Effect of dietary fish oil supplementation on the antigen-induced late-phase response in the skin

Thien, Francis; Atkinson, Beryl A.; Khan, Ashraf; Mencia‐Huerta, Jean‐Michel; Lee, Tak H.

doi:10.1016/0091-6749(92)90438-8

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…Unfortunately, clinical trials with diet supplementation have been disappointing both with allergen provocation and in clinical asthma. [61][62][63] However, Broughton et al 64 have recently shown that only those patients who have high urine secretions of LTE 4 responded favorably to omega-3 fatty PUFA dietary supplementation, whereas in those who were low excretors the asthma deteriorated or was unchanged rather than improved. Because urinary LTE 4 excretion is a measure of the activity of the 5-LO pathway, 39,43 it is possible that responders and nonresponders to this dietary intervention could be determined by prior genotyping.…”

Section: Gene By Environment Interactionsmentioning

confidence: 99%

Genetic and environmental interaction in allergy and asthma☆☆☆

Holgate

1999

Journal of Allergy and Clinical Immunology

159

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Asthma is an inflammatory disorder of the airways involving coordinate up-regulation of T(H)2-type cytokines encoded in a cluster on chromosome 5q(31-33) on T cells and inflammatory cells. There is also a requirement for local airway susceptibility factors that, together with T(H)2 polarization, results in hyperresponsiveness, variable airflow obstruction, and, over time, remodeling of the airway wall. Asthma has strong genetic and environmental components that interact both in the induction and subsequent expression of the disease phenotypes. Multiple genes are involved and probably interact. Whole genome screens are beginning to identify gene-rich regions of special relevance to asthma and atopy, although a novel disease-related gene has yet to be discovered from these. By contrast, there are a plethora of candidate genes whose function in relation to disease pathophysiologic mechanisms and response to treatment are known. Two examples are polymorphisms involving IL-4 receptors and the enzymes controlling cysteinyl leukotriene production. Abnormal signaling between the epithelium, which is in contact with the environment, and the underlying (myo)fibroblasts and dendritic cells indicating reactivation of the epithelial mesenchymal trophic unit, which is involved in fetal lung development and branching, provide a basis for asthma that encapsulates both T(H)2 polarization and airway wall remodeling.

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Section: Gene By Environment Interactionsmentioning

confidence: 99%

Genetic and environmental interaction in allergy and asthma☆☆☆

Holgate

1999

Journal of Allergy and Clinical Immunology

159

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“…It is proposed that the more ‘proinflammatory’ Western diets favour immunological reactivity and Th2 differentiation during the critical time of early development. While increased dietary n‐3 PUFA intake has been associated with lower prevalence of asthma and allergic inflammation [11, 12], the benefits of n‐3 PUFA in established allergic disease are less clear [13–17]. However, potential dietary effects are likely to be more significant before immune responses are fully established, and suggest a possible role of early n‐3 PUFA supplementation in allergic disease prevention.…”

Section: Introductionmentioning

confidence: 99%

Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

Dunstan

Mori

Barden

et al. 2003

Clin Experimental Allergy

179

158

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“…When the immune parameters representing clinical symptoms characteristic of atopic dermatitis, pollinosis and allergic rhinitis normalize, the patients recover from allergic diseases (67,75). Therefore, normalization of these immune parameters by foods is helpful in that allergic patients recover their health and persons with a predisposition to allergies may avoid falling ill. Parietaria extract (76,77), herbal extract (78) and lactic acid bacteria (67,79–89) have been found to suppress allergic diseases in human subjects as well as animal models.…”

Section: Regulation Of Immune Functions By Foodsmentioning

confidence: 99%

“…Based on findings reported to date, we conclude that the following immune parameters can be used to evaluate the effects of foods on the clinical symptoms of allergic patients: (i) parameters to directly assess clinical symptoms in allergic patients: skin test (75,82), skin-induced response (76), SCORAD score (74,78,90); (ii) parameters that vary in association with the clinical symptoms of allergic patients: TNF-α level (65,66,79,91), soluble CD4 level (67), soluble CD23 level or inducible surface CD23 level (68,78,92), soluble IL-2R level (67,68,93,94), soluble VCAM level (70,78), amount of granular protein in eosinophils (ECP, EPX) (67,86,95); (iii) parameters possibly involved in the clinical symptoms of allergic patients: IgG 4 level (75), IL-4/IFN-γ production (81,96), TGF-β level (67,97,98), eosinophil number (81,99) (Table 1). …”

Section: Regulation Of Immune Functions By Foodsmentioning

confidence: 99%

Modulation of Immune Functions by Foods

Kaminogawa

Nanno

2004

Evidence-Based Complementary and Alternative Medicine

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Evidence is rapidly accumulating as to the beneficial effects of foods. However, it is not always clear whether the information is based on data evaluated impartially in a scientific fashion. Human research into whether foods modulate immune functions in either intervention studies or randomized controlled trials can be classified into three categories according to the physical state of subjects enrolled for investigation: (i) studies examining the effect of foods in healthy individuals; (ii) studies analyzing the effect of foods on patients with hypersensitivity; and (iii) studies checking the effect of foods on immunocompromized subjects, including patients who had undergone surgical resection of cancer and newborns. The systematization of reported studies has made it reasonable to conclude that foods are able to modulate immune functions manifesting as either innate immunity (phagocytic activity, NK cell activity) or acquired immunity (T cell response, antibody production). Moreover, improvement of immune functions by foods can normalize the physical state of allergic patients or cancer patients, and may reduce the risk of diseases in healthy individuals. Therefore, it is valuable to assess the immune-modulating abilities of foods by measuring at least one parameter of either innate or acquired immunity.

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Effect of dietary fish oil supplementation on the antigen-induced late-phase response in the skin

Cited by 7 publications

References 30 publications

Genetic and environmental interaction in allergy and asthma☆☆☆

Genetic and environmental interaction in allergy and asthma☆☆☆

Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

Modulation of Immune Functions by Foods

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