Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice

Yang, Ruiyue; Zhang, Zhaofeng; Pei, Xinrong; Han, Xiaolong; Wang, Junbo; Wang, Linlin; Zhu, Liangru; Shen, Xiaoyi; Li, Yong

doi:10.1016/j.foodchem.2008.07.086

Cited by 133 publications

(105 citation statements)

References 27 publications

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“…The assay was assessed following the method previously described [13]. In brief, 4 days after irradiation, splenocytes were dissociated from the connective tissue capsule and the suspension collected.…”

Section: Lymphocyte Proliferation Assaymentioning

confidence: 99%

“…A bead-based multiplexed assay [13,16] was used to measure IL-1α, IL-2, IL-4, IL-5, IL-6, IL-10, IL-17, IFN-γ, TNF-α and GM-CSF in serum. This assay used microspheres as the solid support for immunoassays and allowed the simultaneous quantification of several cytokines in a small sample volume.…”

Section: Bead-based Multiplexed Assaymentioning

confidence: 99%

“…Previous research on immunological substances usually tested cytokines in serum of mice by using ELISA, but limited sample volumes have restricted analyses to only a few cytokines [13]. In the present study, bead-based multiplex technology was used; this offers the advantages of requiring much smaller sample volumes, having higher precision, being more rapid and cost-effective, and having the possibility of measuring numerous other parameters in parallel [17].…”

Section: Effect Of Cs-ps On Cytokine Levels In Serummentioning

confidence: 99%

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Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co

Zhang

et al. 2011

International Immunopharmacology

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Section: Lymphocyte Proliferation Assaymentioning

confidence: 99%

Section: Bead-based Multiplexed Assaymentioning

confidence: 99%

Section: Effect Of Cs-ps On Cytokine Levels In Serummentioning

confidence: 99%

See 1 more Smart Citation

Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co

Zhang

et al. 2011

International Immunopharmacology

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“…T lymphocyte sub-populations T lymphocyte subpopulations in the spleen of control-and adaptogen-treated mice were measured using flow cytometer (Yang et al, 2009). Mice were sacrificed 24 h after the last dose of MP.…”

Section: Cytokinesmentioning

confidence: 99%

Mineral pitch stimulates humoral, cellular and innate immune responses in mice

Rubab

Routray

Mahmood

et al. 2013

Pharmaceutical Biology

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Context: Mineral pitch (MP), a traditional medicine, is proposed to boost immunity in conditions that suppress Th1 cytokines such as AIDS/HIV, tuberculosis, leishmaniasis and cancer. Objective: This study investigates the immunoregulatory mechanisms of MP in innate, humoral and cell-mediated immunity. Materials and methods: Mice given MP (100, 200, 300 or 400 mg/kg, orally) for 10 consecutive days were immunized intravenously with goat RBC or ovalbumin, and investigated for plaqueforming cells (PFC), hemagglutination titer, hypersensitivity response, lymphocyte proliferation and macrophage function. Results: MP increased PFC (330.2 versus 182.2/10 6 splenocytes) in mice immunized with goat RBC and elicited ovalbumin-specific IgG titer at 400 mg/kg. Increase in Th1 immunity was correlated with the increased level of IFN-g (724 versus 470 pg/ml) and decreased IL-4 (96 versus 178 pg/ml). CD4 þ /CD3þ ratio and delayed-type hypersensitivity response also increased to, respectively, 20.62 AE 0.59 (versus 16.47 AE 0.72) and 1.59 AE 0.12 (versus 0.87 AE 0.10 mm) in MP-treated mice. MP increased lymphocyte proliferation (11.14 AE 0.60 versus 5.81 AE 0.40 SI) and macrophage phagocyte response (0.24 AE 0.02 versus 0.15 AE 0.009), expressed as absorbance at 570 nm, but decreased nitrite production (17.4 AE 1.10 versus 24.3 AE 1.30 mM/10 6 cells). We also observed an increased bone marrow cellularity (24.5 AE 1.10 versus 17.10 AE 0.70 cells/femur) and WBC count (12 667 AE 377 versus 9178 AE 213 cells/mm 3 ) following MP treatment. There was no sign of toxicity at 400 mg/kg, 1/12th of reported LD 50 . Conclusion: MP elicits a dose-dependent Th1 immune response.

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“…In particular, several marine bioactive compounds are under study for their potential antitumor effect (6)(7)(8)(9). Although the detailed mechanisms involved are still a matter of study, antioxidative and antimutagenic properties have been advocated for (10)(11)(12). We have recently shown that Celergen, a popular GMP-controlled marine bioceutical, could significantly inhibit ultraviolet (UV)-induced matrix-metalloproteinases (MMP) transcription and exert an antioxidant effect protecting skin fibroblasts (13).…”

Section: Introductionmentioning

confidence: 99%

Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis

Catanzaro¹,

Zerbinati²,

Solimene

et al. 2013

Drug Discov Ther

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The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21 CIPl1WAF1 , GADD153 genes and downregulated the c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.

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Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice

Cited by 133 publications

References 27 publications

Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co

Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co

Mineral pitch stimulates humoral, cellular and innate immune responses in mice

Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis

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