Biological Effect of Sucralose in Diabetic Rats

Saada, Helen N.; Mekky, Nefissa H.; Eldawy, Hassan A.; Abdelaal, Abeer F.

doi:10.4236/fns.2013.47a010

Cited by 10 publications

(11 citation statements)

References 52 publications

(48 reference statements)

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“…These hormones are peptides secreted by the enteroendocrine cells of the small intestine [ 42 ], are released in response to food intake, and have an important effect on the control of satiety and homeostasis of plasma glucose. In this work, Glucose Insulinotropic Peptide (GIP) was quantified for its metabolic function [ 43 , 44 ]. The results showed that sucralose reduces the secretion of GIP, glycaemia, and the HOMA index, but did not modify the insulin concentration; it also caused an increase in body weight with a reduction in feed intake, probably due to an increase in leptin secretion.…”

Section: Discussionmentioning

confidence: 99%

Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

Rosales-Gómez

Martínez-Carrillo

Reséndiz-Albor

et al. 2018

BioMed Research International

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Background The consumption of sweeteners has increased in recent years, being used to control body weight and blood glucose. However, they can cause increased appetite, modification of immune function, and secretion of hormones in the GALT. Objective To assess the effect of chronic sweetener consumption on glycaemia, cytokines, hormones, and GALT lymphocytes in CD1 mice. Material and Methods 72 CD1 mice divided into 3 groups were used: (a) baseline, (b) middle, and (c) final. Groups (b) and (c) were divided into 4 subgroups: (i) Control, (ii) Sucrose, (iii) Sucralose, and (iv) Stevia. The following were determined: body weight, hormones (GIP, insulin, and leptin), lymphocytes CD3+T cells and CD19+B cells, IgA+ plasma cells, and cytokines (IL-4, IL-5, IFN-γ, and TNF-α). Results Sucralose reduces secretion of GIP and glycaemia but does not modify insulin concentration, increases body weight, and reduces food intake. Stevia increases the secretion of GIP, insulin, leptin, body weight, and glycaemia but keeps food consumption normal. Sucralose and Stevia showed a higher percentage of CD3+T cells, CD19+B cells, and IgA+ plasma cells in Peyer's patches, but only Stevia in lamina propria. Conclusion Sweeteners modulate the hormonal response of cytokines and the proliferation of lymphocytes in the intestinal mucosa.

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Section: Discussionmentioning

confidence: 99%

Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

Rosales-Gómez

Martínez-Carrillo

Reséndiz-Albor

et al. 2018

BioMed Research International

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“…Thus, it is still unclear whether the consumption of NNS is helpful in the management of obesity and diabetes and related diseases. Some studies in healthy individuals and individuals with type 2 diabetes have demonstrated that sucralose does not affect appetite, glucose homeostasis, glucagon-like peptide-1 (GLP-1), and serum insulin (Brown, Brown, Onken, & Beitz, 2011;Ford et al, 2011;Grotz et al, 2003), while a review report and a study in diabetic rat suggest that sucralose consumption alters serum glucose, insulin, GLP-1 and lipid profile (Saada, Mekky, Eldawy, & Abdelaal, 2013;Schiffman & Rother, 2013). Studies conducted in mice suggested that NNS, including saccharine, aspartame, and sucralose induced glucose intolerance by altering gut microbiota (Suez et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of commonly used commercially available non‐nutritive sweeteners on diabetes‐related parameters in non‐diabetic rats

