Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

Dunstan, Janet; Mori, Trevor A.; Barden, Anne; Beilin, Lawrence J.; Taylor, Angie; Holt, Patrick G.; Prescott, Susan L.

doi:10.1046/j.1365-2222.2003.01590.x

Cited by 179 publications

(177 citation statements)

References 48 publications

(57 reference statements)

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…Dunstan et al (26) found a consistent trend for attenuated infant Th1 (IFN␥), Th2 (IL-5, IL-13) as well as IL-10 responses to allergens after -3 supplementation of 89 atopic mothers during pregnancy. However, the neonates, whose mothers received fish oil, had significantly lower levels of circulating IL-13 in cord blood compared with the control group, which may reflect a subtle cytokine-shift favoring Th1 immunity (27). On the other hand, we did not see any effect of maternal -3 LCPUFA supplementation on chemokines when analyzing all infants, although high EPA and DHA concentrations very early in life were associated with high levels of the Th1 chemokine CXCL11 in the infant.…”

Section: Discussionmentioning

confidence: 90%

Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ω-3 Fatty Acid Supplementation During Pregnancy and Lactation

et al. 2011

View full text Add to dashboard Cite

ABSTRACT:We investigated whether the previously reported preventive effect of maternal -3 fatty acid supplementation on IgEassociated allergic disease in infancy may be mediated by facilitating a balanced circulating Th2/Th1 chemokine profile in the infant. Vaccine-induced immune responses at 2 y of age were also evaluated. Pregnant women, at risk of having an allergic infant, were randomized to daily supplementation with 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo from the 25th gestational week through 3.5 mo of breastfeeding. Infant plasma was analyzed for chemokines (cord blood, 3, 12, 24 mo) and anti-tetanus and anti-diphtheria IgG (24 mo). High Th2-associated CCchemokine ligand 17 (CCL17) levels were associated with infant allergic disease (p Ͻ 0.05). In infants without, but not with, maternal history of allergy, the -3 supplementation was related to lower CCL17/CXC-chemokine ligand 11 (CXCL11) (Th2/Th1) ratios (p Ͻ 0.05). Furthermore, in nonallergic, but not in allergic infants, -3 supplementation was linked with higher Th1-associated CXCL11 levels (p Ͻ 0.05), as well as increased IgG titers to diphtheria (p ϭ 0.01) and tetanus (p ϭ 0.05) toxins. Thus, the prospect of balancing the infant immune system toward a less Th2-dominated response, by maternal -3 fatty acid supplementation, seems to be influenced by allergic status. (Pediatr Res 69: 259-264, 2011)

show abstract

Section: Discussionmentioning

confidence: 90%

Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ω-3 Fatty Acid Supplementation During Pregnancy and Lactation

et al. 2011

View full text Add to dashboard Cite

show abstract

“…These observations suggest that LC n-3 PUFA during pregnancy do have effects on neonatal immune function. Furthermore, infants in the fish oil group were consistently less likely to develop clinical features including food allergy, recurrent wheeze, persistent cough, diagnosed asthma, angioedema, or anaphylaxis, compared with the control group (Dunstan et al 2003b). Although there was no difference in the frequency of atopic dermatitis at 1 year of age, infants in the fish oil group had significantly less severe disease (P ¼ 0·045), and were three times less likely to have a positive skin prick test to egg allergen at 1 year of age (P ¼ 0·055).…”

Section: Modulating Immune and Inflammatory Activity With Dietary N-3mentioning

confidence: 93%

The impact of long-chainn-3 polyunsaturated fatty acids on human health

et al. 2005

View full text Add to dashboard Cite

A considerable literature has been published on the health benefits of fish, oil-rich fish and fish oils and their constituent long-chain (LC)n-3 PUFA. Evidence from epidemiological studies highlights the cardioprotective attributes of diets rich in fish, especially oil-rich fish. Data from intervention trials are consistent in suggesting that LCn-3 PUFA lower the risk of CVD, probably by the multiple mechanisms of lowering serum triacylglycerols, improving the LDL:HDL ratio, anti-arrhythmic effects on heart muscle, improved plaque stability, anti-thrombotic effects and reduced endothelial activation. Research indicates LCn-3 PUFA provision has an impact during development, and there is preliminary evidence that docosahexaenoic acid supplementation during pregnancy could optimise brain and retina development in the infant. LCn-3 PUFA are also postulated to ameliorate behavioural and mental health disturbances such as depression, schizophrenia, dementia and attention deficit hyperactivity disorder. However, despite some positive evidence in each of these areas, use of LCn-3 PUFA in these conditions remains at the experimental stage. In the case of immune function, there is little doubt that LCn-3 PUFA have a positive effect. Although intervention trials in rheumatoid arthritis show strong evidence of benefit, evidence for efficacy in other inflammatory conditions, including Crohn's disease, ulcerative colitis, psoriasis, lupus, multiple sclerosis, cystic fibrosis and asthma, is inconsistent or inadequate. More promising evidence in some conditions may come from studies which attempt to modify the fetal environment using LCn-3 PUFA supplementation during pregnancy.

show abstract

“…Epidemiological studies conducted in children revealed an inverse association between high fish consumption, which provides long chain omega-3 fatty acids, and the prevalence of asthma and bronchial hyperresponsiveness, and inferred that a decreased omega-6 to omega-3 ratio attenuates the inflammatory immune reaction [8][9][10][11]. Evidence from a recent clinical study in neonates indicates that altered membrane PUFA profiles during gestation may influence immunological function [12].…”

mentioning

confidence: 99%

Food and fatty acid intake and atopic disease in adults

Trak-Fellermeier¹,

Brasche²,

Winkler³

et al. 2004

European Respiratory Journal

View full text Add to dashboard Cite

The aim of the study was to assess the relationship between dietary intake of selected foods and fatty acids with atopic disease prevalence in adults.Data from the European Community Respiratory Health Survey in Erfurt, combined with a 3-day weighed records dietary survey, was used. Complete data was available from 469 males and 333 females aged 20-64 yrs. Multiple logistic regression was applied comparing the highest with the lowest quartile of dietary exposures and linear trends were tested stratified by sex.In males, margarine intake and a high ratio of omega-6 to omega-3 fatty acids were positively associated with hay fever. In females, a high intake of total fat, palmitoleic and oleic acids were positively associated with sensitisation. A high total fat, high monounsaturated fatty acid and high oleic acid consumption were positively associated with hay fever.Whilst an excessive intake of fat or imbalance in fat intake, particular of monounsaturated fatty acids, increased the risk for hay fever and allergic sensitisation in females, mostly no significant associations were found for males. Dietary factors were mostly not related with prevalence rates of bronchial hyperresponsiveness and atopic eczema either in males or in females.

show abstract

Maternal fish oil supplementation in pregnancy reduces interleukin‐13 levels in cord blood of infants at high risk of atopy

Cited by 179 publications

References 48 publications

Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ω-3 Fatty Acid Supplementation During Pregnancy and Lactation

Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ω-3 Fatty Acid Supplementation During Pregnancy and Lactation

The impact of long-chainn-3 polyunsaturated fatty acids on human health

Food and fatty acid intake and atopic disease in adults

Contact Info

Product

Resources

About