Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Layne, Kerry; Ferro, Albert

doi:10.1111/bcp.13013

Cited by 38 publications

(28 citation statements)

References 62 publications

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“…Because HF is an eventual syndrome triggered by a variety of factors, such as ventricular dysfunction, volume overload, or pressure overload, and because HF is a significant source of mortality in patients (3), safe and effective treatment is the key to improving quality of life for HF patients. Chinese herbs-traditional medicine used in Asian countries for many years-are demonstrating advantages in safety and efficacy in the management of HF (11)(12)(13)(14)(15). The YXS used in this study contains 7 types of herbs, including radix ginseng, radix ophiopogonis, fructus Schisandrae chinensis, Salvia miltiorrhiza, Astragalus membranaceus, Ligusticum wallichii, and fructus crataegi, which all can be safely used in both food and medicine.…”

Section: Discussionmentioning

confidence: 99%

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Signature‐oriented investigation of the efficacy of multicomponent drugs against heart failure

et al. 2018

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Increasing attention has been paid to the application of precision medicine in heart failure (HF), and biomarker-based personalized medical care has shown great progress in HF management. Additionally, multicomponent drugs represented by traditional Chinese medicine (TCM) are demonstrating safety and efficacy in the management of HF. However, the potential mechanism is unclear, and the ambiguous clinical locations of TCM remain a hindrance to its extensive application. To meet this requirement, a precise investigation on the efficacy of multicomponent drugs against HF using the signature biomarkers-oriented approach was developed and applied to a conventional drug for cardiac disease, YiXinShu (YXS). On the basis of in vitro and in vivo efficacy evaluation of YXS against HF, and with the aid of proteomics and network pharmacology approaches, specific signatures regulated by YXS against HF were identified. YXS may show distinctive treatment features for those HF patients showing the elevation of fatty acid-binding protein 3 and cytoskeleton-associated protein 5, as well as other classic HF biomarkers. This study provides the first precise investigation of the efficacy of multicomponent drugs against HF and offers a practicable and low-cost approach for personalized management of HF.-Wei, J., Guo, F., Zhang, M., Xian, M., Wang, T., Gao, J., Wu, H., Song, L., Zhang, Y., Li, D., Yang, H., Huang, L. Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure.

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Section: Discussionmentioning

confidence: 99%

“…The potential mechanism and ambiguous clinical locations hinder the widespread use of TCM. Therefore, more randomized controlled trials have been performed to systematically review the efficacy of TCM in the management of HF and to try to reveal its precise localization in the clinic (14)(15)(16)(17).…”

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confidence: 99%

Signature‐oriented investigation of the efficacy of multicomponent drugs against heart failure

et al. 2018

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“…To provide high quality of evidence for clinical practice, well-designed, large-scale, multicenter RCTs are recommended (65,66). Definitively, RCTs are necessary to provide evidence for the average efficacy of dispensing granules comparing with traditional decoction.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of dispensing granules with traditional decoction: a systematic review and meta-analysis

et al. 2018

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as effective as the traditional decoction kept unclear. This systematic review and meta-analysis was made to assess the efficacy of dispensing granules compared with traditional decoction. Methods:We searched four databases since their inception to 9th September in 2016. Two authors independently identified trials, extracted data and assessed risk of bias with Cochrane Reviewer's Handbook 5.0. We conducted meta-analysis with RevMan 5.1.0 software for eligible and appropriate trials.Results: In the end, 7,035 participants from 51 randomized controlled trials (RCTs) which compared dispensing granules with traditional decoction were included in this systematic review. There were 33 different kinds of diseases for investigation, of which 8 RCTs observed common cold, 4 RCTs observed migraine. For rheumatoid arthritis, insomnia and hypertension, there were 3 RCTs reported respectively.The last RCTs reported different kinds of diseases in one or two trials. The majority of trials were in low methodological quality. Thirty-eight (74.5%) RCTs showed that the efficacy of dispensing granules were similar with traditional decoction, 6 (11.8%) RCTs reported that the therapeutic efficacy of dispensing granules were significantly better than traditional decoction. We conducted meta-analysis for 4 trials investigating patients with migraine. The results showed that dispensing granules reduced headache frequency by about 1.03 attacks per month as compared to traditional decoction. No evidence was found in terms of migraine intensity and duration. Conclusions:The low quality of RCTs and conflicting results made it difficult to draw a definite conclusion. In the future, it needs much more evidence to explore the efficacy and safety of dispensing granules. N-of-1 trials and fuzzy comprehensive evaluation methods may be better choices for assessing the efficacy of them than RCTs.

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“…Developed in ancient China, Traditional Chinese Medicine provides comprehensive holistic therapies and has been con rmed useful in the prevention and therapy of most pathologies worldwide (11).…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Panax Notoginseng Saponins in Hydrocortisone-Induced Injury in HBMECs by Promoting APOA1 Expression

Jin

Yan

Song

et al. 2020

Preprint

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Background To evaluate the protective effect and underlying mechanism of panax notoginseng saponins (PNS) on hydrocortisone (HC)-induced injury in human bone microvascular endothelial cells (HBMECs).HBMECs were isolated from femoral heads resected in total hip arthroplasty and identified by morphology and immunofluorescence. Methods HBMECs were injured by hydrocortisone (HC), treated with PNS in different concentrations, and transfected with APOA1 or siAPOA1 to explore the role of APOA1 in the process where PNS protected HC-injured HBMECs. The viability and apoptotic rate were determined by CCK-8 and flow cytometry assays, respectively. The migration and tube length of HBMECs were evaluated by wound healing and tube formation assays, respectively. The mRNA expression of APOA1 was determined by qRT-PCR. The proteins levels of APOA1, Bcl-2, Bax and Caspase-3 were determined by Western blot. Results HBMECs exhibited spindle-shaped morphology. CD31 and vWF served as positive control and CD133 served as negative control. The viability of HBMCS inhibited by HC was balanced with the lower mRNA expression of APOA1 in a dose-dependent manner. PNS reversed the inhibitory effect of HC on the mRNA expression of APOP1, cell viability, migration, tube length, and the stimulative effect of HC on apoptosis of HBMECs. APOA1 overexpression further promoted the protective effect of PNS on HC-inhibited cell viability, migration and tube length, and HC-promoted apoptosis, whereas APOA1 silencing inhibited the protective effect of PNS and further promoted the adverse effect of HC on HBMECs. Conclusion PNS can efficiently suppress HC-induced injury in HBMECs, which may be associated with over-expressed APOA1.

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Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review

Cited by 38 publications

References 62 publications

Signature‐oriented investigation of the efficacy of multicomponent drugs against heart failure

Signature‐oriented investigation of the efficacy of multicomponent drugs against heart failure

Comparison of the efficacy of dispensing granules with traditional decoction: a systematic review and meta-analysis

Protective Role of Panax Notoginseng Saponins in Hydrocortisone-Induced Injury in HBMECs by Promoting APOA1 Expression

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