Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation

Mowafi, Hany A.; Aldossary, N.; Ismail, Salah A.; Alqahtani, Jaber S

doi:10.1093/bja/aen020

Cited by 54 publications

(65 citation statements)

References 24 publications

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“…before induction as a premedicant blunted the rise in IOP caused by suxamethonium, laryngoscopy and endotracheal intubation. Our study correlates with the studies done by G Weigert (2007) 12 , Mowafi (2008) 7 and Pal CK (2011) 8 , as in all of their studies there is a reduction in IOP in dexmedetomidine and clonidine Groups at various time intervals.…”

Section: Discussionsupporting

confidence: 92%

“…It has been observed that the rise of IOP with suxamethonium and intubation can be blunted with dexmedetomidine premedication. 7 In the year 2014, Shalini et al 8 concluded that dexmedetomidine premedication obtund the intraocular pressure rise after suxamethonium and endotracheal intubation. Aim of this study is to compare the effect of IV dexmedetomidine and IV clonidine premedication on the intraocular pressure changes haemodynamic responses after succinylcholine injection and intubation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

Yadav¹,

Pareek²,

Sharma³

2016

jemds

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

Yadav¹,

Pareek²,

Sharma³

2016

jemds

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“…Hence in our study we administered the bolus dose over 10 minutes. 15 The administration of the test drugs over 10 minutes in our study concurs with the studies conducted by Mowafi et al 10 Basar et al 12 and Kunisawa et al 4 …”

Section: Methods Of Administrationsupporting

confidence: 92%

“…The decrease in mean MAP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was statistically highly significant compared to same in group CT(p=0.000). DISCUSSION: Dexmedetomidine has been found by various authors [1][2][3][4][5][10][11][12][13] to blunt the haemodynamic response for laryngoscopy and intubation. Different doses of Dexmedetomidine have been used to find the effectiveness for blunting haemodynamic responses to laryngoscopy and intubation, with conflicting results.…”

Section: Repeated Measure Anovamentioning

confidence: 99%

A Clinical Study of Effect of Two Different Doses of Dexmed E Tomidine on Haemodynamic Response to Laryngoscopy and Endotracheal Intubation

D¹,

Tegginamath²,

Y³

2015

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OBJECTIVE OF THE STUDY:To compare the effectiveness of two different doses of Dexmedetomidine, 0.6μg/kg body weight and 1μg/kg body weight in attenuating haemodynamic response to laryngoscopy and endotracheal intubation. MATERIAL AND METHODS: 90 ASA Class 1 patients posted for elective surgery divided into 3 groups, Group DX-0.6 receive Dexmedetomidine, 0.6μg/kg body weight Group DX-1 receive Dexmedetomidine, 1μg/kg body weight and Group CT receive normal saline. The HR, SBP, DBP, MAP recorded at different intervals. OBSERVATIONS: There was a decrease in mean HR in group DX-0.6 and group DX-1 (p=0.000) when compared to group CT at 1 st , 5 th and 10 th minutes after intubation and showed a fall in SBP in group DX-0.6 and group DX-1 at 2 nd min, 5 th min and 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean SBP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared group CT (p=0.000). Significant fall in DBP in group DX-0.6 and group DX-1 at 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean DBP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT (p=0.000). A fall in MAP in group DX-0.6 and group DX-1 at 2 nd min, 5 th min and 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean MAP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT(p=0.000). CONCLUSION: Dexmedetomidine -0.6µg/kg body weight and 1µg/kg body weight are equally efficacious in obtunding the haemodynamic responses to laryngoscopy and endotracheal intubation. KEYWORDS: Different doses of dexmeditomedine, laryngoscopy, intubation. BACKGROUND:Dexmedetomidine in the dose of 0.6µg/kg body weight 1-3 and 1µg/kg body weight 4-7 as intravenous bolus for attenuating the haemodynamic response. There are conflicting reports as to which dose of the drug is idealy to suppress the intubation response and also have minimal adverse effects. So, the present study is aimed at comparing the effectiveness of two different doses of intravenous Dexmedetomidine, 0.6µg/kg body weight and 1µg/kg body weight for attenuating haemodynamic response to laryngoscopy and endotracheal intubation.

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“…9,10 In 1989 Indu et al, suggested that sublingual nifedipine is effective in attenuating the IOP response after succinylcholine administration, laryngoscopy and intubation. 11 In 1993 Kelly et al, studied the effect of succinylcholine in 15 patients undergoing elective enucleation, after all the extraocular muscles were detached in the diseased eye to that of the normal eye that had the extraocular muscles attached. Baseline IOP was comparable in both eyes.…”

Section: Discussionmentioning

confidence: 99%

A comparative evaluation of intravenous dexmedetomidine and oral clonidine in attenuating the rise in intra ocular pressure

Yadhuraj

Somasekharam

Vinay

et al. 2017

Int J Basic Clin Pharmacol

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Background: Administration of Suxamethonium, laryngoscopy and intubation is associated with rise in intraocular pressure (IOP). The need to attenuate rise in IOP is of utmost importance, especially in patients with perforating injury of the eyeball. The present study was undertaken to compare the effectiveness of intravenous Dexmedetomidine 0.4μg/kg and oral Clonidine 3μg/kg in attenuating the rise in IOP following administration of suxamethonium, laryngoscopy and intubation.Methods: 150 patients of ASA I or II, aged between 18-60 years, who were posted for elective non-ophthalmic surgery requiring general anaesthesia were included in this study. Patients were randomly divided into 3 groups with 50 patients in each group. Group-D: Received 0.4μg/kg IV dexmed in 10ml sterile water, over 10 min before induction. Group-C: Received 3μg/kg oral clonidine two hours prior to surgery. Group-S: Control group.Results: IOP, MAP, and HR were recorded at baseline, before induction, after induction, 1 min, 3 min and 5 min after administration of suxamethonium. Although Suxamethonium laryngoscopy and intubation increased IOP in all the 3 groups there was significant reduced rise in IOP noted in dexmed group and clonidine group compared to study group (p= <0.001). Furthermore, patients in dexmed group had lesser rise in IOP compared to clonidine group (p= <0.001).Conclusions: We concluded that both intravenous dexmedetomidine 0.4μg/kg and oral clonidine 3μg/kg, significantly attenuated the rise in IOP associated with administration of suxamethonium, laryngoscopy and intubation. However intravenous dexmedetomidine proved better than oral clonidine in attenuating the rise in IOP.

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Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation

Abstract: We conclude that dexmedetomidine could be a beneficial premedication in open globe injuries.

Cited by 54 publications

References 24 publications

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

A Clinical Study of Effect of Two Different Doses of Dexmed E Tomidine on Haemodynamic Response to Laryngoscopy and Endotracheal Intubation

A comparative evaluation of intravenous dexmedetomidine and oral clonidine in attenuating the rise in intra ocular pressure

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