Effect of Dichloromethylene Diphosphonate on Fluoride Balance in Healthy Men

Maheshwari, Uma; Leybin, L; McDonald, Janet; Schneider, Victor; Newbrun, Ernest; Hodge, Harold C.

doi:10.1177/00220345830620051001

Cited by 3 publications

(2 citation statements)

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“…There have been suggestions to combine clodronate and fluoride in preventing the loss of bone mass (Grynpas & Cheng 1988;Hyvonen & Hanhijarvi 1989;Maheswari et al 1983). In the light of our previous work (Hyvonen et al 1986), this approach seems plausible, since there was no excess accumulation of fluoride in bone of animals receiving clodronate when the drug was given at the same time as fluoride.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Dichloromethylene Bisphosphonate on the Healing of a Long Bone Fracture, Composition of Bone Mineral and Histology of Bone in the Rat

Hyvönen

Karhi²,

Kosma³

et al. 1994

Pharmacology & Toxicology

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The effects of dichloromethylene bisphosphonate (clodronate) on the composition of bone mineral, morphology and histology of a long bone with an artificial femoral fracture were studied in a 22 week experiment. Two hundred twenty-four female rats were allocated to dose groups of 0, 3, 10, and 30 mg/kg clodronate daily subcutaneously. Bone calcium, phosphorus and magnesium concentrations remained stable and fluoride concentration rose with time. There were no statistical differences between different groups. Clodronate did not alter the histology of the callus nor delayed the healing of the fracture. It caused mild to moderate prominence of the metaphyseal area in the fractured bone in a dose- and time-dependent manner. Serum osteocalcin levels were lowered in the treated animals dose-dependently. Other serological as well as haematological values were within normal range. Clodronate seems in this experimental arrangement to be a safe agent to administer in different pathological conditions of bone even when they are complicated by fractures of long bones.

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Section: Discussionmentioning

confidence: 99%

The Influence of Dichloromethylene Bisphosphonate on the Healing of a Long Bone Fracture, Composition of Bone Mineral and Histology of Bone in the Rat

Hyvönen

Karhi²,

Kosma³

et al. 1994

Pharmacology & Toxicology

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“…Vários modelos de estudos de interesse odontológico foram realizados utilizando os bisfosfonatos focalizando o desenvolvimento dentário, observando a influência destas drogas, na liberação de flúor 90 , na erupção dentária 54 , no esmalte, na dentina e na cárie dentária 9,16,34,46,47,48,79,101,133,146,164,165 ; na cirurgias e na doença periodontal 13,19,71,72,83,115,138,166,176 , nos traumatismos e em procedimentos cirúrgicos em geral 6,71,72,117 ; comprovando também o efeito antimicrobiano dos bisfosfonatos 55,88,172 que estabeleceu conexão com as camadas de análogos de dentina nas raízes.…”

Section: Efeitos Dos Bisfosfonatos Nos Tecidos Dentários E Circunjaceunclassified

"Influência dos bisfosfonatos na movimentação dentária induzida, na freqüência e nas dimensões das reabsorções radiculares associadas"

Ortiz¹

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Nutrition and Bone Health in Space

Smith

Heer

Zwart

2014

Nutrition and Bone Health

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The effect of weightlessness on the human skeletal system is one of the greatest concerns in safely extending space missions [ 1 -11 ]. The ability to understand and counteract weightlessness-induced bone mineral loss will be vital to crew health and safety during and after extended-duration space station and exploration missions [ 1 -7 ]. Research on bone mineral loss during space fl ight has gone on for more than half a century, and recent studies have shown signifi cant progress in developing countermeasures that have proved to be effective, including good nutrition and exercise. We review the history of this research here and provide a summary of recent and ongoing studies, including efforts to counteract bone and calcium loss resulting from weightlessness. Key Points• The effect of weightlessness on the human skeletal system is one of the greatest concerns in safely extending space missions.• The ability to understand and counteract weightlessness-induced bone mineral loss will be vital to crew health and safety during and after extended-duration space station and exploration missions.• Research on bone mineral loss during space fl ight has gone on for more than half a century, and recent studies have shown signifi cant progress in developing countermeasures that have proved to be effective, including good nutrition and exercise.

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Effect of Dichloromethylene Diphosphonate on Fluoride Balance in Healthy Men

Cited by 3 publications

References 14 publications

The Influence of Dichloromethylene Bisphosphonate on the Healing of a Long Bone Fracture, Composition of Bone Mineral and Histology of Bone in the Rat

The Influence of Dichloromethylene Bisphosphonate on the Healing of a Long Bone Fracture, Composition of Bone Mineral and Histology of Bone in the Rat

"Influência dos bisfosfonatos na movimentação dentária induzida, na freqüência e nas dimensões das reabsorções radiculares associadas"

Nutrition and Bone Health in Space

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