Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever

Kochel, Tadeusz J.; Watts, Douglas M.; Halstead, Scott B.; Hayes, Curtis G.; Espinoza, Angelica; Felices, Vidal; Caceda, Roxana; Bautista, Christian T.; Montoya, Ysabel; Douglas, Susan; Russell, Kevin L.

doi:10.1016/s0140-6736(02)09522-3

Cited by 148 publications

(141 citation statements)

References 5 publications

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“…High antibody titers are often reported in flavivirus serologic investigations performed in geographic areas where multiple flaviviruses circulate and have been attributed to exposure to two or more flaviviruses. [52][53][54] For example, all four dengue flaviviruses are present in Mexico and patients in this region often have high PRNT titers to all serotypes. 53 It seems likely that the aforementioned horses and sheep had infections with at least two orthobunyaviruses and that the responses we detected may have been anamnestic responses.…”

Section: Discussionmentioning

confidence: 99%

Orthobunyaviruses, a Common Cause of Infection of Livestock in the Yucatan Peninsula of Mexico

Blitvich

Saiyasombat

Rosa

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. To determine the seroprevalence of selected orthobunyaviruses in livestock in the Yucatan Peninsula of Mexico, a serologic investigation was performed using serum samples from 256 domestic animals (182 horses, 31 sheep, 1 dog, 37 chickens, and 5 turkeys). All serum samples were examined by plaque reduction neutralization test using Cache Valley virus (CVV), Cholul virus (CHLV), South River virus (SOURV), Kairi virus, Maguari virus, and Wyeomyia virus. Of the 182 horses, 60 (33.0%) were seropositive for CHLV, 48 (26.4%) were seropositive for CVV, 1 (0.5%) was seropositive for SOURV, 60 (33.0%) had antibodies to an undetermined orthobunyavirus, and 13 (7.1%) were negative for orthobunyavirus-specific antibody. Of the 31 sheep, 6 (19.3%) were seropositive for CHLV, 3 (9.7%) were seropositive for CVV, 4 (12.9%) were seropositive for SOURV, 16 (51.6%) had antibodies to an undetermined orthobunyavirus, and 2 (6.5%) were negative for orthobunyavirus-specific antibody. The single dog was seropositive for SOURV. Four (11%) chickens had antibodies to an undetermined orthobunyavirus, and 1 (20%) turkey was seropositive for CHLV. These data indicate that orthobunyaviruses commonly infect livestock in the Yucatan Peninsula.

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Section: Discussionmentioning

confidence: 99%

Orthobunyaviruses, a Common Cause of Infection of Livestock in the Yucatan Peninsula of Mexico

Blitvich

Saiyasombat

Rosa

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…27,61 Even more specifically, it has been shown that disease severity in the context of a given immunological background can be affected by the genotype/clade of the DENV-2 infecting virus. 59,62 In Iquitos, a single DENV serotype typically dominates, and historically, the introduction of new DENV serotypes has resulted in epidemics of DF. These epidemics in Iquitos have been well-documented and were marked by the introduction of American DENV-2 in 1995, DENV-3 in 2001, and DENV-4 in 2008.…”

Section: Denv-2 Lineage II Peru Outbreakmentioning

confidence: 99%

Lineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon

Williams¹,

Mayer²,

Johnson³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto. These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.

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“…Epidemics in the Americas demonstrate that both viral factors and host immune states play clear roles in disease severity. Secondary infections of dengue serotype 2 have been associated with severe disease in several settings in the Americas, but only for viruses of Southeast Asian origin, not those of American origin (14)(15)(16). Because ADE appears to be a characteristic of some dengue viruses and not others, the present work seeks to explore the particular dynamic mechanisms and settings that make ADE an advantageous strategy.…”

mentioning

confidence: 99%

Dynamic effects of antibody-dependent enhancement on the fitness of viruses

Cummings

Schwartz

Billings

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

137

148

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Antibody-dependent enhancement (ADE), a phenomenon in which viral replication is increased rather than decreased by immune sera, has been observed in vitro for a large number of viruses of public health importance, including flaviviruses, coronaviruses, and retroviruses. The most striking in vivo example of ADE in humans is dengue hemorrhagic fever, a disease in which ADE is thought to increase the severity of clinical manifestations of dengue virus infection by increasing virus replication. We examine the epidemiological impact of ADE on the prevalence and persistence of viral serotypes. Using a dynamical system model of n cocirculating dengue serotypes, we find that ADE may provide a competitive advantage to those serotypes that undergo enhancement compared with those that do not, and that this advantage increases with increasing numbers of cocirculating serotypes. Paradoxically, there are limits to the selective advantage provided by increasing levels of ADE, because greater levels of enhancement induce large amplitude oscillations in incidence of all dengue virus infections, threatening the persistence of both the enhanced and nonenhanced serotypes. Although the models presented here are specifically designed for dengue, our results are applicable to any epidemiological system in which partial immunity increases pathogen replication rates. Our results suggest that enhancement is most advantageous in settings where multiple serotypes circulate and where a large host population is available to support pathogen persistence during the deep troughs of ADE-induced large amplitude oscillations of virus replication.dengue ͉ adaptive ͉ trade-off

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Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever

Cited by 148 publications

References 5 publications

Orthobunyaviruses, a Common Cause of Infection of Livestock in the Yucatan Peninsula of Mexico

Orthobunyaviruses, a Common Cause of Infection of Livestock in the Yucatan Peninsula of Mexico

Lineage II of Southeast Asian/American DENV-2 is Associated with a Severe Dengue Outbreak in the Peruvian Amazon

Dynamic effects of antibody-dependent enhancement on the fitness of viruses

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