Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science

Abstract

Hypertension, which directly threatens quality of life, is a major contributor to cardiovascular and cerebrovascular events. Over the past two decades, domestic and foreign scholars have agreed upon various standards in the treatment of hypertension, and considerable progress has been made in the field of antihypertensive drugs. Oral antihypertensive drugs represent a milestone in hypertension therapy. However, the blood pressure standard for patients with hypertension is far from satisfactory. The study of Chinese herbal formulas for treating hypertension has received much research attention. These studies seek to integrate traditional and Western medicine in China. Currently, Chinese herbal formulas are known to have an outstanding advantage with regard to bodily regulation. Research shows that Chinese medicine has many protective mechanisms. This paper addresses the process of the antihypertensive mechanisms in Chinese herbal formulas for treating hypertension. These mechanisms are to be discussed in future research.

Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

“…In addition, we recently reported that BOF exerted a favorable effect on metabolism, including an antihypertensive effect, not only via its beneficial effect on adipose tissue function, but also its appetite inhibitory effect in a mouse model of human metabolic disorders with obesity [7]. The development of highly efficient antihypertensive drugs with fewer adverse effects based on oriental herbal medicine is an attractive research subject, and randomized controlled trials are needed to reasonably evaluate the efficacy and safety of oriental herbal medicine for treating hypertension [8]. However, there have been no randomized clinical trials investigating possible effects of BOF on blood pressure (BP) profiles in hypertensive patients with obesity.…”

Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials

“…All these symptoms are not only the basis of syndrome differential diagnosis but also the therapeutic targets of CHM. 38,39 Several cross-sectional studies found that symptoms have a significant negative impact on the overall HRQOL. 40,41 In this systematic review, seven of the included trials also showed that CHM has positive effects for relieving symptoms related to hypertension.…”

Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3ζ downregulation

“…Increasing evidences have indicated that traditional Chinese medicine could be effective in treatment of a variety of diseases, such as hypertension [9], chronic kidney disease [10] and endometriosis [11]; it thus might also be a good therapeutic option for adenomyosis. On the other hand, multiple studies have suggested that endometrial stromal cells (ESCs) in adenomyosis might play crucial roles in the initiation and progression of this disease, emphasizing the importance of targeting ESCs in the treatment of adenomyosis [12][13][14].…”