Effect of Daidzein in Rats on Cadmium Excretion

Om, Ae-Son; Shim, Jae-Young

doi:10.1007/s00128-007-9098-6

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…In addition, flavonoids protect bones by decreasing serum osteocalcin, restoring absorption of metal ions by bone cells, and maintaining balance. Genistein increased the weight of the femur and prevented Cd‐induced bone loss by improving excretion of urinary and fecal Cd owing to the formation of insoluble compounds of Cd with hydroxyl groups . Genistein effectively inhibited the increase in serum calcium concentration by inhibiting the release of calcium from the bone in ovariectomized female Wistar rats treated with Cd.…”

Section: Nutritional Intervention For Osteoporosismentioning

confidence: 86%

“…Treatment with daidzein (10 mg/100 g of feed) alleviated Cd toxicity in ovariectomized rats by increasing the excretion of Cd via urine and feces. 57 Both genistein and daidzein had a protective effect in Cd-exposed ovariectomized rats in growth periods by stimulating Cd excretion.…”

Section: Isoflavonesmentioning

confidence: 97%

“…Co‐treatment with genistein created normal proliferative cartilage and hypertrophic cell distribution and inhibited Ca excretion from bone to prevent bone loss. Treatment with daidzein (10 mg/100 g of feed) alleviated Cd toxicity in ovariectomized rats by increasing the excretion of Cd via urine and feces . Both genistein and daidzein had a protective effect in Cd‐exposed ovariectomized rats in growth periods by stimulating Cd excretion.…”

Section: Dietary Flavonoidsmentioning

confidence: 99%

“…Genistein increased the weight of the femur and prevented Cd-induced bone loss by improving excretion of urinary and fecal Cd owing to the formation of insoluble compounds of Cd with hydroxyl groups. 56,57 Genistein effectively inhibited the increase in serum calcium concentration by inhibiting the release of calcium from the bone in ovariectomized female Wistar rats treated with Cd. Catechins reduced serum osteocalcin, restored the content of bone calcium and other minerals, decreased the bone formation index, and increased bone mineral density to effectively eliminate the bone metabolism disorder caused by excessive Cd.…”

Section: Nutritional Intervention For Osteoporosismentioning

confidence: 99%

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Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Jiang

Sun

et al. 2017

Annals of the New York Academy of Sciences

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Cadmium (Cd) damages the liver, kidney, bones, reproductive system, and other organs. Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods, have shown protective effects against Cd-induced damage. The cytoprotective effects of flavonoids against Cd-induced diseases are mainly attributable to three mechanisms. First, flavonoids clear reactive oxygen species, thereby reducing lipid peroxide production and improving the activity of antioxidation enzymes. Second, flavonoids chelate Cd, thus reducing the accumulation of Cd and altering the levels of other essential metal ions in vivo. Third, flavonoids reduce DNA damage and inhibit apoptosis. In addition, flavonoids were found to inhibit inflammation and fibrosis and improve glycometabolism and the secretion of reproductive hormones. We introduce the daily dosage and absorption rate of flavonoids and then focus on their bioactive effects against Cd-induced toxicity and reveal the underlying metabolic pathway, which provides a basis for further study of the nutritional prevention of Cd-induced injury. In particular, a better understanding is needed of the structure-activity relationship of flavonoids against Cd toxicity, which has not yet been reported.

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Section: Nutritional Intervention For Osteoporosismentioning

confidence: 86%

Section: Isoflavonesmentioning

confidence: 97%

Section: Dietary Flavonoidsmentioning

confidence: 99%

Section: Nutritional Intervention For Osteoporosismentioning

confidence: 99%

See 2 more Smart Citations

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Jiang

Sun

et al. 2017

Annals of the New York Academy of Sciences

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“…Chelation of isoflavones, daidzein and genistein, with Cu(II) and Fe(III) were attempted by Mira et al but revealed no chelation in their spectrophotometric chelation studies [10]. Other studies have been found to be inconclusive as regards isoflavone metal chelation often looking at indirect factors such as cadmium excretion levels being reduced by daidzein [13] or inhibition of metal ions with genistein on α-glucosidase [14]. The research presented here broadens the knowledge of other isoflavone ligand species that can chelate with transition metal species and represents the first direct evidence for isoflavone metal chelation between Cu(II) with genistein and Fe(III) with biochanin A and genistein.…”

Section: Introductionmentioning

confidence: 96%