Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension

Zhong, Guangwei; Min-jing, Chen; Luo, Yanhong; Xiang, Ling-Li; Xie, Qiang-min; Li, Yunhui; Zhang, Chen; Gao, Feng

doi:10.1007/s11655-011-0761-6

Cited by 19 publications

(20 citation statements)

References 7 publications

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“…The first, a study by Zhong et al ., assessed the efficacy of a TCM decoction for calming Gan and suppressing hyperactive yang (GSHY) compared with enalapril. There were no significant differences in ABPM parameters between the two groups, the TCM decoction demonstrating a similar antihypertensive effect to enalapril in this setting . The second study comprised three groups of elderly patients with isolated systolic hypertension: one taking both TCM (Jiangya capsule) and PM (nimodipine tablet), one taking TCM and a simulated PM tablet, and one taking PM and a simulated TCM capsule .…”

Section: Resultsmentioning

confidence: 92%

Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Layne

Ferro

2016

Brit J Clinical Pharma

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AIMSThe aim was to perform a systematic review of the efficacy of traditional Chinese medicines (TCM) in cardiovascular disease. METHODSElectronic databases were searched up to 11 November 2015 for all randomized-controlled trials evaluating the effect of TCM in hypertension, ischaemic stroke, heart failure, coronary heart disease and type 2 diabetes mellitus. Pooled odds ratios (ORs) were calculated using a fixed-effects model. RESULTSFour hypertension studies were eligible for statistical analysis and included 133 patients receiving TCM and 130 control patients. There were significant reductions in systolic blood pressure in patients receiving TCM, comparable to results achieved with pharmaceutical medicines. An OR of 3.781 (95% confidence interval 2.392, 5.977; P = 0.000) was observed for the antihypertensive effect of TCM. Significant heterogeneity was present (P = 0.011), with a tendency towards publication bias that did not reach significance (P = 0.05275). Outcome measures for other cardiovascular diseases were inconsistent. CONCLUSIONSCertain TCM compounds appear to have significant anti-hypertensive effects, and although some are associated in some studies with improved outcomes in coronary heart disease, heart failure and type 2 diabetes mellitus, the data are inconsistent and will require large-scale randomized-controlled trials to allow full evaluation of any potential therapeutic benefit in these areas.

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Section: Resultsmentioning

confidence: 92%

Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Layne

Ferro

2016

Brit J Clinical Pharma

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“…As compared with TCM syndrome criteria or BP criteria alone, hypertension could be diagnosed more accurately by using the combination of TCM syndrome and BP. When referring to Chinese medicine treatment alone based on diagnosis of disease-syndrome combination, Zhong et al [37] conducted a randomized controlled trial to observe the effect of Chinese herbal medicine for calming Gan and suppressing hyperactive yang (CGSHY) on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension (EH). The authors studied 64 patients comparing Chinese herbal medicine with enalapril to a control.…”

Section: Disease-syndrome Combination Is a New Mode For Treatment mentioning

confidence: 99%

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Xiong

Yang

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine.

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“…13, 14 Moreover, the efficacy of TCM for treating hypertension is demonstrated by numerous published cases and randomized trials. 15, 16, 17 However, some trials have found null results. 18, 19, 20, 21 Numerous randomized controlled trials have been conducted in China to evaluate the efficacy of novel Chinese herbal formulas generated from well-known Chinese medicine formulas or from currently effective practices to treat hypertension.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science

et al. 2013

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Hypertension, which directly threatens quality of life, is a major contributor to cardiovascular and cerebrovascular events. Over the past two decades, domestic and foreign scholars have agreed upon various standards in the treatment of hypertension, and considerable progress has been made in the field of antihypertensive drugs. Oral antihypertensive drugs represent a milestone in hypertension therapy. However, the blood pressure standard for patients with hypertension is far from satisfactory. The study of Chinese herbal formulas for treating hypertension has received much research attention. These studies seek to integrate traditional and Western medicine in China. Currently, Chinese herbal formulas are known to have an outstanding advantage with regard to bodily regulation. Research shows that Chinese medicine has many protective mechanisms. This paper addresses the process of the antihypertensive mechanisms in Chinese herbal formulas for treating hypertension. These mechanisms are to be discussed in future research.

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Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension

Cited by 19 publications

References 7 publications

Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science

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