Summary1. Effects of inhibitors of DOPA decarboxylase, dopamine 8-hydroxylase and monoamine oxidase, and haloperidol on the secretion of pancreatic juice induced by L-DOPA and dopamine were studied in preparations of the isolated blood-perfused canine pancreas. 2. The increased secretion induced by the infusion of L-DOPA (100 ,ug/min) was completely antagonized by Ro 4-4602 (300 ug), a DOPA decarboxylase inhibitor. 3. The secretogogue effect of dopamine (1-10 ug) intra-arterially was not affected by Ro 4-4602, but was enhanced by the infusion of fusaric acid (100
Abstract-Sodium polyacrylate (PANa) is a water-soluble, high-molecular compound, and its aqueous solution shows a very high viscosity and stringiness.In the present study, preventive effects of PANa on three kinds of esophageal lesions induced by gastric juice were examined in comparison with those of aceglutamide aluminium and sodium alginate.
1 Effects of catecholamines given intravenously on exocrine secretion from the pancreas were investigated in anaesthetized rats. The flow rate of pancreatic juice under resting conditions was 11.1 + 3.2pl per hour in 100 animals.2 Dopamine (0.3-3 mg/kg) and isoprenaline (1-10 pg/kg) induced almost the same increase in the pancreatic secretion, so that dopamine was 300 times less potent than isoprenaline. The relative potency of the two amines for stimulation of pancreatic secretion was equivalent to that for fl-stimulation of the contractile force of the left ventricle in vivo. 3 Propranolol (0.5 mg/kg) antagonized completely the dopamine-and isoprenaline-induced stimulation of the pancreatic secretion. 4 Haloperidol (10 mg/kg) failed to suppress the secretory effect of dopamine on the exocrine pancreas but abolished the dopamine-induced hypotension. 5 The dopamine-induced secretion was not modified by atropine (3 mg/kg), phenoxybenzamine (3 mg/kg), vagotomy or pithing. 6 Adrenaline and noradrenaline (10 pg/kg) induced secretion after phenoxybenzamine treatment (3 mg/kg).7 It is suggested that the rat pancreas has a stimulatory f,-adrenoceptor mechanism of exocrine secretion.
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