Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Abstract

Objective: To verify the chronic consumption of grape juice effects on weight, body mass index (BMI), cognitive function and the peripheral levels of global histone H4 acetylation, BDNF and inflammatory markers in elderly women according to age. Methods: This is a quasi-experimental study. The blood samples were collected before and after 30 days of grape juice supplementation (400 ml/daily) in women aged > 70 and < 70 years old. Weight, BMI and cognitive function, were measured before and after supplementation. Results: Grape juice consumption promoted a reduction on weight and BMI. This consumption also contributed to improve a cognitive function. These effects were more pronounced in the >70 years group. A tendency towards increased BDNF levels was observed in the >70 years group after intervention. Inflammatory markers and global histone H4 levels did not change. Conclusion: The chronic grape juice consumption is an interesting choice to promote health benefits in elderly women, which seem to act in an age-dependent manner.

Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

“…we observed that the consumption of grape juice reduced the protein oxidation damage (Carbonyl levels). Corroborating our findings, healthy older adults who received 400 mL/day of purple grape for thirty days presented significant reduction in the levels of oxidative damage to proteins [33], but with a significant increase at superoxide dismutase activity, different from our study. This divergence could be partially explained because in the research conducted by Da Costa (2015) the participants were submitted only to the consumption of grape juice without the practice of physical exercise [33].…”

“…During the intervention period, ACQ-EXE þ GJ also drunk the juice, consuming 400 ml/daily. This grape juice amount was in accordance to the literature [31,33]. It was recommended for ACQ-EXE group to avoid grape derivates, grape juice, and wine.…”

“…The aquatic exercise program occurred twice a week, lasting one hour each session, totalling 8 sessions during 30 days. According to the literature, grape juice consumption during 30 days is able to reduce oxidative stress parameters in peripheral blood in elderly ones [33]. During the intervention period, ACQ-EXE þ GJ also drunk the juice, consuming 400 ml/daily.…”

“…Experimental studies showed that grape and its derivates could be useful against oxidative damage in the brain due to the presence of phenolic compounds [20,21,29,30]. Also, our group showed that the grape juice could be an important choice to improve the antioxidant profile and memory/cognition evaluation in older women [31,32,33]. Preclinical findings have supported the potential of polyphenols in providing neuroprotection against oxidative stress-induced toxicity in PD [26,34].…”

Fractionation of Extracts from Black Chokeberry, Cranberry, and Pomegranate to Identify Compounds That Influence Lipid Metabolism

“…Several studies have shown that polyphenols, especially anthocyanins and copigments, have antioxidant, anti-inflammatory, anti-bacterial, and anti-viral properties and are discussed in the context of influencing glucose and lipid metabolism in vitro as well as in vivo [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”