Effect of Chronic Administration of Morphine on the Gene Expression Level of Sodium-Dependent Vitamin C Transporters in Rat Hippocampus and Lumbar Spinal Cord
Abstract:Chronic morphine leads to dependence, tolerance, and neural apoptosis. Vitamin C inhibits the withdrawal syndrome in morphine-dependent subjects and prevents apoptosis in experimental models. Sodium-dependent vitamin C transporter (SVCT) type-2 is the main transporter for carrying vitamin C into the brain and neural cells. The mechanism(s) by which vitamin C inhibits morphine dependence in not understood. SVCT activity determines the vitamin C availably within the nervous system. We have examined the alteratio… Show more
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