Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats

Abstract

This study focuses on the effect of ‘Diashis’, a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with ‘Diashis’ in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by ‘Diashis’ which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. ‘Diashis’ was not found to have any metabolic toxicity. The antidiabetic effects of ‘Diashis’ were compared with those of the antidiabetic drug, ‘Glibenclamide’.

RETRACTED ARTICLE: Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation “Qurs Tabasheer” in streptozotocin induced diabetic rats

“…Many polyherbal formulation such as Okudiabet [5] Diashis [6], Diasulin [7] etc. have revealed their efficacy and potency against diabetes.…”

Biological Effect of Sucralose in Diabetic Rats

“…In the current study, diabetic rats showed a significant increase of glucose associated to a significant decrease of insulin, level, compared to their respective values in the control group. This could be explained by the fact that STZ induces degeneration in Langerhans islet beta cells [33][34][35]. The administration of sucralose to diabetic rats has no effect on insulin while reduces glucose level, compared to diabetic rats receiving distilled water.…”

Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats

“…Such effect may be explained in part by either a decrease in the rate of intestinal glucose absorption [23-25] or an increase in peripheral glucose utilization [24,25]. In this line, some authors have ascertained increased catabolism of glucose due to GLUT4 translocation to the plasma membrane in muscle and brown adipose cells [19,20], with up-regulation of the uncoupling protein-1 in brown adipose tissue and hepatic gluconeogenesis [25,26], causing as a result hyperinsulinemia or enhancement of peripheral glucose utilization [19,27,28]. Moreover, a possible stimulatory mechanism on the few surviving β-cells has been considered, which could allow the release of more insulin [29-32].…”