Blood Levels of Selected Metabolic Factors, Cytokines, and Lymphocyte Subpopulations in Arabian and Thoroughbred Horses During the Longest and Shortest Days of the Year

Üner, Aykut Göktürk; Sulu, Nesrin; Altinsaat, Çiğdem; Eyibilen, Ahmet

doi:10.1016/j.jevs.2013.03.001

Cited by 5 publications

(14 citation statements)

References 48 publications

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“…CD3D and CD3G coding genes showed elevated transcript levels in the current study, which are involved in TCR activation [53]. Moreover, Aykut et al also documented that male horses had higher CD3 expression level during breeding season [22]. The upregulation of IL1R2 was found in T-cell activation [53], and IL1R2 was up-regulated in male giant pandas.…”

Section: Adaptive Immune Changessupporting

confidence: 65%

“…Integration of down-regulated inhibitor and up-regulated activator may imply the partial activation states of NK cells. The increased expression level of NK cells was also reported in breeding horses, suggesting a slightly increased innate immunity in the breeding season [22].…”

Section: Innate Immune Changesmentioning

confidence: 53%

“…During the breeding season, males tree lizards reduced innate immunity in the laboratory [3], while the innate immunity showed no change in male Eurasian tree sparrows and temperate bat [6,21]. Arabian and Thoroughbred horses presented a increased innate immunity [22]. Considering methodological difference, we explored the alteration of innate immunity from several aspects and found an enhanced innate immunity in male giant pandas.…”

Section: Innate Immune Changesmentioning

confidence: 95%

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Immune profiles of male giant panda (Ailuropoda melanoleuca) during breeding season

Shen

et al. 2020

Preprint

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Background The giant panda (Ailuropoda melanoleuca), regarded as the flagship species of conservation, is a most threatened species endemic to China. Life history theory proposes that reproduction and immunity can be mutually constraining and interrelated. The immunity changes of male giant pandas during reproduction is not clear. Results Here, we did research on peripheral blood gene expression profiles associated with immunity. 13 giant pandas with ages ranging from 9 to 11 years old were divided into two groups depending on whether or not they were in breeding season. We identified 318 up-regulated DEGs and 43 down-regulated DEGs, which were enriched in 87 GO terms and 6 KEGG pathways. What’s more, we obtained 45 immune-related genes with altered expression, mostly up-regulated, and identified four hub genes HSPA4, SUGT1, SOD1 and IL1B in PPI analysis. These genes were related to pattern recognition receptors, autophagy, peroxisome, proteasome, natural killer cell, antigen processing and presentation. Our results suggest that most immune-related genes were up-regulated and more related to innate immune than adaptive immune. Conclusions Male giant pandas presented an immunoenhancement in innate immunity, enhanced antigen presentation and processing in cellular immunity, and a low humoral immunity during breeding season. This study will provide a foundation for further studies of immunity and reproduction in giant pandas.

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Section: Adaptive Immune Changessupporting

confidence: 65%

Section: Innate Immune Changesmentioning

confidence: 53%

Section: Innate Immune Changesmentioning

confidence: 95%

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Immune profiles of male giant panda (Ailuropoda melanoleuca) during breeding season

Shen

et al. 2020

Preprint

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“…This may indicate a trend of more pro-inflammatory and less regulatory cytokines in females. This is still a controversial issue in horses (Hamza et al, 2008;Uner et al, 2013;Wray et al, 2013), but is in line with higher plasma levels of TNF␣ found in mares than in geldings of mixed breeds and ages (Suagee et al, 2013).…”

Section: Sex Is Relevant For Some Immunological Parametersmentioning

confidence: 84%

Influences of age and sex on leukocytes of healthy horses and their ex vivo cytokine release

Schnabel

Steinig

Schuberth

et al. 2015

Veterinary Immunology and Immunopathology

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“…No nosso trabalho, apenas as ENL eram obesas no final da gestação, porém não observamos diferença na leptinemia dos potros entre os dois grupos. Também não observamos, como já relatado em trabalhos anteriores, correlação entre leptina e IGF-1 neonatais (UNER et al, 2013) e leptina materna com peso ao nascimento . Assim como Smith et al, 2017 não encontramos correlação entre leptina materna e triglicérides e leptina neonatal.…”

Section: Correlaçãounclassified

>b<Avaliação da dinâmica insulina-glicose, citocinas inflamatórias e marcadores metabólicos em éguas gestantes e seus potros>/b<

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Blood Levels of Selected Metabolic Factors, Cytokines, and Lymphocyte Subpopulations in Arabian and Thoroughbred Horses During the Longest and Shortest Days of the Year

Cited by 5 publications

References 48 publications

Immune profiles of male giant panda (Ailuropoda melanoleuca) during breeding season

Immune profiles of male giant panda (Ailuropoda melanoleuca) during breeding season

Influences of age and sex on leukocytes of healthy horses and their ex vivo cytokine release

>b<Avaliação da dinâmica insulina-glicose, citocinas inflamatórias e marcadores metabólicos em éguas gestantes e seus potros>/b<

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