Effect of cyanide ions (CN-) extracted from cassava (Manihotesculenta Crantz) on Alveolar Epithelial Cells (A549 cells)

Joseph, Tessy; Sreejith, Sivaramapanicker; Joseph, X.; Sangeetha, V.P.; Prajitha, N.; Vandana, Unnikrishnan; Jayaprakas, C. A.; Mohanan, P.V.

doi:10.1016/j.tox.2021.153019

Cited by 2 publications

(4 citation statements)

References 45 publications

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“…49 Similarly, cytotoxic activity was also demonstrated by hydrogen cyanide derived from the cyanogenic glycosides isolated using gas chromatography from distillation cassava leaf extract. 38 Figure 6 shows the structures of stilbene derivative (resveratrol), saponin (diosgenin), and cyanogenic glycosides (linamarin and lotaustralin) isolated from cassava.…”

Section: Resultsmentioning

confidence: 99%

“…Cassava cyanide extract (CCE) also demonstrated significant anti-proliferative activity in adenocarcinoma human alveolar basal epithelial cells (A549) at a concentration of 400 ppm using MTT and neutral red uptake (NRU) assay. 38 Uniquely, Maesculentins A and B were isolated from the stems of cassava extract in a study conducted by Pan et al (2015), and both components demonstrated moderate cytotoxic activity against the HGC-27 tumor cell line. Although there is a lack of research on their mechanism of action, the study proposed that the unsaturation of the chemical structure may significantly contribute to their anti-cancer property.…”

Section: Discussionmentioning

confidence: 99%

“…Chemical Components Summary of Cassava. 19,22,23,25,31,33,34,38,40,45,[47][48][49]53,88,89,93,[95][96][97][98] Phytochemical groups Components Plant part Extraction methods/solvent used References…”

Section: Phytochemistrymentioning

confidence: 99%

“…Cassava cyanide extract (CCE) also demonstrated significant anti-proliferative activity in adenocarcinoma human alveolar basal epithelial cells (A549) at a concentration of 400 ppm using MTT and neutral red uptake (NRU) assay. 38 Uniquely, Maesculentins A and B were isolated from the stems of cassava extract in a study conducted by Pan et al (2015), and • Water is added to cassava with a ratio of 1:10. This is followed by blending at high speed until a smooth slurry is made.…”

Section: Phytochemistrymentioning

confidence: 99%

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Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry

Mohidin,

Moshawih,

Hermansyah

et al. 2023

J Evid Based Complementary Altern Med

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Cassava ( Manihot esculenta Crantz) is considered one of the essential tuber crops, serving as a dietary staple food for various populations. This systematic review provides a comprehensive summary of the nutritional and therapeutic properties of cassava, which is an important dietary staple and traditional medicine. The review aims to evaluate and summarize the phytochemical components of cassava and their association with pharmacological activities, traditional uses, and nutritional importance in global food crises. To collect all relevant information, electronic databases; Cochrane Library, PubMed, Scopus, Web of Science, Google Scholar, and Preprint Platforms were searched for studies on cassava from inception until October 2022. A total of 1582 studies were screened, while only 34 were included in this review. The results of the review indicate that cassava has diverse pharmacological activities, including anti-bacterial, anti-cancer, anti-diabetic, anti-diarrheal, anti-inflammatory, hypocholesterolemic effects, and wound healing properties. However, more studies that aim to isolate the phytochemicals in cassava extracts and evaluate their pharmacological property are necessary to further validate their medical and nutritional values.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

“…Cassava cyanide extract (CCE) also demonstrated significant anti-proliferative activity in adenocarcinoma human alveolar basal epithelial cells (A549) at a concentration of 400 ppm using MTT and neutral red uptake (NRU) assay. 38 Uniquely, Maesculentins A and B were isolated from the stems of cassava extract in a study conducted by Pan et al (2015), and • Water is added to cassava with a ratio of 1:10. This is followed by blending at high speed until a smooth slurry is made.…”

Section: Phytochemistrymentioning

confidence: 99%

See 2 more Smart Citations

Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry

Mohidin,

Moshawih,

Hermansyah

et al. 2023

J Evid Based Complementary Altern Med

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Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia

et al. 2022

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Background and Aim: The utilization of cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves from Bojonegoro Regency has led to the poisoning of livestock due to antinutritional factors. Nevertheless, the plants are known to have bioactive components and potential antioxidant and antibacterial activity if appropriately processed. This study aimed to determine the antinutritional compounds as well as the antioxidant and antibacterial potential of these plants responsible for livestock poisoning in the Bojonegoro Regency. Materials and Methods: Extraction was performed by the maceration method using 70% (v/v) ethanol solvent. The samples were analyzed qualitatively to determine the presence of tannins, alkaloids, oxalates, cardiac glycosides, and cyanogenic glycosides. The antioxidant activity was determined using the 1,1-diphenyl-2-picrylhydrazyl method, while the antimicrobial activity was assessed by different testing concentrations (125, 250, and 500 mg/mL) against Staphylococcus epidermidis, Staphylococcus aureus, and Escherichia coli. Results: The ethanolic extract of the plants was found to contain antinutritional tannins, alkaloids, cardiac glycosides, and cyanogenic glycosides suspected of causing livestock poisoning. Despite the presence of these antinutrients, all extracts also had antioxidant and antibacterial potential. Cassava peels and sweet potato leaves had the highest antioxidant activity, whereas Chinese Albizia leaves had the most potent antibacterial activity. Conclusion: Cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves obtained from Bojonegoro Regency and used as agricultural waste contain antinutritional factors but also possess potentially effective antioxidant and antimicrobial components.

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Effect of cyanide ions (CN-) extracted from cassava (Manihotesculenta Crantz) on Alveolar Epithelial Cells (A549 cells)

Cited by 2 publications

References 45 publications

Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry

Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry

Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia

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