Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

Abstract

UMIN000003878.

Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice

“…Thus, BTS specifically reduced whole-body weight by suppressing the increase in white adipose tissue weight resulting from a high-fat diet. This result parallels observations in obese humans, although the chosen doses of BTS were greater than the human clinical dose (0.095 g/kg) [25]. …”

“…Noradrenaline induces thermogenesis in brown adipose tissue via β 3 -adrenergic receptor and lipolysis in white adipose tissue through increased cyclic AMP synthesis. Glycyrrhiza, Forsythia, and Schizonepeta have potent inhibitory effects on phosphodiesterase, resulting in increased intracellular cyclic AMP [14, 25], suggesting that these compound as well as Gardenia act synergistically to increase cyclic AMP signaling and downstream upregulation of UCP1 expression in brown adipose tissue. Emodin, one of the active anthraquinone derivatives in Rhubarb, inhibits production of TNF-α and tyrosine kinase activity [37].…”

Characteristics of Beige Adipocytes Induced from White Adipocytes by <i>Kikyo</i> Extract

“…For instance, the expression of the UCP1 gene was increased by the intake of rosiglitazone, an antagonist of PPARγ [31], and long-term stimulation by exercise was effective in increasing the ratio of UCP1 [18]. With respect to Chinese herbal medicines, bofu-tsusho-san was effective in enhancing the secretion of adrenaline, as well as nonshivering thermogenesis, according to experiments using mice [32]- [34]. However, no effective compounds inducing the production of beige adipocytes such as kikyo extract had yet been identified.…”

Systematic Review on Herbal Treatment for Obesity in Adults

“…최종적으로 선정된 13편의 무작위 대조군 임상연구에 서 사용한 한약은 방풍통성산과 위약을 비교한 임상연구 4편 [9][10][11][12] , 태음조위탕 2편 13,14) , 방기황기탕 1편 15) , 방풍통성 산과 방기황기탕을 각각의 군에 배정한 논문 1편이었다 16) .…”