Effect of Dietary Cabbage Fermentation Extract and Young Barley Leaf Powder on Immune Function of Sprague-Dawley Rats.

Miyazaki, Y.; Tokunaga, Yoshiharu; Takagaki, Kinya; Tsusaki, Sinji; Tachibana, Hirofumi; Yamada, Koji

doi:10.3177/jnsv.47.253

Cited by 6 publications

(6 citation statements)

References 23 publications

(8 reference statements)

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“…In biological studies, products made by fermentation have been shown to exhibit immunomodulatory effects. For example, rats fed with diets supplemented with fermentation extract of cabbage showed better immune function than controls 8 . LeBlanc et al 9 .…”

Section: Discussionmentioning

confidence: 99%

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Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus

Ashida

Okimasu

2005

Fisheries Sci

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The stimulatory effect of fermented vegetable product (FVP) upon the phagocytic and superoxide generation of leukocytes was studied in the Japanese flounder Paralichthys olivaceus . The phagocytic activity of casein-induced, intraperitoneal leukocytes was investigated and quantified, that is the activity significantly increased ( P < 0.05 or < 0.01) by the addition of FVP beyond 3 mg/kg body weight. Further analysis investigated the effect of FVP on superoxide generation in leukocytes. Established in vitro cytochrome c reduction assay was used to measure superoxide generation; reduced levels of FVP in assay samples had a profound effect on superoxide generation. FVP was also incorporated in commercial diets and fed to Japanese flounder for 4 weeks. The phagocytic activities and superoxide generation of peritoneal induced leukocytes were significantly higher ( P < 0.05, < 0.01) in fish fed the FVP supplemented diet than fish fed the control diet. FVP feeding in fish had a significantly higher ( P < 0.05) activity of lysozyme than in the control fish.KEY WORDS: fermented vegetable product, immunostimulation, Japanese flounder, nonspecific immunity.

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Section: Discussionmentioning

confidence: 99%

“…For example, rats fed with diets supplemented with fermentation extract of cabbage showed better immune function than controls. 8 LeBlanc et al . 9 reported that the peptidic fractions from fermented milk play important roles in the modulation of the cellular immune response.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus

Ashida

Okimasu

2005

Fisheries Sci

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“…For example, a cabbage fermentation extract and young barley leaf powder were seen to reinforce Ig productivity in both systemic and intestinal immune systems (Miyazaki et al, 2001). Koh et al (2002) reported the immunomodulating capacity of a water-extract of rice bran previously fermented by Saccharomyces cerevisiae.…”

Section: Introductionmentioning

confidence: 98%

Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation

Duarte

Vinderola

Ritz³

et al. 2006

Immunobiology

118

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“…Its biological effects have also been addressed by various in vitro and in vivo studies, although evidence there is limited evidence of the efficacy of Bex against specific conditions (22). The effect of Bex on the immune system was revealed in in vitro and in vivo experimental sets (23)(24)(25). Accordingly, Bex inhibited atopic dermatitis in NC/Nga mice by altering the expression levels of cytokines (26).…”

Section: Introductionmentioning

confidence: 99%

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

Woo

Kwon

et al. 2017

Biomedical Reports

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Abstract. Cancer remains a leading cause of mortality worldwide, therefore food products are being investigated for potential prevention or treatment strategies. The ingredient, barley grass extract (Hordeum vulgare L.; Bex) is used to prevent or ameliorate various types of disease. In cancer, Bex has been revealed to inhibit tumor growth. However, its effect on cancer cells is yet to be clearly defined. In the present study, the effect of Bex on cancer cell growth was investigated. Bex inhibited the viabilities of breast and prostate cancer cells according to the results of MTT assays. Accordingly, Bex caused apoptosis, which was confirmed by Annexin V staining and western blot analysis for poly (ADP-ribose) polymerase and caspases. Furthermore, Bex increased the intracellular levels of reactive oxygen species (ROS), and N-acetyl-L-cystein blocked Bex-induced apoptosis. Therefore, the study demonstrated that Bex causes apoptosis of breast and prostate cancer cells by increasing intracellular ROS levels. IntroductionCancer is one of the leading causes of mortality worldwide (1,2). Despite numerous cancer studies and the development of various anti-cancer therapeutic agents, cancer remains dangerous. Anti-cancer therapeutic agents are chemically or biologically produced, and their effects are well defined (3-7). However, treatments continue to be associated with adverse effects and the majority of patients have an aversion to them (8).Herbal products have long been used to prevent or treat diseases, including cancer (9-12). Furthermore, certain anti-cancer therapeutic agents that are chemically produced originate from herbal products and their chemical characteristics are modified (7,(12)(13)(14). Typically, patients prefer to take herbal products (15-18); herbal products have historically been used as traditional medicines, such as traditional Chinese and Korean medicines, Kampo medicines and Ayurvedic medicine (13,14,19). Certain herbal products were demonstrated to treat cancer and/or reduce the side effects of cancer treatment (13,(15)(16)(17)(19)(20)(21). Therefore, herbal products are considered to be promising for cancer prevention and treatment.Barley grass extract (Hordeum vulgare L.; Bex) has long been used as a food product. Its biological effects have also been addressed by various in vitro and in vivo studies, although evidence there is limited evidence of the efficacy of Bex against specific conditions (22). The effect of Bex on the immune system was revealed in in vitro and in vivo experimental sets (23-25). Accordingly, Bex inhibited atopic dermatitis in NC/Nga mice by altering the expression levels of cytokines (26). Similarly, Bex repressed lipopolysaccharide-induced inflammation (27). Furthermore, its effect in type 2 diabetes was revealed in a genetically engineered mouse model and patients (28,29). Therefore, the effects of Bex on particular diseases have been demonstrated at least in experimental systems. A previous study revealed that Bex caused apoptosis of leukemia and lymphoma cell lines...

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Effect of Dietary Cabbage Fermentation Extract and Young Barley Leaf Powder on Immune Function of Sprague-Dawley Rats.

Cited by 6 publications

References 23 publications

Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus

Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus

Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

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