Effect of crocus sativus on gentamicin induced nephrotoxicity

Abstract

Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent.

Antioxidant activity and protective effects of commercial propolis on gentamicin induced nephrotoxicity in rabbits- In vitro study

“…In addition, vascular changes in the form of congestion, thrombosis with perivascular edema and interstitial hemorrhages were also detected. These microscopic changes were in agreement with results of previous investigations [28,29].…”

Detoxification capacity and protective effects of medicinal plants (part 2): plant based review

“…Saffron at 40 mg/kg/day significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively) [105].…”

The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male wistar rats

“…Moreover an elevation in serum urea and creatinine in a woman following therapeutic dose of paracetamol three days before hospital admission was reported 22 . This elevation in the levels of urea and creatinine was explained by the presence of strong correlation between nephrotoxicity and oxidative stress 23,14 . These biochemical alterations were corroborated by the histological findings of glomerular and tubulo-interstitial necrosis in the untreated model control group (B).…”

“…Animals were randomly assigned into four groups (A-D) of eight rats per group (14). Group (A) animals served as the control group and were treated with normal sa-line (5 ml/kg by gavage daily) throughout the experimental period.…”