Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta-analysis of randomised controlled trials

Pasricha, Sant‐Rayn; Hayes, Emily; Kalumba, Kongolo; Biggs, Beverley‐Ann

doi:10.1016/s2214-109x(13)70046-9

Cited by 198 publications

(194 citation statements)

References 45 publications

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“…32 Iron supplementation in very young preschool children living in low-income areas may correct anemia, but a large meta-analysis of randomized trials failed to find evidence of improved cognitive performance or positive effect on growth and development. 33 In endemic malarial areas iron supplementation raises the concern of increasing parasitemia or even clinical malaria. 34 Additional well-designed studies are needed to define the benefits/risks of iron supplementation in low-income countries.…”

Section: Oral Iron Supplementationmentioning

confidence: 99%

Iron deficiency: new insights into diagnosis and treatment

2015

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Iron deficiency and iron deficiency anemia are common conditions worldwide affecting especially children and young women. In developing countries, iron deficiency is caused by poor iron intake and/or parasitic infection, whereas vegetarian dietary choices, poor iron absorption, and chronic blood loss are common causes in high-income countries. Erythropoiesis stimulating agents can result in functional iron deficiency for erythropoiesis even when stores are iron-replete. Diagnosis of iron deficiency is straightforward, except when it occurs in the context of inflammatory disorders. Oral iron salts correct absolute iron deficiency in most patients, because low hepcidin levels facilitate iron absorption. Unfortunately frequent side effects limit oral iron efficacy. Intravenous iron is increasingly utilized, because currently available preparations allow rapid normalization of total body iron even with a single infusion and are effective also in functional iron deficiency and in iron deficiency associated with inflammatory disorders. The evidence is accumulating that these preparations are safe and effective. However, long-term safety issues of high doses of iron need to be further explored. Learning Objectives• To diagnose absolute iron deficiency, iron deficiency anemia, and functional iron deficiency in the light of recent advances in iron metabolism • To evaluate advantages and disadvantages of oral and intravenous iron therapy

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Section: Oral Iron Supplementationmentioning

confidence: 99%

Iron deficiency: new insights into diagnosis and treatment

2015

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“…3 The preschool children in this region were the most vulnerable group. 4 Myanmar is the largest country in southeast Asia geographically, with over 70% of its population residing in rural areas and over 60% of the population being mothers and children. 5 The prevalence of anemia in some regions of Myanmar is reported to be unacceptably high, at around 70% in children.…”

Section: Introductionmentioning

confidence: 99%

Potential Contribution of Iron Deficiency and Multiple Factors to Anemia Among 6- to 72-Month-Old Children in the Kokang Area of Myanmar

Zhao¹,

Gao²,

Li³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. The prevalence of anemia among children in Myanmar has been reported to be among the highest in the world. This study was conducted to determine 1) the prevalence of anemia in preschool children and 2) risk factors associated with anemia. A total of 138 children aged from 6 to 72 months were recruited through cluster sampling from six villages in Kokang. Hemoglobin (Hb) concentration, blood trace elements, and anthropometric indicators were measured. Feces samples were collected to examine for the presence of ascarid eggs. The overall prevalence of anemia in children was 61.6%, including 10.9% with severe anemia. Meanwhile, high prevalence of stunting (40.0%), underweight (22.4%), wasting (6.3%), and small head circumference (6.7%) was found. Children with anemia were more prone to stunting. Children with severe anemia and moderate anemia had significantly lower blood iron and zinc levels than children without anemia (P < 0.001 and P = 0.007). The prevalence of ascarid infection was 64.9%; however, it was not associated with anemia. Drinking spring water was positively associated with anemia (odds ratio [OR] = 6.368). This study demonstrated that anemia is an important public health problem among children from the Kokang area. Iron deficiency and drinking spring water may be the important causes of anemia among children.

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“…Children with immune system disorders are more susceptible to infectious diseases, thus affecting nutritional status. (24) A low adequacy level for zinc is a risk factor for stunting in comparison with respondents with a adequate adequacy level for zinc. Our study results are in agreement with the study conducted by Hidayati, (7) stating that low zinc intake carries a 2.67-fold higher risk for stunting incidence in children.…”

Section: Discussionmentioning

confidence: 99%

Zinc deficiency as risk factor for stunting among children aged 2-5 years

Bening

Margawati

Rosidi

2017

UnivMed

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BACKGROUNDStunting is a nutritional problem in the form of linear growth disturbance caused by low intake of macro-and micronutrients. The prevalence of stunting in children aged 2-5 years in Semarang is higher in well-to-do families (67.2%) than in poor families (32.8%). The purpose of this study was to analyze the role of low adequacy levels of vitamin C, iron, zinc and low food expenditure as risk factors of stunting among children aged 2-5 years.

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Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta-analysis of randomised controlled trials

Abstract: Victoria Fellowship (Government of Victoria, Australia); CRB Blackburn Scholarship (Royal Australasian College of Physicans); Overseas Research Experience Scholarship, University of Melbourne.

Cited by 198 publications

References 45 publications

Iron deficiency: new insights into diagnosis and treatment

Iron deficiency: new insights into diagnosis and treatment

Potential Contribution of Iron Deficiency and Multiple Factors to Anemia Among 6- to 72-Month-Old Children in the Kokang Area of Myanmar

Zinc deficiency as risk factor for stunting among children aged 2-5 years

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