Clonidine premedication prevents sympathetic hyperactivity but does not prevent hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy

Abstract

Clonidine premedication prevents sympathetic hyperactivity but does not suppress hypothalamo-pituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy.

Study on Role of Oral Clonidine in Laparoscopic Cholecystectomy Surgery – A Comparative Study

“…Cevheroglu, Ozcan and Bilgin (1999) 6 observed in their study that systolic blood pressure significantly decreases in the preoperative, after induction, during the operation and in postoperative period. Similarly, Yotsui (2001) 9 has observed that systolic blood pressure was lower in the clonidine group than in the placebo control group immediately after endotracheal intubation and extubation, where the control and clonidine groups received placebo on clonidine 4 microg/kg orally 2 hours before the induction of anesthesia, which are almost similar with the present study.…”

Effects of intravenous clonidine on haemodynamics and on plasma cortisol level during laparoscopic cholecystectomies

“…Yotsui stated that considering past studies, administration of clonidine cannot inhibit the responses of the hypothalamic-pituitary-adrenal (HPA) axis to surgical stress, except in minor surgery. [ 10 ] Joris et al . used 8 μg/kg of clonidine, which significantly reduced the concentration of catecholamine but not vasopressin and plasma cortisol concentration.…”

Effect of intravenous clonidine premedication in patients undergoing laparoscopic cholecystectomy

“…They concluded that clonidine premedication prevents sympathetic hyperactivity but does not suppress hypothalamopituitary-adrenocortical responses in patients undergoing laparoscopic cholecystectomy. 18 In our study, increase in mean arterial pressure more than 20% from the baseline at any point intraoperatively, was treated with nitro-glycerine infusion. Sixteen patients (32%) in placebo group received titrated nitro-glycerine infusion (0.5µg/kg/min) intraoperatively, whereas only five patients (10%) of clonidine group showed short duration increase in blood pressure which responded well to single nitro-glycerine bolus.…”