Potential of algal metabolites for the development of broad‐spectrum antiviral therapeutics: Possible implications in <scp>COVID</scp>‐19 therapy

Sangtani, Rimjhim; Ghosh, Atreyee; Jha, Hem Chandra; Parmar, Hamendra Singh; Bala, Kiran

doi:10.1002/ptr.6948

Cited by 14 publications

(9 citation statements)

References 176 publications

(208 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional strain. Scytovirin on the other hand is known for hindering the aggression and proliferation of HIV and is being derived from the water extract of Scytonemavarium, a terrestrial cyanobacteria 204 .…”

Section: Alternative Of Corticosteroidsmentioning

confidence: 99%

Post COVID-19 complications, adjunct therapy explored, and steroidal after effects

Sonkar

Hase

Banerjee³

et al. 2022

Can. J. Chem.

View full text Add to dashboard Cite

For survivors of the COVID-19 disease, defeating the virus is just the beginning of a long road to recovery. The virus’s inducibility and catastrophic effects are distributed in multiple organs. The induction of cytokine storms in COVID-19 patients is due to the interaction of the SARS-CoV-2 virus and the host receptor, leading to various immunopathological consequences that might eventually lead to death. So far, it has hit tons of people across the world, but there is still no effective treatment. Patients facing the complications of COVID-19 after recovering have shown extensive clinical symptoms similar to previously circulating coronaviruses. Previous knowledge, and literature have opened up ways to treat this disease and manage post-COVID-19 complications, which poses a severe challenge to health system globally and may exacerbate the fragmentation of diseases. The use of steroids, as a treatment, showed various health problems and side-effects in COVID-19 patients. This review substantially discusses various post-COVID-19 complications observed, adjunctive therapies used along with common COVID-19treatment and spotlighted their side effects and consequences. This review provides latest literature on COVID-19 which emphasizes the subsequent complications in various organs, side-effects of drug, and alternative regimes that were used to treat COVID-19.

show abstract

Section: Alternative Of Corticosteroidsmentioning

confidence: 99%

Post COVID-19 complications, adjunct therapy explored, and steroidal after effects

Sonkar

Hase

Banerjee³

et al. 2022

Can. J. Chem.

View full text Add to dashboard Cite

show abstract

“…In this respect, algae bioactive compounds having antioxidant and antiviral activities could be explored as possible supportive therapy. Some of the recently tested algal compounds have been promising indications that they are both pharmacologically and commercially efficient antiviral agents and can be used worldwide on a commercial basis to eliminate the infectious pathogen responsible for the COVID-19 pandemic worldwide (71) .…”

Section: Algae Prospective During Covid-19 Pandemicmentioning

confidence: 99%

Algae Bioactive Constituents and Possible Role During COVID-19 Pandemic (A review)

Rashad

El-Chaghaby²

2021

IJPS

View full text Add to dashboard Cite

Nowadays, the use of natural bio-products in pharmaceuticals is gaining popularity as safe alternatives to chemicals and synthetic drugs. Algal products are offering a pure, healthy and sustainable choice for pharmaceutical applications. Algae are photosynthetic microorganisms that can survive in different environmental conditions. Algae have many outstanding properties that make them excellent candidate for use in therapeutics. Algae grow in fresh and marine waters and produce in their cells a wide range of biologically active chemical compounds. These bioactive compounds are offering a great source of highly economic bio-products. The present review discusses the phytochemical and bioactive compounds present in algae biomass and their potent biological activities. The review focuses on the use of alga in therapy and their pharmaceutical applications with special reference to the possible preventive and therapeutic role of algae against COVID-19.

show abstract

“…The mechanism of action anti-HIV-1 occurs when lectin or glycoproteins, bind to the carbohydrate moiety of the virus to inhibit its attachment to the target cells and also to hinder the replication of viral RNA (Sangtani et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Several bioactive metabolites derived from seaweeds including terpenes, lipids, proteins, polyphenols and especially a variety of algal polysaccharides have shown antiviral activity for the viral infections caused by HIV and others, such as HSV, human papillomavirus, dengue virus, as well as coronavirus (SARS-CoV2) (Wittine et al, 2019;Sangtani et al, 2020). All these compounds evidenced the inhibition of different stages of the virus life cycle.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Harb¹

View full text Add to dashboard Cite

A wide variety of metabolites extracted from macroalgae is currently used as functional food ingredients, natural nutraceuticals, biomedical materials, cosmetic formulations, as well as in other products that promote human health. One of the major limitations in the search for new extracts or natural products with biological action is the lack of available biomass for studies and even for their bioprospection. In this context, the availability of beach-cast marine algae is a sustainable and highly productive alternative. The main objective of this study was to evaluate the chemical and bioactive potential of extracts from 15 materials of beach-cast marine algae collected from the Brazilian coast to provide subsidies that allow identifying the potentialities and its uses as functional product. The findings showed that the highest antioxidant activities were found in extracts from brown beach-cast algae followed by the extracts of red beach-cast algae, and the lowest activities were detected in the green beach-cast species. The most efficient extracts of beach-cast species with antioxidant properties were from Dictyopteris jolyana, Zonaria tournefortii, and Osmundaria obtusiloba. Regarding antiviral activity, the aqueous extract of Codium isthmocladum and methanolic extracts from D. jolyana, Z. tournefortii Alsidium seaforthii, Spiridia clavata and O. obtusiloba were highly promising, reaching inhibition percentage above 90%. The extracts of Z. tournefortii, A, seaforthii and C. isthmocladum showed high cytotoxicity activity against the tumoral cells strains HL60 (leukemia) and HTC116 (colon) and did not show any cytotoxicity activity against non-tumoral human cells (HGF1). Currently, the large amount of beach-cast seaweeds deposited on the beaches of Brazil is collected and treated as trash, being incinerated or disposed in landfills by the government. Instead of using public resources and making efforts for the removal of this biomass, it is possible to propose different uses for the Brazilian beach-cast seaweeds and transform it into applications for several sectors. Due to the antioxidant, antiviral, nutritional, photoprotective and cytotoxic properties reported for macroalgae, such applied features bring environmental benefits by mitigating coastal pollution generating a usable resource, in addition to ensuring sustainable social and economic development. The review data shown in the literature of Brazilian beach-cast algae shows the relevance and innovation of this study. This is the first report evaluating chemical composition, antioxidant potential, antiviral activity, cytotoxicity potential and photoprotection of extracts from beach-cast algae from the Brazilian coast. The potential of beach-cast seaweeds provides raw-material for several applications, combined with the large amount available on the beaches of certain regions at the Brazilian coast can be better exploited. The present study significantly contributes to increasing knowledge of Brazilian beach-cast algae and their potential uses as well as t...

show abstract

Potential of algal metabolites for the development of broad‐spectrum antiviral therapeutics: Possible implications in COVID‐19 therapy

Cited by 14 publications

References 176 publications

Post COVID-19 complications, adjunct therapy explored, and steroidal after effects

Post COVID-19 complications, adjunct therapy explored, and steroidal after effects

Algae Bioactive Constituents and Possible Role During COVID-19 Pandemic (A review)

Caracterização química, potencial antioxidante e atividade biológica de macroalgas arribadas do litoral brasileiro

Contact Info

Product

Resources

About