Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Srivatsan, Kunnavakkam Vinjimur; Duraipandy, Natarajan; Begum, Shajitha; Lakra, Rachita; Ramamurthy, Usha; Korrapati, Purna Sai; Kiran, Manikantan Syamala

doi:10.1016/j.ijbiomac.2015.01.050

Cited by 45 publications

(22 citation statements)

References 58 publications

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“…In addition, AgNPs provide multiple sites of attachments, while most cross-linking agents only provide two point connections between the collagen molecules [11,12]. Previous studies showed that AgNPs have the ability to increase the stability of collagen, modulating the alignment and development of the newly formed collagen fibres [13][14][15]. Moreover, AgNPs improve the resistance of different polymers to calcification, and provide them with anti-inflammatory and anti-bacterial properties [16,17].…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Saleh

Ahmed

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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No ideal cross-linking agent has been identified for decellularized livers (DLs) yet. In this study, we evaluated structural improvements and biocompatibility of porcine DLs after cross-linking with silver nanoparticles (AgNPs). Porcine liver slices were decellularized and then loaded with AgNPs (100 nm) after optimization of the highest non-toxic concentration (5 µg/mL) using Human hepatocellular carcinoma (HepG2) and EAhy926 human endothelial cell lines. The cross-linking effect of AgNPs was evaluated and compared to that of glutaraldehyde and ethyl carbodiimide hydrochloride and N-hydroxysuccinimide. The results indicated that AgNPs improved the ultra-structure of DLs' collagen fibres with good porosity and increased DLs' resistance against in vitro degradation with good cytocompatibility. AgNPs decreased the host inflammatory reaction against implanted porcine DL slices in vivo and increased the polarization of M2 macrophages. Thus, structural and functional improvements of Porcine DLs could be achieved using AgNPs.

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Section: Introductionmentioning

confidence: 99%

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Saleh

Ahmed

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…The tensile strength of collagen can be further improved with functionalized silver nanoparticles [66] or curcumin-caged silver nanoparticles [67]. Both approaches resulted in a biocompatible network which enabled cells to proliferate and even inhibited microbial growth, making nanoparticle-functionalized collagen hydrogels promising candidates in wound dressing applications [66,67].…”

Section: Biohybrid Fibrin and Collagen Hydrogelsmentioning

confidence: 99%

“…Both approaches resulted in a biocompatible network which enabled cells to proliferate and even inhibited microbial growth, making nanoparticle-functionalized collagen hydrogels promising candidates in wound dressing applications [66,67].…”

Section: Biohybrid Fibrin and Collagen Hydrogelsmentioning

confidence: 99%

Hydrogels based on collagen and fibrin – frontiers and applications

Schneider-Barthold¹,

Baganz²,

Wilhelmi

et al. 2016

BioNanoMaterials

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Hydrogels are a versatile tool for a multitude of applications in biomedical research and clinical practice. Especially collagen and fibrin hydrogels are distinguished by their excellent biocompatibility, natural capacity for cell adhesion and low immunogenicity. In many ways, collagen and fibrin represent an ideal biomaterial, as they can serve as a scaffold for tissue regeneration and promote the migration of cells, as well as the ingrowth of tissues. On the other hand, pure collagen and fibrin materials are marked by poor mechanical properties and rapid degradation, which limits their use in practice. This paper will review methods of modification of natural collagen and fibrin materials to next-generation materials with enhanced stability. A special focus is placed on biomedical products from fibrin and collagen already on the market. In addition, recent research on the in vivo applications of collagen and fibrin-based materials will be showcased.

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“…New method of silver nanoparticles preparation using aqueous plant extract of Ailanthus altissima was also reported . Silver nanoparticles have anti‐inflammatory and antimicrobial properties . Silver ions interact with thiol groups of enzymes and proteins and disrupt the respiration process and transportation of substances across bacterial cells .…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of collagen/chitosan composites with silver nanoparticles

2019

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In this work, thin films made from the blends of collagen and chitosan with silver nanoparticles were prepared and their properties, which are important for potential biomedical applications, were studied. Thin biopolimeric film was obtained by solvent evaporation from collagen/chitosan mixture containing silver nanoparticles. Mechanical properties of the composites were tested in dry condition using a mechanical testing machine. Microstructure of films was analyzed by Atomic Force Microscope. The surface properties were analyzed by contact angle measurements using hydrophilic and hydrophobic liquids. In addition, antimicrobial properties of collagen/chitosan/silver composites were tested during the microbiological test. It was found that the addition of silver nanoparticles to collagen/chitosan film affects several of its properties. Microbiological studies showed that obtained collagen/chitosan/silver nanoparticles materials possess bacteriostatic activity against Staphylococcus aureus.

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Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications

Cited by 45 publications

References 58 publications

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Hydrogels based on collagen and fibrin – frontiers and applications

Preparation and characterization of collagen/chitosan composites with silver nanoparticles

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