A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

Yadav, Preeti; Pareek, Anita; Sharma, Aditi

doi:10.14260/jemds/2016/427

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…dexmedetomidine or saline, and their IOP was measured before, during, and after succinylcholine administration and intubation (Ahmad et al, 2016;ref). 14 In a 2016 study by Yadav et al, 15 Group 1 received 1 mcg/kg of dexmedetomidine in 100 mL of normal saline, Group 2 received 1 mcg/kg of clonidine in 100 mL of normal saline, and Group 3 received 100 mL of saline administered intravenously over 10 min as a placebo.…”

Section: Dose Of Dexmedetomidine Employed and Administeredmentioning

confidence: 99%

To study dexmedetomidine’s effect on intraocular pressure after succinylcholine and endotracheal intubation

Surya Gowthami Katika,

Sri Harsha Merugu,

Jaya Chandra Tentu

et al. 2023

Asian J Med Sci

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Background: One of the most important preconditions for any anesthetic operation is perioperative hemodynamic stability during laryngoscopy and intubation, which has been the subject of extensive research and documentation. Numerous approaches have been proposed to protect the patient from the sympathetic reaction, intraocular pressure (IOP) response, and catecholamine response during laryngoscopy and intubation. Aims and Objectives: To study the efficacy of two doses of intravenous dexmedetomidine premedication given as a single bolus dose over 10 min, 0.4 μg/kg and 0.6 μg/kg, 10 min before induction in preventing the rise of intraocular pressure following succinylcholine administration and endotracheal intubation. Materials and Methods: A retrospective randomized study was conducted. Ethical committee permission and signed informed consent were obtained from 60 eligible patients before the trial began. Results: Premedication with either 0.4 mcg/kg I.V. or 0.6 mcg/kg I.V. of dexmedetomidine diluted in normal saline at a 2 mcg/mL concentration administered over 10 min before induction resulted in significant obtundation of the rise in IOP associated with succinylcholine administration and intubation. Sympathetic response to laryngoscopy and intubation was also significantly diminished. The dose of 0.4 mcg/kg I.V. produced the best hemodynamic stability. Conclusion: Therefore, from the above research it can be concluded that, before succinylcholine delivery and intubation, dexmedetomidine 0.4 mcg/kg I.V. can be used as a premedication in situations where an increase in IOP could be hazardous.

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Section: Dose Of Dexmedetomidine Employed and Administeredmentioning

confidence: 99%