Semin. Surg. Oncol.
 1998
DOI: 10.1002/(sici)1098-2388(199803)14:2<99::aid-ssu2>3.0.co;2-1
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History of cryosurgery

Andrew A. Gage
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Cited by 179 publications

(74 citation statements)
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“…We also acknowledge that cryoneurolysis was not superposed on a model of pain, and so we could not evaluate its impact on pain relief. Finally, while modern clinical deployment of cryoneurolysis is frequently ultrasound guided and percutaneous, we acknowledge that the peroneal nerve was exposed during cryoneurolysis, an approach more commonly performed by surgeons in earlier studies 5. Percutaneous insertion of currently-available cryo-delivery cannulas would have been more challenging at the small scale of rat limbs; our technique enabled more consistent placement of the cannula on its target, providing us more confidence in our subsequent results.…”
Section: Discussion
mentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We also acknowledge that cryoneurolysis was not superposed on a model of pain, and so we could not evaluate its impact on pain relief. Finally, while modern clinical deployment of cryoneurolysis is frequently ultrasound guided and percutaneous, we acknowledge that the peroneal nerve was exposed during cryoneurolysis, an approach more commonly performed by surgeons in earlier studies 5. Percutaneous insertion of currently-available cryo-delivery cannulas would have been more challenging at the small scale of rat limbs; our technique enabled more consistent placement of the cannula on its target, providing us more confidence in our subsequent results.…”
Section: Discussion
mentioning
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…With the latest generation microwave antenna, a spherical shaped ablation zone with a short axis diameter of up to 4 cm can be achieved [80]. Cryoablation is based on local tissue destruction based on very low temperatures inducing cellular dehydration, protein denaturation and microcirculatory failure [81].…”
Section: Results
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Cryoanalgesia has been used for decades for pain relief in the chronic pain population. 4 It was applied for postoperative analgesia in the 1980s by applying a cryoneurolysis probe directly to surgically exposed nerves. 5 A percutaneous approach 6 became possible with probes specifically designed for this use combined with ultrasound guidance.…”
Section: Discussion
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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