…”

Section: Discussionmentioning

confidence: 99%

“…30) In many studies, antidepressant drugs, particularly tricyclic antidepressants, have been used to decrease gastric acid secretion and as an ulcer treatment 16,31 33) Eicosanoids have been reported to play an important role in ulcerogenesis in various ulcer models (e.g., indomethacin, ethanol, and cold stress). 32) Inhibition of the cyclooxygenase (COX) enzyme causes excessive production of lypooxygenase (LoAZ) products. 34) Sen et al suggested that amitriptyline's antiulcer eŠect might be attributable to LoAZ inhibition in indomethacin-induced ulcers, leucotriene ( LT ) blockade and 5-LoAZ inhibition in ethanol-induced ulcers, and central and peripheral anti-LT activity in cold-stress-induced ulcers.…”

Section: Discussionmentioning

confidence: 99%

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Gastroprotective and Antioxidant Effects of Opipramol on Indomethacin-induced Ulcers in Rats

et al. 2009

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Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer eŠects, but there are presently no data in the literature speciˆcally concerning the antidepressant opipramol. This study aimed to investigate the antiulcer eŠects of opipramol and to determine its potential relationship with oxidant and antioxidant systems. The antiulcer activities of 25, 50 and 100 mg/kg opipramol have been investigated on indomethacin-induced ulcers in rats. Compared with a control group (indomethacin alone), opipramol decreased indomethacin-induced ulcers signiˆcantly at all doses used (52％, 71％ and 76％ respectively). Opipramol also signiˆcant-ly increased the glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels in the stomach tissue, all of which were decreased in the control group given only indomethacin. All doses of opipramol also signiˆcantly decreased myeloperoxidase (MPO), malondialdehyde (MDA) and catalase (CAT) levels in stomach tissue compared to the control. In conclusion, the activation of enzymatic and non-enzymatic antioxidant mechanisms, as well as the inhibition of some toxic oxidant mechanisms, appear to play a role in the antiulcer eŠect of opipramol. This new indication for opipramol prompts a rethinking about the possible clinical application of opipramol, particularly for peptic ulcer patients also presenting depression.

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“…However, postmortem interpretation of chronic abuse and related physical disorders is often very difficult due to a lack of specific findings. Previous studies showed various pathological findings in drug abusers, which included cardiopulmonary abnormalities [1], myocardial hypertrophy [2] and cerebral hemorrhage [3] in amphetamine abusers and gastric ulcers [4], atrophy of the hippocampus [5] and brainstem ischemia [6] in psychotropic drug abusers. However, there appears to be few investigations of the human endocrine system in drug abusers from a medicolegal aspect [7].…”

Section: Introductionmentioning

confidence: 99%

Increase in clusterin-containing follicles in the adenohypophysis of drug abusers

et al. 2006

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The hypothalamic-pituitary-adrenocortical (HPA) system in drug abusers may be affected due to disorders of the hypothalamic dopaminergic system. The present study investigated alterations in the adenohypophysis of middle-aged drug abusers (40-60 years of age), using clusterin-containing mixed cell-follicles as the indicator, in which clusterin (apolipoprotein J) is a multifunctional glycoprotein related to neurodegeneration. The paraffin-embedded adenohypophyses of methamphetamine and psychotropic drug abusers (n = 76) were compared with those of non-abusers (n = 82). The number of follicles was larger in drug abusers independent of the immediate cause of death, although the size was not significantly different. When cell types forming the follicles were immunohistochemically examined, drug abusers showed an increase of prolactin (PRL) cells and gonadotroph cells and a reciprocal decrease of growth hormone cells, suggesting hypofunction of dopaminergic neurons in the hypothalamus, while there was no change in the adrenocorticotropic hormone and thyroid-stimulating hormone cells. These increases of the clusterin-containing follicles and PRL cells in the follicles may be related to the dysfunction of dopaminergic neurons in the hypothalamus of chronic drug abusers and may be useful for investigating drug abuse in forensic casework.

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Effect of amitriptyline on gastric ulceration

Cited by 19 publications

References 20 publications

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Gastroprotective and Antioxidant Effects of Opipramol on Indomethacin-induced Ulcers in Rats

Increase in clusterin-containing follicles in the adenohypophysis of drug abusers

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