Effect of cinnamon, clove and some of their constituents on the Na+-K+-ATPase activity and alanine absorption in the rat jejunum

Thymol and trans-cinnamaldehyde reduce active nutrient absorption and chloride secretion in the pig jejunal Ussing chamber model

“…Presumably, the effects in our study can be ascribed to a direct inhibitory effect towards the activity of the basolateral Na + -K + -ATPase. This assumption is in agreement with the work of Kreydiyyeh et al (2000), at least in the case of trans-cinnamaldehyde. These authors showed that cinnamaldehyde inhibited the activity of rat intestinal Na + -K + -ATPase in a concentration-dependent manner (IC50; 1.1 mg/mg protein jejunal homogenate).…”

“…5.2 mmol/L) and cinnamaldehyde (app. 7.5 mmol/L) reduced significantly the L-alanine absorption, which was attributed to the inhibition of basolateral Na + -K + -ATPase activity (Kreydiyyeh et al, 2000). In the pig Ussing chamber model, Boudry and Perrier (2008) found a dosedependent (0-0.1 mmol/L) increase in Isc (anion secretion) after addition of thymol and cinnamaldehyde.…”

Essential Oils as a Feed Additive in Poultry Nutrition

“…reported that cinnamaldehyde in diet had a role in the digestion process while thymol is not involved in these processes. Kreydiyyeh et al (2000) observed that there was an increase in the absorption of glucose in the intestine of rats when they were fed with anise oil.…”

Cinnamon and Health

“…Over the past several years, the effectiveness of cinnamon supplementation for the management of diabetes has received worldwide media attention. Several in vitro (Anderson et al, 2004;Berrio et al, 1992;Broadhurst et al, 2000;Cao et al, 2007; Downloaded by [University of Saskatchewan Library] at 21:27 06 October 2012 Imparl-Radosevich et al, 1998;Jarvill-Taylor et al, 2001;Khan et al, 1990;Kim et al, 2006b;Kreydiyyeh et al, 2000;Lee, 2002;Roffey et al, 2006;Taher et al, 2004;Talpur et al, 2005) and in vivo studies (Kannappan et al, 2006;Kim et al, 2006a;2006b;Onderoglu et al, 1999;Qin et al, 2003;Subash Babu et al, 2007;Verspohl et al, 2005) on the effects of cinnamon on insulin resistance and glucose metabolism have been published. Clinical trials investigating the effects of cinnamon in healthy subjects (Hlebowitz et al, 2007;Solomon and Blannin, 2007) as well as the efficacy of cinnamon in the treatment of diabetes mellitus type 1 and 2 (Altschuler et al, 2007;Blevins et al, 2007;Khan et al, 2003;Mang et al, 2006;Suppapitiporn et al, 2006;Vanschoonbeek et al, 2006) or insulin resistance (Wang et al, 2007) have also been published (see below).…”