Effect of chinese softshell turtle egg powder on immune functions in mice

Wang, Junbo; Huan-ling, YU; Shen, Xiaoyi; Zhu, Liangru; Shu, Yan; Kodama, Nenkei; Aoki, Hideo; Li, Yong

doi:10.1080/09540100400014557

Cited by 5 publications

(1 citation statement)

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“…IPP treatment also stimulated NK cell activity in mice. NK cells play an important role in serving as the first line of defense against microbial infections as well as providing surveillance on neoplastic cells [17]. In this connection, the stimulation of NK cell activity by IPP treatment was associated with the suppression of tumor growth in Sarcoma 180 cellinoculated mice.…”

Section: Discussionmentioning

confidence: 98%

Long-Term Treatment with a Compound Polysaccharide-Based Health Product (Infinitus Polysac Plus) Enhances Innate and Adaptive Immunity in Mice

Leung¹,

Ma²,

Tang³

et al. 2011

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This study aimed to investigate the effects of a compound polysaccharide-based health product (Infinitus Polysac Plus, IPP) on innate and adaptive immunity in mice. Both ex vivo/in vivo mouse models and an in vitro system using cultured mouse splenocytes were adopted for the assessment of innate and adaptive immunity. For the innate immune response, long-term IPP treatment (0.26 and 0.78 g/kg * 20 doses) enhanced the carbon clearance activity and phagocytic rate of macrophages, as well as natural killer cell activity in mice. The IPP-induced increase in natural killer cell activity was accompanied by the suppression of tumor growth in Sarcoma-180 cell-inoculated mice. For the adaptive immune response, while long-term IPP treatment increased the splenocyte index in mice, IPP incubation with mouse splenocytes in vitro potentiated their concanavalin A-stimulated proliferation. Long-term IPP treatment significantly restored the hemolytic activity of serum on sheep red blood cells and dinitrofluorobenezene-induced delayed-type hypersensitivity in sensitized and immunosuppressed mice. In conclusion, the results indicate that long-term IPP treatment produces stimulatory effects on both innate and adaptive immunity in mice

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Section: Discussionmentioning

confidence: 98%