Effect of dopamine on pancreatic secretion in the dog

Abstract

Summary1. Effects of L-dopa and dopamine on the secretion of pancreatic juice were investigated in preparations of the isolated blood-perfused canine pancreas.2. Dopamine (1-10 ,ug) given intra-arterially caused a profuse flow of juice.3. The secretory activity of dopamine (3 ,ug) was approximately equal to that of secretin (01 unit).4. L-Dopa (10-100 [Lg) given by a single intra-arterial injection was ineffective, but infusion at 100 ,ug/min for 10 min caused a marked increase of secretion after a delay of a few minutes.5. Intravenous administration of either L-dopa (3 mg/kg) or dopamine (10-100 ,ug/kg) elicited a marked increase of pancreatic secretion, but was definitely less effective than intra-arterial injection. 6. Dopamine-induced secretion was not modified by atropine, phentolamine, propranolol, guanethidine or tetrodotoxin. 7. It is concluded that dopamine acts directly on the exocrine cells in the pancreas.

Effect of acetazolamide on the secretion of pancreatic juice induced by dopamine in dogs.

“…Dopamine in doses of 1, 3 or 10 dig i.a. caused a prompt increase in the secretion of pancreatic juice, as reported previously (4).…”

“…Previously we reported that dopamine produced marked increases in the secretion of pancreatic juice in the dog (4,5). The responses to dopamine were modified by haloperidol, a dopamine receptor antagonist (6).…”

“…Hashimoto et al (4) reported that dopamine caused an increase in the secretion of pancreatic juice. The mode of action was found to be quite similar to that of secretion, that is a large volume of juice with a higher concentration of bicarbonate were produced (5).…”

“…Details of the preparation have been described elsewhere (4,6). The rate of pancreatic secretion was measured using a drop counter.…”

Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by l‐DOPA and by dopamine in dogs

“…Polyethylene cannulae were inserted into the gastroduodenal and the splenic arteries through which the pancreas was perfused with the animal's own blood from the left femoral artery by means of a Harvard peristaltic pump (Model 500-1200). The details of the preparation were described in a previous paper (Hashimoto et al, 1971). All experiments were performed under constant pressure at 100 mmHg (1 mmHg-1.333 mbar).…”