Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin

Renugadevi, J.; Prabu, S. Milton

doi:10.1016/j.etp.2009.03.010

Cited by 332 publications

(245 citation statements)

References 51 publications

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“…The protective effect of AME can be explained by its high content of polyphenolic compounds, especially including anthocyanins, which possess strong antioxidative potential [13,14,[18][19][20]. Polyphenols act as direct free radical scavengers [20], inhibit the activities of pro-oxidative enzymes [20], and increase antioxidative enzyme activities [3,8,9] as well as play a role in the regeneration of antioxidative vitamins (vitamin C and E) [29,30]. The observations made in the animals receiving AME alone revealed the effectiveness of the extract in the improvement of the antioxidative system of the bone tissue.…”

Section: Figmentioning

confidence: 99%

“…Owing to the large number of -OH groups, these compounds are capable of chelating metal ions, including Cd 2+ [4,6,14]. It has been revealed that some food products abundant in polyphenolic compounds, including especially green tea and soybeans, may offer protection against various effects of exposure to Cd; however, the data is very sparse and refers only to chosen compounds [3,[5][6][7][8][9][15][16][17].…”

mentioning

confidence: 99%

“…Evidence that even relatively low exposure to Cd contributes to osteoporosis and bone fractures [10][11][12] together with forecasts that the general populationʼs exposure to this element will increase [2] are reasons that growing attention has been focused on searching for an effective means of protection from the unfavorable action of this xenobiotic, including damage to the skeleton. It seems that polyphenols, being the most abundant bioactive components in our diet [13,14], are a promising group of compounds playing a role in this protection [3][4][5][6][7][8][9]15]. Owing to the large number of -OH groups, these compounds are capable of chelating metal ions, including Cd 2+ [4,6,14].…”

mentioning

confidence: 99%

“…Recently, the possibility of using natural plant ingredients for protection against the dangerous action of xenobiotics to which humans are exposed throughout their lifetime, including Cd, which is one of the most toxic heavy metals, has been of special interest to researchers [1][2][3][4][5][6][7][8][9]. Evidence that even relatively low exposure to Cd contributes to osteoporosis and bone fractures [10][11][12] together with forecasts that the general populationʼs exposure to this element will increase [2] are reasons that growing attention has been focused on searching for an effective means of protection from the unfavorable action of this xenobiotic, including damage to the skeleton.…”

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confidence: 99%

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The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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!Recently, we demonstrated in a rat model that consumption of a polyphenol-rich extract obtained from the berries of Aronia melanocarpa could protect from cadmium-induced disorders in bone turnover and changes in bone mineral status. The aim of this study was to investigate whether the osteoprotective effect of this extract is mediated by the oxidative defense system. Enzymatic and nonenzymatic antioxidants, total antioxidative and oxidative status, hydrogen peroxide, and markers of oxidative protein, lipid, and DNA damage were determined in bone tissue at the distal femoral epiphysis of female Wistar rats receiving 0.1 % aqueous A. melanocarpa extract (prepared from the lyophilized commercial extract containing 65.74 % of polyphenols) as the only drinking fluid and/or cadmium in the diet (1 and 5 mg/kg) for 3, 10, 17, and 24 months. The total oxidative and antioxidative status of the serum was also evaluated. The administration of A. melanocarpa extract provided significant protection from cadmium-induced oxidative stress in the bone and serum, and from lipid peroxidation and oxidative damage to the protein and DNA in the bone tissue. Numerous correlations were noted between indices of the oxidative/antioxidative bone status and markers of bone metabolism previously assayed in the animals receiving A. melanocarpa extract. The results allow the conclusion that the ability of A. melanocarpa extract to mediate the oxidative defense system and prevent oxidative modifications of protein, lipid, and DNA in the bone tissue plays an important role in its osteoprotective action under exposure to cadmium. The findings provide further evidence supporting our suggestion that chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal. Abbreviations

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Section: Figmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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“…The toxic effect of Cd is controlled by the oxidation of cellular organelles by generating ROS reactions which lead to lipid peroxidation, apoptosis, damage of DNA and altered gene expression (Stohs et al, 1999;Wu et al, 2002;Thévenod, 2003). Therefore, to relieve Cd adverse effect the antioxidants induction is considered as an important therapeutic approach (Renugadevi and Prabu, 2010;Sinha et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The protective role of honey against cytotoxicity of cadmium chloride in mice

Shahrour¹,

Zowail²,

Sharafeldin³

2016

Afr. J. Biotechnol.

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The present study aimed to investigate the honey (HY) protective role in opposition to cadmium (Cd) induced chromosomal aberrations of bone marrow and sperm abnormalities. Forty five (45) adult male albino mice were caged into six groups. Mice were injected, i.p, 300 mg HY/kg and/or 0.67 mg CdCl 2 /kg b.w for 96 h, separately and alternated. The alternated trials were continued for consecutive eight days. Results show that mice injected with cadmium had significant increase in the frequency of aberrant chromosomes as fragment, centric fusion, gap, stickiness and aneuploidy and in sperm abnormality. The administration of HY improved the frequency of the chromosomal aberrations and sperm abnormality induced by Cd.

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Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity

Haeri

Karimi

Oskoueian³

2022

Biotech and App Biochem

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In the present research, we encapsulated a flavonoid called kaempferol into nanoliposomal structures and the health‐promoting effects of synthesized nanoliposome‐loaded kaempferol (NLK) were evaluated in mice challenged by cadmium‐induced . The NLK characteristics, such as size, zeta potential, and polydispersity index, were 218.4 nm, −28.55 mV, and 0.29, respectively. The in vivo experiment revealed that the mice receiving water containing cadmium (2 mg/kg body weight/day) showed significant (p < 0.05) weight loss, an increase in liver enzyme activities, and hepatic oxidative stress. Dietary supplementation with NLK at concentrations of 2.5 and 5 mg/kg mice body weight notably (p < 0.05) improved the body weight, liver enzyme activities, hepatic oxidative stress, and antioxidant potential of the liver. Our findings elucidated that NLK could alleviate the toxicity of cadmium in mice challenged by cadmium‐induced toxicity.

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Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin

Cited by 332 publications

References 51 publications

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

The protective role of honey against cytotoxicity of cadmium chloride in mice

Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity

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