Effect of daily clenbuterol and exogenous melatonin treatment on body fat, serum leptin and the expression of seasonal anestrus in the mare

McManus, Christina J.; Fitzgerald, B. P.

doi:10.1016/s0378-4320(02)00246-4

Cited by 18 publications

(25 citation statements)

References 25 publications

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“…Anyway, it appears that salbutamol did not possess a potent anabolic effect in vivo in humans after oral intake. In parallel, a number of animal studies [2,16,20,21] demonstrated a significant decrease in fat mass after chronic beta-agonist administration, with a possible direct inhibition in leptin gene expression [11]. However, although we found a high correlation for all subjects between leptin and percent fat mass, we did not find any change in fat mass or in basal leptin concentrations after SAL intake.…”

Section: Discussionsupporting

confidence: 61%

“…Chronic administration of specific β 2 -adrenergic agonists, especially clenbuterol and salmeterol, has been shown to increase skeletal muscle strength and size in several species following relatively short periods of administration [4,19 -21]. In addition, chronic treatment with β 2 -agonist was associated with a decline in body fat [2,16,20,21] and circulating concentrations of leptin [16] in animals, with a possible direct inhibition in leptin gene expression [11] by this class of drug.To our knowledge, only a few studies have examined the effects of chronic oral salbutamol intake in healthy non-asthmatic human subjects on body composition and a possible relationship with performance during anaerobic exercise. As a matter of fact, there are two studies [5,13] which demonstrate that chronic salbutamol intake does not lead to any change in body weight and composition but does increase voluntary muscle strength in man during static exercise.…”

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confidence: 99%

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Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Panse¹,

Collomp²,

Portier³

et al. 2005

Int J Sports Med

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The effects of a chronic salbutamol intake (SAL, 12 mg/d during 3 weeks) on changes in body composition, metabolic indices and performance during a 30-second Wingate test were determined in 8 strength-trained male athletes (T) and 7 sedentary male (UT) subjects, according to a double-blind, randomized, cross-over protocol. Blood samples were collected both at rest, at the end of the test, and during passive recovery (5 min, 10 min, 15 min) for leptin (at rest), and blood lactate measurements. No significant changes in lean body mass, fat mass, and leptin were observed with SAL treatment in either group during the trial. Peak power was significantly increased (p < 0.05) after SAL intake in all subjects (T: 11.9 %; UT: 8.3 %) with a decrease in time to peak power with SAL compared to placebo (PLA) (p < 0.05). There was no change in total work performed and in fatigue indices with SAL compared to PLA. Blood lactate was significantly increased after SAL vs. PLA during the recovery (p < 0.05) in all subjects. The data demonstrate that the chronic administration of therapeutic levels of salbutamol increases maximal anaerobic power in man, irrespective of the subjects' training status. This study also rules out any implication of an anabolic effect in this improvement in performance during supramaximal exercise. Further studies are necessary to clarify the mechanisms involved.

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Section: Discussionsupporting

confidence: 61%

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confidence: 99%

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confidence: 99%

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Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Panse¹,

Collomp²,

Portier³

et al. 2005

Int J Sports Med

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“…However, the specific mechanisms that mediate reproductive and immune functions remain unclear [2]. Classic knowledge, for example, involving melatonin [3,4] is unable to explain completely all the reproductive and immunological events. Thus, other factors involved in regulation of immune and reproductive functions should be investigated by considering the seasonal modifications of these functions.…”

Section: Introductionmentioning

confidence: 99%

Blood Levels of Selected Metabolic Factors, Cytokines, and Lymphocyte Subpopulations in Arabian and Thoroughbred Horses During the Longest and Shortest Days of the Year

Üner

Sulu

Altinsaat

et al. 2013

Journal of Equine Veterinary Science

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“…Conversely, the effect of photoperiod or exogenous melatonin on the time of the last ovulation in autumn is controversial. In adult mares, melatonin treatment fails to change the date of the last ovulation [41,42]. In horses [12,14,39,41,43-48], as in ewes [49], different experimental approaches indicate that the annual reproductive rhythm has a strong endogenous component.…”

Section: Introductionmentioning

confidence: 99%

Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus)

Salazar-Ortiz

Camous

Briant

et al. 2011

Reprod Biol Endocrinol

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BackgroundMares have an annual reproductive rhythm, with a phase of inactivity in midwinter. The aim of this study was to determine the impact of food restriction on physiological and metabolic hallmarks of this rhythm.MethodsOver three successive years, 3 groups of 10 mares were kept under natural photoperiod. A 'well-fed' group was fed to maintain the mares in good body condition; a 'restricted' group received a diet calculated to keep the mares thin and a 'variable' group was fed during some periods like the 'restricted' group and during some other periods like the 'well-fed' group, with the aim of mimicking the natural seasonal variation of pasture availability, but a few months in advance of this natural rhythm.ResultsWinter ovarian inactivity always occurred and was long in the restricted group. In contrast, in the 'well-fed' group, 40% of mares showed this inactivity, which was shorter than in the other groups. Re-feeding the 'variable' group in autumn and winter did not advance the first ovulation in spring, compared with the 'restricted' group. Measurements of glucose and insulin concentrations in mares from the 'restricted' group during two 24 h periods of blood sampling, revealed no post-prandial peaks. For GH (Growth hormone), IGF-1 and leptin levels, large differences were found between the 'well-fed' group and the other groups. The glucose, insulin, GH and leptin levels but not melatonin level are highly correlated with the duration of ovulatory activity.ConclusionsThe annual rhythm driven by melatonin secretion is only responsible for the timing of the breeding season. The occurrence and length of winter ovarian inactivity is defined by metabolic hormones.

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Effect of daily clenbuterol and exogenous melatonin treatment on body fat, serum leptin and the expression of seasonal anestrus in the mare

Cited by 18 publications

References 25 publications

Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Blood Levels of Selected Metabolic Factors, Cytokines, and Lymphocyte Subpopulations in Arabian and Thoroughbred Horses During the Longest and Shortest Days of the Year

Effects of nutritional cues on the duration of the winter anovulatory phase and on associated hormone levels in adult female Welsh pony horses (Equus caballus)

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