Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus

Elsner, Viviane Rostirola; Lovatel, Gisele Agustini; Bertoldi, Karine; Vanzella, Cláudia; Santos, Fátima; Spindler, Christiano; Almeida, E.F. de; Nardin, Patrícia; Siqueira, Ionara Rodrigues

doi:10.1016/j.neuroscience.2011.06.066

Cited by 83 publications

(35 citation statements)

References 69 publications

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“…On the other hand, experimental and clinical studies already reported that the impact of external stimuli such as exercise on acetylation levels status could be dynamic and with short-lived and acute outcomes, without any delayed effect [4,47,48]. This response may be act as a protective mechanism to maintain the homeostasis of the transcriptional machinery.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is essential to elucidate the mechanisms involved during the aging process and investigate new approaches that can improve brain function. Recent evidences pointed out that both normal aging process and the physiopathology of neurodegenerative disease incidence and progression are linked to epigenetic pathways imbalance [4][5][6]. Epigenetic mechanisms modulate gene expression patterns without affecting the primary deoxyribonucleic acid (DNA) sequence in response to external factors and environmental cues such as diet and exercise [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Costa¹,

Dorneles²,

Silva³

et al. 2017

J Syst Integr Neurosci

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Objective: To verify the chronic consumption of grape juice effects on weight, body mass index (BMI), cognitive function and the peripheral levels of global histone H4 acetylation, BDNF and inflammatory markers in elderly women according to age. Methods: This is a quasi-experimental study. The blood samples were collected before and after 30 days of grape juice supplementation (400 ml/daily) in women aged > 70 and < 70 years old. Weight, BMI and cognitive function, were measured before and after supplementation. Results: Grape juice consumption promoted a reduction on weight and BMI. This consumption also contributed to improve a cognitive function. These effects were more pronounced in the >70 years group. A tendency towards increased BDNF levels was observed in the >70 years group after intervention. Inflammatory markers and global histone H4 levels did not change. Conclusion: The chronic grape juice consumption is an interesting choice to promote health benefits in elderly women, which seem to act in an age-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Costa¹,

Dorneles²,

Silva³

et al. 2017

J Syst Integr Neurosci

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show abstract

“…As an example, after 60 minutes of exercise, changes have been observed in histone modifications associated with chromatin remodeling and transcriptional activation in human skeletal muscle (McGee et al, 2009). In rats, a single session of treadmill exercise reduces HDAC activity, increases HAT activity and increases the HAT/HDAC balance in rat hippocampus, suggesting that part of the neuroprotective effects of exercise could be mediated by epigenetic mechanisms (Elsner et al, 2011).…”

Section: Physical Activitymentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

253

161

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Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

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“…Se sabe, por ejemplo, que el BDNF es crucial para los procesos de señaliza-ción por calcio en neuronas glutamatérgicas que posteriormente exhiben fenómenos de plasticidad (Cechetti et al, 2008;Farmer et al, 2004;van Praag, 2008;van Praag, Kempermann & Gage, 1999;Zheng et al, 2006). También se ha demostrado que el uso de antagonistas de BDNF o la alteración en su expresión disminuyen la supervivencia neuronal y el aprendizaje (Abel & Rissman, 2013;Berchtold et al, 2010;Bertoldi et al, 2012;Elsner et al, 2011;Elsner et al, 2013;Gomez-Pinilla, Zhuang, Feng, Ying & Fan, 2011;Kaliman et al, 2011;Kong et al, 2010;Zajac et al, 2010). De acuerdo a lo anterior, es claro que muchas de las modificaciones estructurales y funcionales ocasionadas por actividad física estarían mediadas por interacciones tanto a nivel celular como posiblemente genético.…”

Section: Enriquecimiento Ambiental Ejercicio Y Actividad Físicaunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus

Cited by 83 publications

References 69 publications

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

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