Effect of Desferrioxamine on Trace Metals in Rat Organs

Effects of desferrioxamine and iron on hematologic values, urinary iron, and antiferritin antibody production in the pig

“…Further examination of this table shows that the greatest excretion of iron occurs during the eight-hour period following desferrioxamine injection. This confirms the work of Yunice et al (1968) and Walsh et al (1965) who worked with other species. Very little increased iron excretion is seen due to desferrioxamine during the eighth to 16th hour period after injection, and the iron excretion is essentially at normal levels from the 16th through the 24th hour after injection.…”

Effects of desferrioxamine and iron on hematologic values, urinary iron, and antiferritin antibody production in the pig

“…Further examination of this table shows that the greatest excretion of iron occurs during the eight-hour period following desferrioxamine injection. This confirms the work of Yunice et al (1968) andWalsh et al (1965) who worked with other species. Very little increased iron excretion is seen due to desferrioxamine during the eighth to 16th hour period after injection, and the iron excretion is essentially at normal levels from the 16th through the 24th hour after injection.…”

“…The biochemistry of desferrioxamine and ferrioxamine was outlined by Yunice (1968). Both compounds are poorly absorbed from the gastrointestinal tract; therefore, if significant amounts of either of the compounds are to enter the body, they must be given parenterally.…”

“…Metabolism occurs largely by deamination of the free amino groups on the pentane with subsequent oxidation of the terminal carbon atom to form a carboxyl group. Deamination occurs more rapidly in the plasma than in tissues and probably involves a monamine oxidase (Yunice et al 1968).…”