Effect of Cimetidine on Nitro-Oxidative Stress in a Rat Model of Periodontitis

Culic, Carina; Pârvu, Alina Elena; Alb, Sandu Florin; Alb, Camelia; Pop, Angela

doi:10.15386/cjmed-273

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…The clinical and histopathological features described in our experimental rat periodontitis were consistent, in evolution, with the specific aspects reported in human chronic periodontitis [ 33 , 34 ]. On the other hand, our findings regarding the association between periodontitis and the high levels of NOx, TOS and OSI were similar to other experimental and clinical studies [ 27 , 28 , 35 , 36 ]…”

Section: Discussionsupporting

confidence: 92%

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Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis

Boşca

Mitre

Ilea

et al. 2016

Medicine and Pharmacy Reports

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Background and aimsPeriodontitis is a common chronic adult condition that implicates oxidative damage to gingival tissue, periodontal ligament and alveolar bone. This study aimed at assessing the association between the nitro-oxidative stress and the periodontal tissues destructions in experimental rat periodontitis.MethodsPeriodontitis was induced in 15 male albino rats by repetitive lesions to the gingiva adjacent to the inferior incisors, performed daily, for 16 days. On D1, D3, D6, D8, and D16 the onset and evolution of periodontitis were monitored by clinical and histopathological examinations; blood was collected and serum nitro-oxidative stress was evaluated through total nitrites and nitrates, total oxidative status, total antioxidant capacity, and oxidative stress index.ResultsThe results demonstrated that there was a graded and continuous increase in serum levels of total nitrites and nitrates, total oxidative status and oxidative stress index, which was consistent with the severity of periodontal destructions during periodontitis progression. However, total antioxidant capacity was not significantly influenced by the disease progression.ConclusionsIn experimental rat periodontitis, the systemic nitro-oxidative stress was associated with the severity of periodontal destructions assessed clinically and histopathologically. Therefore, systemic nitro-oxidative stress parameters might be used as diagnostic tools in periodontitis.

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Section: Discussionsupporting

confidence: 92%

“…Our study was the first to assess the nitro-oxidative stress parameters as indicators of the progression and severity of periodontal destructions in experimental rat periodontitis. Previous studies evaluated the injury only at the end of the experiment [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis

Boşca

Mitre

Ilea

et al. 2016

Medicine and Pharmacy Reports

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“…The oxidative damage to the heart, but also endothelial dysfunction and resulting atherosclerosis induced by experimental periodontitis can be prevented by antioxidant treatment (Ekuni et al, 2009 ; Ozdem et al, 2017 ; Saito et al, 2017 ). A majority of the published experiments focus on the use of antioxidants such as vitamin C (Tomofuji et al, 2009b ), N-acetylcysteine (Toker et al, 2009 ), or resveratrol (Tamaki et al, 2014a ), but also drugs with an antioxidant activity beyond their main mechanism of action (de Araujo Junior et al, 2013 ; Culic et al, 2014 ; Oktay et al, 2015 ). Dietary interventions have also been investigated—high cholesterol diet seems to worsen periodontitis (Tomofuji et al, 2006 ).…”

Section: Animal Experimentsmentioning

confidence: 99%

Oxidative Stress and Antioxidants in the Diagnosis and Therapy of Periodontitis

2017

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Oxidative stress has been implicated in the pathogenesis of numerous diseases. However, large interventional studies with antioxidants failed to show benefits in the prevention or treatment of cardiovascular diseases, cancer, or diabetes mellitus. Numerous clinical studies have confirmed the association of oxidative stress markers and periodontitis. Technical and biological variability is high for most of the analyzed markers and none of them seems to be optimal for routine clinical use. In a research setting, analysis of a palette of oxidative stress markers is needed to cover lipid peroxidation, protein oxidation, and the antioxidant status. The source of reactive oxygen species and their role in the pathogenesis of periodontitis remains unclear. Interventional experiments indicate that oxidative stress might be more than just a simple consequence of the inflammation. Small studies have confirmed that some antioxidants could have therapeutic value at least as an addition to the standard non-surgical treatment of periodontitis. A clear evidence for the efficiency of antioxidant treatment in large patient cohorts is lacking. Potentially, because lowering of oxidative stress markers might be a secondary effect of anti-inflammatory or antibacterial agents. As the field of research of oxidative stress in periodontitis gains attraction and the number of relevant published papers is increasing a systematic overview of the conducted observational and interventional studies is needed. This review summarizes the currently available literature linking oxidative stress and periodontitis and points toward the potential of adjuvant antioxidant treatment, especially in cases where standard treatment fails to improve the periodontal status.

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“…17 Regarding the analgesic effect of cimetidine, recent reports indicated an anti-inflammatory mechanism of cimetidine in animal models. Culic et al showed that low-dose cimetidine had anti-inflammatory activity by reducing nitro-oxidative stress in a rat model of periodontitis, 18 and Aparecida et al reported that cimetidine reduced the immunoexpression of interleukin-6 and matrix metalloproteinases-1 and -9 in rats with induced periodontal disease. 19 Yokoyama et al reported that cimetidine was effective for the treatment of chronic calcific periarthritis of the shoulder.…”

Section: Discussionmentioning

confidence: 99%

Chronic calcific periarthritis of the elbow treated by cimetidine administration: Five cases

Kimura

Iwamoto

Oki

et al. 2017

J Orthop Surg (Hong Kong)

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Calcific periarthritis or calcific tendinitis occurs most frequently in the shoulder and rarely in the elbow. Cimetidine was previously reported to be effective for chronic calcific periarthritis of the shoulder. Here, we present five patients with chronic calcific periarthritis of the elbow treated by administration of cimetidine; there were six affected elbows in these five patients. Although all patients had been treated with nonsteroidal anti-inflammatory drugs for at least 3 months, their symptoms were not relieved. All patients took oral administration of cimetidine 400 mg daily. The pain was completely relieved in an average of 1.8 months after the administration of cimetidine, and the calcification of the elbow disappeared in an average of 5.1 months. During the follow-up period, there were no symptoms suggesting a recurrence. Although the detailed mechanism of action of cimetidine on periarticular calcifications remains to be understood, cimetidine appears to be a potential therapeutic agent for chronic calcific periarthritis.

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Effect of Cimetidine on Nitro-Oxidative Stress in a Rat Model of Periodontitis

Cited by 3 publications

References 28 publications

Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis

Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis

Oxidative Stress and Antioxidants in the Diagnosis and Therapy of Periodontitis

Chronic calcific periarthritis of the elbow treated by cimetidine administration: Five cases

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