Effect of clonidine on stress-induced cortisol release in man during surgery

Masala, A.; Satta, G.; Alagna, S.; Anania, V.; Frassetto, G.; Rovasio, P. P.; Semiani, A.

doi:10.1016/0031-6989(85)90104-3

Cited by 25 publications

(11 citation statements)

References 12 publications

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“…Dorothee et al showed that oral administration of clonidine suppressed the elevation of plasma cortisol concentration during the operation in patients undergoing neurosurgery [5]. Masala et al reported that intravenous drip administration of clonidine suppressed the responses of sympathetic systems and the elevation of plasma cortisol concentration in surgery for chronic sinusitis [6]. However, other studies showed that administration of clonidine depressed the responses of sympathetic systems but could not blunt the elevation of plasma cortisol concentration in pelvic [7] and breast [8] surgery.…”

Section: Discussionmentioning

confidence: 96%

Clonidine premedication prevents sympathetic hyperactivity but does not prevent hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy

Yotsui

2001

Journal of Anesthesia

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Section: Discussionmentioning

confidence: 96%

Clonidine premedication prevents sympathetic hyperactivity but does not prevent hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy

Yotsui

2001

Journal of Anesthesia

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“…A significant decrease in cortisol was recorded after premedication in all groups. Alpha-2 agonists have been known to influence the pituitary response and may decrease adrenocorticotropic hormone output (Masala et al 1985). Various studies have shown that alpha-2 agonists reduce the perioperative levels of stress-related hormones and thus attenuate the stress response to surgery in dogs (Ambrisko & Hikasa 2002).…”

Section: Interpretation Of Biochemical Observationsmentioning

confidence: 99%

Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane-anaesthetised water buffaloes (<i>Bubalus bubalis</i>)

Singh

Kinjavdekar

Amarpal

et al. 2013

J. S. Afr. Vet. Assoc.

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The present study was undertaken to investigate the sedative, analgesic and clinical effects of xylazine, medetomidine and dexmedetomidine with fentanyl as pre-anaesthetics in water buffaloes and to compare the dose-sparing effect of xylazine, medetomidine and dexmedetomidine on thiopental for induction and isoflurane for maintenance of anaesthesia in water buffaloes. Six male water buffaloes randomly received intravenous fentanyl (5.0 µg/kg body weight) and xylazine (0.05 mg/kg body weight), fentanyl (5.0 µg/kg body weight) and medetomidine (2.5 µg/kg body weight), fentanyl (5.0 µg/kg body weight) and dexmedetomidine (5.0 µg/kg body weight) at weekly intervals in groups I1, I2 and I3, respectively. After 15 min, the animals were restrained in right lateral recumbency and anaesthesia was induced by 5% thiopental sodium administered intravenously. The intubated animal was connected to the large animal anaesthesia machine and isoflurane in 100% oxygen (5 L/min) was insufflated for 60 min. The treatments were compared by clinicophysiological, haematobiochemical and haemodynamic parameters. Fentanyl-medetomidine and fentanyl-dexmedetomidine produced more cardiovascular depression during the pre-anaesthetic period but less depression of cardio-respiratory dynamics in the post induction and maintenance period. Quicker recovery was recorded in I2 and I3 groups. A lower dose of thiopental was required in group I3 (4.33 mg/kg ± 0.66 mg/kg) than in groups I2 (4.41 mg/kg ± 0.98 mg/kg) and I1 (4.83 mg/kg ± 0.79 mg/kg). The dose of isoflurane was less in group I3 (45.50 mL ± 5.45 mL) than in group I1 and I2 (48.66 mL ± 5.10 mL and 48.00 mL ± 6.38 mL). Better anaesthesia was recorded with fentanyl-dexmedetomidine-thiopental-isoflurane (group I3) than with fentanyl-medetomidine-thiopental-isoflurane (group I2) and fentanyl-xylazine-thiopental-isoflurane (group I1). Fentanyl-medetomidine and fentanyl-dexmedetomidine were better pre-anaesthetic agents in comparison to fentanyl-xylazine for thiopental and isoflurane anaesthesia. Fentanyl-dexmedetomidine-thiopental-isoflurane and fentanyl-medetomidine-thiopental-isoflurane produced effective surgical anaesthesia and were found to be safe, as cardio-pulmonary functions were well preserved during maintenance anaesthesia with no deleterious effect on vital organ functions in water buffaloes.

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“…Alpha-2 receptor agonists also increase the release of growth hormone [94] and inhibit adipose tissue lipolysis. Clonidine can inhibit the secretion of adrenocorticotropic hormone (ACTH) and cortisol during surgery [95].…”

Section: Neuroendocrine System Effectsmentioning

confidence: 99%

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

Khan¹,

Ferguson²,

Jones³

1999

Anaesthesia

598

423

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SummaryClonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have a role in providing haemodynamic stability in patients who are at risk of peri-operative ischaemia. The side-effects of hypotension and bradycardia have limited the routine use of alpha-2 adrenoceptor agonists. Investigations into the molecular pharmacology of alpha-2 adrenoceptors have elucidated their role in the control of wakefulness, blood pressure and antinociception. We discuss the pharmacology of alpha-2 adrenoceptors and their therapeutic role in this review.

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Effect of clonidine on stress-induced cortisol release in man during surgery

Cited by 25 publications

References 12 publications

Clonidine premedication prevents sympathetic hyperactivity but does not prevent hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy

Clonidine premedication prevents sympathetic hyperactivity but does not prevent hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy

Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane-anaesthetised water buffaloes (<i>Bubalus bubalis</i>)

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

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