Effect of degree of conversion on in vivo biocompatibility of flowable resin used for bioprotection of mini-implants

Santos, Rogério Lacerda dos; Meneses, Izaura Helena Chaves de; Sampaio, Gêisa Aiane de Morais; Pithon, Matheus Melo; Alves, Pollianna Muniz

doi:10.2319/112914-856.1

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…The regenerative capacity of connective tissues has been observed when their destruction occurred due to inflammatory or traumatic lesions. The main cell involved in healing is the fibroblast (Lacerda‐Santos et al, ; Lacerda‐Santos, de Meneses, Sampaio, Pithon, & Alves, ). In this experiment, there was no presence of fibroblasts in the time interval of 3 days.…”

Section: Discussionmentioning

confidence: 99%

Effect of Chenopodium ambrosioides on the healing process of the in vivo bone tissue

Penha

Santos

Carvalho

et al. 2017

Microscopy Res & Technique

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The focus of this double-blind randomized study was on evaluating the effect of an aqueous extract of Mastruz (Chenopodium ambrosioides L.) on the bone repair process in vivo. In total, 36 male Wistar rats were randomly selected for this study, and divided into 3 groups (n = 12): Group HS (Hemostatic Sponge), Group SM (Hemostatic Sponge with Mastruz) and Group BC (Blood Clot). In each animal, bone defects measuring 2 mm in diameter were performed in both tibias for placement of the substances. After 3 and 10 days, the animals were sacrificed, and the tissues were analyzed under an optical microscope relative to the following events: inflammatory infiltrate; necrosis; young fibroblasts; osteoclastic and osteoblastic activity; endosteal and periosteal bone formation; and bone repair. The results were assessed by using Kruskal-Wallis and Mann-Whitney tests (p < .05). Inflammatory infiltrate demonstrated difference between Groups SM and BC in the time interval of 3 days (p = .004); an event related to the presence of the fibrin sponge and liquid of the extract, which induced a foreign body initial reaction. The presence of young fibroblasts (p = .003), osteoclastic (p = .003), and osteoblastic (p = .020) activity was statistically significant between Groups HS and BC in the time interval of 10 days; performance was related to the presence of the sponge within bone. As regards injured bone tissue repair, Group SM demonstrated a higher level of regenerative capacity (p = 0.004), due to a larger quantities of endosteal and periosteal bone formation, demonstrated in Group SM. The aqueous extract of mastruz stimulated bone neoformation, presenting wound closure with bone tissue at the end of 10 days.

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Section: Discussionmentioning

confidence: 99%

Effect of Chenopodium ambrosioides on the healing process of the in vivo bone tissue

Penha

Santos

Carvalho

et al. 2017

Microscopy Res & Technique

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“…In the immunohistochemical analysis, the multinucleated giant cells, quantity of MGC was significantly larger from the Group RMO after the period of 30 days, when compared with the Control Group. It is suggested that it is more difficult for the monomers or other particles released by the Group RMO to be digested by the MOs, which tend to fuse and form a higher number of MGCs with the purpose of facilitating the degradation of remainders of this material (Cunha, Rached, Alfredo, León, & Perez, ; Dos Santos et al, ; Lacerda‐Santos, de Meneses, Sampaio, Pithon, & Alves, ; Lacerda‐Santos et al, ; Santos et al, ).…”

Section: Discussionmentioning

confidence: 99%

Morphological and immunohistochemical analysis of the biocompatibility of resin‐modified cements

Mesquita

Santos

Godoy

et al. 2016

Microscopy Res & Technique

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The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study. After time intervals of 7, 15, and 30 days the tissues were submitted to morphological analysis. In immunohistochemical analysis, the immuno-marking of antibody CD68 was evaluated. The results obtained were statistically analyzed by the Kruskal-Wallis and Dunn tests (p < .05). In the morphological analysis after 7 days, Groups RS, RMO and TP showed more intense inflammatory infiltrate (p = .004) and only Group RMO presented greater intensity of multinucleated giant cells (p = .027). In the immunohistochemical analysis, Groups RMO and RS were observed to present a larger quantity of CD68+ (p = .004) in the time interval of 7 days and only Group RMO presented statistically significant difference for this parameter after 15 days (p = .026). In the time interval of 30 days, Group RMO presented the largest quantity of multinucleated giant cells (p < .004). The RMGICS Crosslink and Transbond Plus provided significantly better tissue biocompatibility than the Resilience and RMO Cements.

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“…The animals were placed in EB 273C (Insight Ltd, Sao Paulo, Brazil) vivarium cabinets, with temperature control at 23 ± 1°C, 41% humidity, and were fed, during the entire period of the experiment, a solid diet of animal ration and water “ ad libitum .” 17 18 19 …”

Section: Methodsmentioning

confidence: 99%

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

et al. 2021

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Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc (p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

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Effect of degree of conversion on in vivo biocompatibility of flowable resin used for bioprotection of mini-implants

Cited by 12 publications

References 24 publications

Effect of Chenopodium ambrosioides on the healing process of the in vivo bone tissue

Effect of Chenopodium ambrosioides on the healing process of the in vivo bone tissue

Morphological and immunohistochemical analysis of the biocompatibility of resin‐modified cements

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

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