Protective effect of a marine oligopeptide preparation from Chum Salmon (<i>Oncorhynchus keta</i>) on radiation‐induced immune suppression in mice

Yang, Ruiyue; Pei, Xinrong; Wang, Junbo; Zhang, Zhaofeng; Zhao, Haifeng; Li, Qiong; Zhao, Ming; Li, Yong

doi:10.1002/jsfa.4077

Cited by 33 publications

(16 citation statements)

References 31 publications

(34 reference statements)

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“…MOP groups, the white cell counts were not significantly augment compared with the IR control group, although slight increases were observed. These results are consistent with our other data [13] in that WBI of mice do cause an exponential decline in cell survival of splenic cells and a depression capable of the response of splenic mononuclear cells to mitogens, both concanavalin A and lipopolysaccharide, and MOP can alleviate these inhibition effects. Considering these findings, we conclude that MOP possesses good irradiation protection property, which partly attributes to their strong immunostimulative activity.…”

Section: Resultssupporting

confidence: 93%

“…MOP caused a decline of 18% in the apoptosis rate of splenocytes ( P < 0.05). The result was similar to the findings of our other studies [13] in that MOP treated group significantly impaired the radiation-induced changes of levels of apoptosis-related proteins. Taken together, these results demonstrate that treatment with MOP protects the mitochondrial membrane against radiation-induced immune cell damage and genetic damage.…”

Section: Resultssupporting

confidence: 92%

“…Our earlier research demonstrated that marine oligopeptide preparation (MOP), compounds of low molecule peptides extracted from salmon minced meat by enzymatic hydrolysis, possess a radioprotective property through stimulation of the radiation-induced immunosuppression, and may have a supplementary protective effect in cancer therapy [13]. The present study reported here mainly focuses on the free radicals scavenging and antioxidant effects of MOP in radiation injured mice.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice

et al. 2011

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Marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to possess a radioprotective property through stimulation of the radiation-induced immunosuppression. The current study aimed to further investigate the free radicals scavenging and antioxidant effects of MOP in radiation injured mice. Female ICR mice (6–8 weeks old) were randomly divided into 5 groups, i.e., blank control, irradiation control and MOP (0.225, 0.450 and 1.350 g/kg body weight) plus an irradiation-treated group. The result revealed that MOP significantly increased the white blood cell counts after irradiation, and lessened the radiation-induced oxidative damage. These effects may be caused by augmentation of the activities of antioxidant enzymes, such as SOD and GSH-Px, reduction of the lipid peroxidation (MDA level) in liver, and protection against radiation-induced apoptosis. Therefore, we propose that MOP be used as an ideal antioxidant to alleviate radiation-induced oxidation damage in cancer patients.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice

et al. 2011

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“…Our studies and those of others revealed atrophy of the hematopoietic tissues, a decrease in WBC counts, and immune dysfunction in fish and mammals during the first few days after radiation [5, 14, 15, 33–35]. In this study, fish exposed to γ-radiation for 1 week showed a significant decrease in the total number of WBCs.…”

Section: Discussionsupporting

confidence: 75%

Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in γ-radiated Nile tilapia, Oreochromis niloticus

Ghoneum

Elbaghdady

El-Shebly

et al. 2013

Journal of Radiation Research

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Hydroferrate fluid, MRN-100, an iron-based compound derived from bivalent and trivalent ferrates, is a potent antioxidant compound. Therefore, we examined the protective effect of MRN-100 against γ-radiation-induced lethality and damage to hematopoietic tissues in fish. A total of 216 Nile tilapia fish (Oreochromis niloticus) were randomly divided into four groups. Group 1 served as a control that was administered no radiation and no MRN-100 treatment. Group 2 was exposed only to γ-radiation (15 Gy). Groups 3 and 4 were pre-treated with MRN-100 at doses of either 1 ml/l or 3 ml/l in water for 1 week, and subsequently exposed to radiation while continuing to receive MRN-100 for 27 days. The survival rate was measured, and biochemical and histopathological analyses of hematopoietic tissues were performed for the different treatment groups at 1 and 4 weeks post-radiation. Exposure to radiation reduced the survival rate to 27.7%, while treatment with MRN-100 maintained the survival rate at 87.2%. In addition, fish exposed to γ-radiation for 1 week showed a significant decrease in the total number of white blood cells (WBCs) and red blood cells (RBCs) series. However, treatment with MRN-100 protected the total WBC count and the RBCs series when compared with irradiated fish. Furthermore, significant histological lesions were observed in the hepatopancreas, spleen and gills of irradiated fish. However, treatment with MRN-100 protected the histopathology of various organs. We conclude that MRN-100 is a radioprotective agent in fish and may be useful as an adjuvant treatment to counteract the adverse side effects associated with radiation exposure.

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“…Radiation is an important environmental factor with hazardous effects on health, including oxidative stress [1,2], hematopoietic system dysfunction [3], genetic mutations [4] and immune dysfunction [5]. Ionizing radiation (IR) administered during radiotherapy generates free radicals when it passes through living tissues.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling

Guida

El-Aal

Kafafy

et al. 2016

Cell Physiol Biochem

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Background/Aims: Recent studies have shown that thymoquinone (TQ) exerts protective effects against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats. Nevertheless, there is no published work investigated the effects of TQ on T cell development and biology in animal models exposed to gamma radiation. Therefore, in the present study we focused on determining the effects of TQ on radiation damage in the thymus, radiation-induced T cell imbalance, and on immune dysfunction induced by gamma-rays. Methods: Three groups of rats were used: a control group, a gamma-irradiated group, and a gamma-irradiated group that was orally supplemented with TQ. Serum lipid profiles, malondialdehyde (MDA) levels, and pro-inflammatory cytokine levels were measured to assess gamma irradiation-induced oxidative stress and inflammatory capacity. T cell apoptosis was evaluated by annexin V/propidium iodide staining followed by flow cytometry analysis. The expression of pro-apoptotic proteins such as Bax and caspase-3, the anti-apoptotic protein Bcl-2, and an exhaustion marker of T cells (PD-1) in CD4⁺ and CD8⁺ T cell populations was evaluated using flow cytometry analysis. The T cell architecture of the thymus gland was evaluated by histological analysis. Results: Exposure to gamma radiation increased triglyceride, cholesterol, LDL-C, MDA, TNF-α and IL-6 levels and decreased HDL-C levels. The altered lipid profile and MDA and pro-inflammatory cytokine (TNF-α and IL-6) levels induced by exposure to gamma radiation were significantly restored in TQ-treated gamma-irradiated rats. Rats exposed to gamma radiation exhibited increased exhaustion of T lymphocytes via down-regulation of Bcl-2 expression and upregulation of PD-1, Bax, and caspase-3 expression, which sensitized these cells to apoptosis. Interestingly, treatment of gamma-irradiated rats with TQ decreased T cell exhaustion and apoptosis by modulating the expression of Bcl-2, PD-1, Bax, and caspase-3. Conclusions: Our results provide evidence for the beneficial effects of TQ as an effective radioprotective candidate that enhances cellular immunity.

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Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation‐induced immune suppression in mice

Abstract: We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation-induced injuries in cancer patients.

Cited by 33 publications

References 31 publications

Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice

Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice

Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in γ-radiated Nile tilapia, Oreochromis niloticus

Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling

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