Effect of Coating Materials on Lymph Nodes Detection Using Magnetite Nanoparticles

Comparison of estimated human dose of 68Ga-MAA with 99mTc-MAA based on rat data

“…The rats were anesthetized with ketamine 50 mg/kg and xylazine 5 mg/kg; the 68 Ga-MAA was injected into the rats' tail vein [34,35]. Static PET/CT imaging of the first rat was performed 50 min after 7.5 MBq injection of 68 Ga-MAA on the SIEMENS Biograph 6 clinical PET/ CT scanner [36].…”

Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats

“…These contrast agents have variable applications in different medical fields, including cancer imaging [3][4][5], cell tracking [6][7][8], drug delivery [9] lymph node detection [10,11] and therapy [12,13]. Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agents in magnetic resonance imaging (MRI) agent with a abundant potential to detect lymph nodes and related metastases in various cancers [7,10]. SPIONs are fast growing scientific and research field, with a number of products of in terms of size and coating and they are already available commercially.…”

“…Dextran is biocompatible polymer which SPION is being surrounded by it and causes reduction of uptake by the reticuloendothelial systems (RES) and increasing circulation half-life and improvement accumulation in interest tissues [14]. According to research of Oghabian et al dextran-SPION had been applied as contrast-enhanced-MRI for diagnosis of lymph node metastasis in animal study [10]. In parallel with SPION, another nanoparticle of SPION which has 20-40 nm diameters and called ultra-small super paramagnetic iron oxide (USPIO) is able to be coated with dextran.…”

“…In continuation of our recent works on the development of nanoparticles [10,21] and biodistribution studies with radioisotopes [22][23][24], we were interested in development and biodistribution evaluation of 166 Ho-DTPA-SPIONas an dual modality contrast agent in MRI and SPECT and as a theranostic agent for RES-following intravenous (i.v.) administration in normal Wistar rats.…”

Evaluating the effect of ultrasmall superparamagnetic iron oxide nanoparticles for a long-term magnetic cell labeling

“…[3–5] There is an increasing interest in using MRI to observe the in vivo behavior of stem and other cells labeled with ultra small superparamagnetic iron oxide (USPIO) nanoparticles. The USPIO nanoparticles are emerging as an ideal probe for noninvasive cell tracking.…”