Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke

Wolf, Steven L.; Winstein, Carolee J.; Miller, J. Philip; Taub, Edward; Uswatte, Gitendra; Morris, David; Giuliani, Carol; Light, Kathye E.; Nichols-Larsen, Deborah S.

doi:10.1001/jama.296.17.2095

Cited by 1,694 publications

(1,438 citation statements)

References 37 publications

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“…For example, training of the paretic limb alone, as proposed in the Constraint Induced Training methods (1,(47)(48)(49)(50)51) , would decrease the ICI and increase the ICF in the lesioned hemisphere both of which might be beneficial for use dependent plasticity. Compensatory training of the nonparetic arm may be detrimental to lesioned hemisphere plasticity since training of the limb ipsilateral to the lesion would increase ICI and decrease ICF to this hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults

Waller

Forrester

Villagra

et al. 2008

Journal of the Neurological Sciences

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Purpose-To investigate intracortical inhibition and facilitation in response to unilateral dominant, nondominant and bilateral biceps activation and short-term upper extremity training in right and left-handed adults.Methods-Paired-pulse transcranial magnetic stimulation was used to measure intracortical excitability in motor dominant and nondominant cortices of 26 nondisabled adults. Neural facilitation and inhibition were measured in each hemisphere during unilateral dominant, nondominant and bilateral arm activation and after training in each condition.Results-No differences were seen between right and left-handed subjects. Intracortical facilitation and decreased inhibition were seen in each hemisphere with unilateral activation/ training of contralateral muscles and bilateral muscle activation/training. Persistent intracortical inhibition was seen in each hemisphere with ipsilateral muscle activation/training. Inhibition was greater in the nondominant hemisphere during dominant hemisphere activation (dominant arm contraction). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion-Strongly NIH Public Access

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Section: Discussionmentioning

confidence: 99%

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults

Waller

Forrester

Villagra

et al. 2008

Journal of the Neurological Sciences

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“…In patients who have had a stroke, forced use of the affected limb promotes recovery of that limb and remapping of brain activity in periinfarct cortex (32)(33)(34). If the ephrin-A5 system plays a significant role in remapping motor system projections within periinfarct cortex, it is important to test the interaction of ephrin-A5 signaling with forced limb use.…”

Section: Ephrin-a5 Signaling Interacts With Patterned Behavioral Actimentioning

confidence: 99%

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke

Overman¹,

Clarkson

Wanner³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

225

310

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Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 signaling using a unique tissue delivery system induces the formation of a new pattern of axonal projections in motor, premotor, and prefrontal circuits and mediates recovery after stroke in the mouse through these new projections. Combined blockade of ephrin-A5 and forced use of the affected limb promote new and surprisingly widespread axonal projections within the entire cortical hemisphere ipsilateral to the stroke. These data indicate that stroke activates a newly described membrane-bound astrocyte growth inhibitor to limit neuroplasticity, activity-dependent axonal sprouting, and recovery in the adult.cortical map | regeneration | repair | motor function | EphA4

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“…Foram encontrados 352 artigos, dos quais apenas 6 (27)(28)(29)(30)(31)(32) a) há poucos artigos que comparam a TCI com outra técnica de reabilitação; b) dentre os artigos encontrados, com exceção do estudo EXCITE, o número da amostra é pequeno; e c) os artigos somente foram pesquisados em três bases de dados.…”

Section: Resultsunclassified

Terapia por contensão induzida: revisão de ensaios clínicos

2010

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ResumoIntrodução: A Terapia por Contensão Induzida (TCI) é uma terapêutica que visa à recuperação da função do membro superior (MS) parético de pacientes com sequelas de um acidente vascular cerebral por meio de treinamento intensivo, uso de uma restrição no MS não-parético durante 90% do dia e pelo pacote de transferência. Objetivo: O objetivo deste trabalho é realizar uma revisão entre os estudos que compararem a TCI com outras terapêuticas. Metodologia: Foi realizada uma pesquisa nas bases de dados MEDLINE, SciELOo e ISI Web of Science com o descritor "constraint induced movement therapy" durante o mês de junho de 2008. Resultados: Foram encontrados seis artigos onde a TCI foi comparada com os métodos Bobath e Kabat. Discussão: Dentre os artigos encontrados, percebemos que há uma variação entre as amostras de cada estudo, assim como o método de avaliação entre as terapêuticas. Conclusão: A TCI mostrou-se superior em relação às outras terapêuticas. Palavras-chave:

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Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke

Cited by 1,694 publications

References 37 publications

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left- and right-handed adults

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke

Terapia por contensão induzida: revisão de ensaios clínicos

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