Effect of different non-conventional extraction methods on the antibacterial and antiviral activity of fucoidans extracted from Nizamuddinia zanardinii

Alboofetileh, Mehdi; Rezaei, Masoud; Tabarsa, Mehdi; Rittá, Massimo; Donalisio, Manuela; Mariatti, Francesco; You, SangGuan; Lembo, David; Cravotto, Giancarlo

doi:10.1016/j.ijbiomac.2018.11.201

Cited by 123 publications

(100 citation statements)

References 46 publications

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“…Improved yield achieved by UAE in comparison to CE is attributed to the bubble cavitation phenomenon generated by ultrasonic waves [75], that was previously observed in fucoidan extraction from Sargassum witghtii [70], Undaria pinnatifida [76] and laminarin extraction from A. nodosum and Laminaria hyperborean [75]. No statistical difference between UAE and CE was reported in fucoidan extraction from N. zanardinii [64] and Fucus evanescens [77], while Okolie et al [65] reported significantly higher yield by CE (11.9%) than by UAE (4.56%) and also no statistical differences between UAE, MAE and EAE. Alboofetileh et al [74] compared UAE, EAE and combined UAE-EAE for isolation of polysaccharides from N. zanardinii.…”

Section: Ultrasound Assisted Extraction (Uae)mentioning

confidence: 70%

“…Fucoidan extracted by MAE at 90 • C had similar DPPH scavenging effect and even higher reducing power than fucoidan extracted by CE [55]. At 2 mg/mL MAE polysaccharides inhibited the growth of Escherichia coli although showed lower inhibitory activity against HSV-2 strain [64].…”

Section: Advanced Extraction Techniquesmentioning

confidence: 93%

“…Polysaccharides obtained by MAE have higher concentration of sulfate groups and lower MW [65,66]. Alboofetileh et al [64] reported higher sulfate content and higher MW while Yuan and Macquarrie [55] reported lower sulfate content and lower MW of the polysaccharides extracted by MAE compared to HWE. MAE had no significant effect on type of glycosidic bond and monosaccharide compositions in fucoidan from Sargassum thunbergii [66] while higher fucose content was reported for A. nodosum and N. zanardinii fucoidan [55,64,65] as well as lower uronic acid content [55,64,65].…”

Section: Advanced Extraction Techniquesmentioning

confidence: 99%

“…Alboofetileh et al [64] confirmed that MAE is more efficient than conventional HWE of polysaccharides from Nizamuddinia zanardinii with extraction yields being 6,17% vs. 5,2%, respectively. Higher crude extract yield can be correlated to higher amount of bioactive compounds, but there is a possibility that it is a result of higher amount of impurities [65] which can explain higher yields obtained by CE compared to MAE in other research [55,65].…”

Section: Advanced Extraction Techniquesmentioning

confidence: 99%

“…Among the novel techniques, UAE is the most practical for the industrial level because of its simplicity, faster extraction rate, increased yield as well as reduced cost and processing time [70]. UAE can also be combined with other non-conventional technologies, such as enzymatic processing [71] or MAE [64]. The acoustic cavitation in UAE generates physical forces such as shear, shockwaves, micro jets and acoustic streaming [72], causing cell walls disruption, particle size reduction and better contact between solvent and target compounds.…”

Section: Ultrasound Assisted Extraction (Uae)mentioning

confidence: 99%

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Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.(APS) is determined by algae species however it is also influenced by other factors causing inter-species variation, e.g., growth location and harvesting season [8]. Vast structural variation between the APS therefore presents a challenge in terms of pre-treatments application, extraction techniques and optimization, characterization of isolated fractions and determination of their biological properties.Chemical structure and yield of APS isolated from marine macroalgae by conventional extraction (CE) techniques can be affected by various experimental conditions (pH, time, temperature, pressure, particle size, solvent, sample to solvent ratio, agitation speed etc.). In addition, different advanced techniques such as microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), pressurized liquid extraction (PLE), enzyme-assisted extractions (EAE) are assessed and applied for APS extraction [9][10][11].In general, the chemical structure of polysaccharides determines its physical, chemical and biochemical properties as well as its biological activities [12]. Several studies have reported that their biological activity is strongly associated with their chemical structure [9]. Due to very complex mechanisms that are affected by many factors, the correlation between polysaccharide structure and biological activity is still not sufficiently clarified.In order to improve isolation of APS, pre-treatments are usually applied to the algal biomass prior to the extraction process with the two aims: (i) to prevent co-extraction of interfering bioactive compounds with similar solubility; and (ii) to disrupt cell walls and improve mass transfer of APS into extraction solvent. The first type of pre-treatments is therefore used to remove compounds which are highly bound to the APS such as proteins, phenols and lipids, as well as mannitol and chlorophyll [13]. For that purpose, the application of various pr...

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Section: Ultrasound Assisted Extraction (Uae)mentioning

confidence: 70%

Section: Advanced Extraction Techniquesmentioning

confidence: 93%

Section: Advanced Extraction Techniquesmentioning

confidence: 99%

Section: Advanced Extraction Techniquesmentioning

confidence: 99%

Section: Ultrasound Assisted Extraction (Uae)mentioning

confidence: 99%

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Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

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Infectious diseases caused by viruses are a global health concern and have become prominent in light of the recent COVID‐19 pandemic. Considering the limitations of drugs and prophylactic methods used in current medicine, antiviral materials are a useful strategy in preventing the spread of viruses and enhancing treatment efficiency. Thus, this review highlights the state‐of‐the‐art antiviral materials, describes the scientific landscape of the primary antiviral materials used based on bibliometric analysis, presents their mechanisms of action, and discusses their clinical applications. The mechanisms of action underlying the broad‐spectrum antiviral properties of metals, ceramics, polymers, and composites are also discussed. Polyanions, polycations, oxides, and metal‐based materials, from bulk to nanoparticles, have good potential in antiviral applications that may help prepare the world for future viral breakouts.

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Potential of algal metabolites for the development of broad‐spectrum antiviral therapeutics: Possible implications in COVID‐19 therapy

Sangtani

Ghosh

Jha

et al. 2020

Phytotherapy Research

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Covid‐19 pandemic severely affected human health worldwide. Till October 19, 2020, total confirmed patients of COVID‐19 are 39,944,882, whereas 1,111,998 people died across the globe. Till to date, we do not have any specific medicine and/or vaccine to treat COVID‐19; however, research is still going on at war footing. So far vaccine development is concerned, here it is noteworthy that till now three major variants (named A, B, and C) of severe acute respiratory syndrome‐coronavirus2 (SARS‐CoV‐2) have been recognized. Increased mutational rate and formation of new viral variants may increase the attrition rate of vaccines and/or candidate chemotherapies. Herbal remedies are chemical cocktails, thus open another avenue for effective antiviral therapeutics development. In fact, India is a large country, which is densely populated, but the overall severity of COVID‐19 per million populations is lesser than any other country of the world. One of the major reasons for the aforesaid difference is the use of herbal remedies by the Government of India as a preventive measure for COVID‐19. Therefore, the present review focuses on the epidemiology and molecular pathogenesis of COVID‐19 and explores algal metabolites for their antiviral properties.

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Effect of different non-conventional extraction methods on the antibacterial and antiviral activity of fucoidans extracted from Nizamuddinia zanardinii

Cited by 123 publications

References 46 publications

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Potential of algal metabolites for the development of broad‐spectrum antiviral therapeutics: Possible implications in COVID‐19 therapy

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