Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue

Abstract

BackgroundAlthough many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants.MethodsGroups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate groups of rats were treated with the same doses of fluvoxamine and ranitidine, but not with indomethacin, to test effects of these drugs alone on biochemical parameters. The stomachs were evaluated biochemically to determine oxidant and antioxidant parameters. We used one-way ANOVA and least significant difference (LSD) options for data analysis.ResultsThe 25, 50, 100 and 200 mg/kg doses of fluvoxamine exerted antiulcer effects of 48.5, 67.5, 82.1 and 96.1%, respectively, compared to the control rat group. Ranitidine showed an 86.5% antiulcer effect. No differences were observed in the absence of indomethacin treatment for any dose of fluvoxamine or for ranitidine. The levels of antioxidant parameters, total glutathione and nitric oxide, were increased in all fluvoxamine groups and in the ranitidine group when compared with the indomethacin-only group. In addition, fluvoxamine and ranitidine decreased the levels of the oxidant parameters, myeloperoxidase and malondialdeyhyde, in the stomach tissues of the rats when compared to indomethacin group.ConclusionWe conclude that fluvoxamine has antiulcer effects, and that these occur by a mechanism that involves activation of antioxidant parameters and inhibition of some toxic oxidant parameters.

Gastro Protective and Antioxidant Effect of Euphorbia Prostrata Against Indomethacin Induced Gastric Ulcers in Healthy Adult Male Albino Rabbits

“…This result showed that E. prostratahas gastroprotective effect. Our results coinside with may other studies [33][34][35] . In addition to ulcer parameters different types of biochemical parameters or oxidative health biomarkers were also determined in the present study including total oxidant status, malondialdehyde, total antioxidant capacity and CAT were also determined in the current study.…”

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

“…Although reports have demonstrated that SSRI are associated with increased gastrointestinal bleeding (Dalton et al 2003), many anti-depressant drugs, including SSRI, have been shown to impart anti-ulcer activity in various models of experimental ulcer (Dursun et al 2009;Ji et al 2012). In the study here, pretreatment with fluoxetine significantly prevented mucosal ulcerations induced by INDO and alcohol.…”

Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats

“…Absorption was measured at 412 nm using a spectrophotometer. The GSH levels in the gastric mucosa were expressed as nmol/mg tissue [18].…”