et al. 2020

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Studies of non-nutritive sweeteners (NNS) in diabetes models have been limited to their pure forms or NNS-sweetened products. Hence, we conducted a comparative study on the effects of commercial table-top NNS on diabetes-related parameters in non-diabetic rats. Normal animals were fed for 5 weeks with aqueous solutions of aspartame-, sucralose-, stevia-, sodium cyclamate-and saccharin-based commercial NNS at concentrations equivalent to the sweetness of 10% sucrose solution and thereafter food intake, blood glucose, lipid profile, and biochemical parameters were measured. Aspartame adversely affected blood cholesterols, while cyclamate increased food intake and weight gain. Stevia reduced weight gain and exhibited insulinotropic effects. These data in normal rats hypothetically suggest that stevia-based NNS may help in glycemic control and body weight management, while cyclamateand aspartame-based NNS may increase body weight and risk of cardiovascular diseases. Further clinical studies are, however, required to confirm the results of this study. Practical applications The use of NNS is becoming more popular, especially for individuals with diabetes. However, while there are several commercial table-top NNS available in the market, little is known about how they affect most diabetes-related parameters of consumers, as most of the previous studies on NNS have been limited to their pure forms or NNS-sweetened products. Therefore, we comparatively studied the effects of some commercially available table-top forms of the different NNS (aspartame, sucralose, cyclamate, saccharin, and stevia) on diabetes-related parameters in normal rats. These findings in normal rats suggested that some commercially available NNSs like stevia-based NNS may be suitable for glycemic control and body weight management, while cyclamate-and aspartame-based NNS may increase body weight and risk of cardiovascular diseases. However, these finding in normal rats is subject to additional corroborative clinical studies. How to cite this article: Mbambo NP, Dlamini SN, Chukwuma CI, Islam MS. Comparative effects of commonly used commercially available non-nutritive sweeteners on diabetes-related parameters in normal rats.

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“…Although several clinical studies have consistently suggested that both acute and chronic consumption of SU has no effects on insulin, GLP-1, glucagon, and glucose homeostasis, recent animal studies have reported contradictory results [ 26 , 27 , 28 ]. Saada et al [ 29 ] recently investigated the effects of SU administration in normal and STZ-diabetic rats at a daily dose of 11 mg kg −1 BW for six weeks. Their results indicated that SU administration reduces serum glucose and has no effects on serum insulin concentrations [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Saada et al [ 29 ] recently investigated the effects of SU administration in normal and STZ-diabetic rats at a daily dose of 11 mg kg −1 BW for six weeks. Their results indicated that SU administration reduces serum glucose and has no effects on serum insulin concentrations [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats

et al. 2023

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Numerous food organizations have identified excessive calorie consumption and accompanying ailments as significant health risks associated with high sugar consumption. Administering stevioside (ST), sucralose (SU), and the two synergically (SU+ST) affected normal rats’ weight gain. In the current study, SU showed the highest undesired effect. Indeed, administering the three treatments to diabetic rats (DR) did not improve the rats’ weight gain. Although, insulin injection synergically with the treatments improved the weight gain, as recorded after three weeks. The best-improving rate was observed in the ST group. After the administration of ST and ST+SU to the DR, the blood glucose level (GL) was positively affected, with SU having no effects on reducing the GL. A considerable reduction in serum insulin (SIL) was noted in the DR+SU group. On the contrary, ST did not negatively affect the SIL, rather an improvement was recorded. In addition, giving SU did not significantly affect the ALT level in the DR or normal rats (NR). A significant improvement in total bilirubin (TBILI) was observed when insulin was injected with ST or SU in DR groups. Further, triglycerides (TG) after administering ST, SU, or ST+SU to NR had no significant difference compared to the control group (NR). Although, the three treatments markedly but not significantly lowered TG in the DR. For total cholesterol (CHO), both DR and NR had no significant effect after the three treatments. No histopathological alterations were recorded in the NR group. Diffuse and severe atrophy of the islands of Langerhans due to depletion of their cells and mild papillary hyperplasia of the pancreatic ducts were represented by a slightly folded ductal basement membrane and newly formed ductules in STZ-DR. Simultaneous atrophy and absence of the cells of islands of Langerhans besides ductal hyperplasia were evident in DR+SU. Hyperplastic ductal epithelium and atrophic Langerhans cells were seen in DR+SU+In. Degeneration and mild atrophy were observed in the islands of Langerhans structures. There was essentially no noticeable change after utilizing ST. A slight shrinkage of the Langerhans’ islets was detected in DR+ST. In DR+ST+In, no histopathological alterations in the islands of Langerhans were recorded. Congestion in the stromal blood vessels associated with degenerative and necrotic changes in the cells of the islands of Langerhans in DR+SU+ST was observed. In NR+SU, congestion of the blood vessels associated with mild atrophy in the islands of Langerhans and dilatation in stromal blood vessels was noticed. In conclusion, ST is safe, and SU should be taken cautiously, such as mixing with ST and/or taken at a very low concentration to avoid its drastic effect on the human body.

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Biological Effect of Sucralose in Diabetic Rats

Cited by 10 publications

References 52 publications

Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

Comparative effects of commonly used commercially available non‐nutritive sweeteners on diabetes‐related parameters in non‐diabetic rats

Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats

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