Effect of acetazolamide on the secretion of pancreatic juice induced by dopamine in dogs.

Iwatsuki, Kazuhiko; Chiba, Shigetoshi

doi:10.1254/jjp.31.292

Cited by 1 publication

(1 citation statement)

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“…Furthermore, Kanno & Yamamoto 0977) suggested that the secretory function of the ductular cells might depend on the bicarbonate ion but not on the calcium ion. Lowering the concentration of bicarbonate ions by treatment with a carbonic anhydrase inhibitor, acetazolamide, inhibited the secretion of pancreatic juice induced by dopamine (Iwatsuki & Chiba, 1981). Verapamil is a potent calcium antagonist (Fleckenstein et al, 1%8, 1%9) and reduces calcium uptake in &cells of the islets (Malaisse et al, 1977), and in smooth muscle cells (Mayer et a]., 1972; Frey & Janke, 1975).…”

Section: Discussionmentioning

confidence: 99%

Effects of Verapamil on Pancreatic Exocrine Secretion Induced by Dopamine, Secretin and Pancreozymin in the Dog

Iwatsuki¹,

Ikeda²,

Chiba³

1982

Clin Exp Pharmacol Physiol

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1. The effects of verapamil on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated, blood-perfused canine pancreas in vivo. 2. The volume of pancreatic secretion either in the resting state or induced by pancreozymin given intra-arterially (i.a.) was decreased by an infusion of 5 micrograms/min of verapamil; that induced by dopamine or secretin i.a. was also decreased but the changes were not statistically significant. 3. Protein concentration in pancreatic juice either in the resting state or in that of stimulated secretion by pancreozymin was decreased significantly, but protein concentration induced by dopamine or secretin was not affected, by verapamil treatment. 4. Verapamil had no effect on bicarbonate concentration in pancreatic juice secreted either in the resting state or when stimulated by these secretagogues.5. These results suggest that verapamil, at least in part, may affect the secretory mechanisms of acinar cells but not that of the ductular cells.

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Section: Discussionmentioning

confidence: 99%