Effect of Cryotherapy on Tracheal Tumors in Rats

History of cryosurgery

“…Dermatological cryosurgery, commonly using simple hand-held devices cooled by liquid nitrogen, became accepted practice [96][97][98]. Continued interest was evident in the treatment of bronchopulmonary disease, especially with endoscopy, though the work was principally in experimental animals [99][100][101][102][103]. Early in the 1970s, clinical trial of the effects of cryosurgery on the endometrium for the purpose of treating dysfunctional uterine bleeding was reported by Droegemuller et al [104].…”

Endobronchial Cryotherapy

“…[6][7][8][9][10][11][12] Endobronchial disease remained somewhat inaccessible due to the relative difficulty of reaching the components of the tracheobronchial tree with the tools available, however, and also due to concerns regarding the extent of healing in tissues with ciliated endothelia, such as the trachea and bronchi. The restoration of normal epithelia after cryotreatment in experimental studies of dogs was later reported by several workers, [13][14][15][16][17][18][19] and later Sanderson et al 20 reported the first instance of the use of cryotherapy for the amelioration of obstructive airway tumors, followed shortly by another case reported by Sanderson in 1975. By 1977, the first quantitative study of 28 patients treated in this way concluded that cryotherapy could serve as a useful palliative treatment for endoluminally obstructive tracheobronchial carcinoma.…”

Purification and partial characterization of a liver cell proliferation factor called hepatopoietin

“…Moolten and Bucher [6] and Grisham et al [7] demonstrated in parabiotic experiments that circulating blood of a partially hepatectomized rat stimulates DNA synthesis and mitosis in the liver of the normal rat. Other research groups investigated the influence of the pancreas on liver regeneration [8,9]. Bucher and Swaffield [ 101 showed that partially hepatectomized rats, with resected pancreas, underwent a normal liver regeneration after additional infusion of insulin and glucagon.…”