Effects of intravenous clonidine on haemodynamics and on plasma cortisol level during laparoscopic cholecystectomies

Comparison between intravenous and intrathecal clonidine for postoperative analgesia of patients submitted to laparoscopic cholecystectomy: randomized clinical trial

“…In the present study, a decrease in BP and HR values was observed in the clonidine groups in agreement with the studies by Anjum et al, 13 Singh et al, 22 Sahajananda and Rao, 23 and Kamble et al 24 On the other hand, patients of the IVCG and ITCG groups showed similar results for hemodynamic variables, with no superiority of one administration route over the other.…”

“…Patients who received clonidine required less morphine than patients of the control group, and showed reduction in the cumulative dose and less consumption of analgesics in the perioperative period, similar to the results reported by Samantaray et al, 18 Bharti et al, 19 and Ahmed et al 20 According to the systematic review and meta-analysis by Zhang et al, 21 clonidine promoted decrease in opioid requirements intraoperatively, lower nausea and vomiting incidence, less surgical stress response, and hemodynamic stability. 22 , 23 …”

The efficacy of intravenous clonidine premedication to reduce surgical area bleeding in posterior lumbar spine fusion surgery

“…They observed significant incidences of bradycardia and hypotension in their study. Sahajananda & Rao [19] and Samantaray et al [21] studied the effect of intravenous clonidine at 3µg/kg observed no significant events like bradycardia and hypotension requires vasopressor, correlates better with our observation.…”

“…Many previous studies compared the effect of oral clonidine to produce blood less surgical field by its hypotensive action [14][15][16]. But study on intravenous clonidine was few and they analysed the effect of clonidine on reduction of hemodynamic stress response to laryngoscopy, maintaining controlled hypotension, hemodynamic stability intraoperatively, sedation, analgesia and postoperative shivering [17][18][19][20][21][22].…”

Effects of intravenous clonidine on hemodynamics and plasma cortisol level during laparoscopic urological surgeries in a tertiary care hospital

“…Patients were randomized using sealed envelope technique into • Group C-received IV Clonidine 3 mcg/kg in 20 ml normal saline • Group P -received IV 20 ml normal saline only. 9 Patient as well as primary investigator was unaware of the group allocation, group allocation and blinding technique shown in consort diagram (Figure 1).…”