Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia

Gururajan, Anand; Taylor, David A.; Malone, Daniel Thomas

doi:10.1016/j.bbr.2011.03.053

Cited by 77 publications

(95 citation statements)

References 52 publications

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“…In agreement with this possibility, Long and colleagues (2006) found that CBD (5 mg/kg), similar to clozapine (4 mg/kg), reversed the PPI impairment induced by MK-801 (1 mg/kg). Since it also improved the reduced social interaction caused by this treatment, it was suggested that CBD could attenuate both the positive and negative symptoms of schizophrenia (Long et al 2006;Gururajan et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine

et al. 2015

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“…Preclinical studies have shown that CBD also exhibits a profile that is similar to atypical antipsychotic drugs. Cannabidiol reduced stereotyped behavior (Zuardi et al, 1991), reversed the disruption of prepulse inhibition (Long et al, 2006;Gururajan et al, 2011), and restored MK-801-induced behavioral deficits in the social interaction and novel object recognition tests (Gomes et al, 2015). In the clinical setting, CBD attenuated some aspects of schizophrenia without producing extrapyramidal side effects (Zuardi et al, 1995;Zuardi et al, 2006;Leweke et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon

Bonato

Milani

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

109

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“…A common variation includes the addition of more prepulse intensities ranging from 3 db above background noise to 20 db above noise. Also, the habituation block can be split into a short block of 5-10 stimuli before the PPI block, plus a third block of 5-10 stimuli after the PPI block [18][19][20] . A thorough study of the existing literature before designing a testing protocol is therefore essential.…”

Section: Variations Of the Testing Protocolmentioning

confidence: 99%

“…Animals sensitize if a stimulus is aversive, thus too loud startle stimuli should be avoided for habituation measurements, for review see 27 . Stress, anxiety and fear do also increase startle responses 28 ,oppose habituation and affect PPI 18 . Animals should therefore be well handled and acclimatized to the startle testing apparatus.…”

Section: Habituation Versus Sensitizationmentioning

confidence: 99%

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Valsamis

Schmid

2011

JoVE

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The acoustic startle response is a protective response, elicited by a sudden and intense acoustic stimulus. Facial and skeletal muscles are activated within a few milliseconds, leading to a whole body flinch in rodents 1 . Although startle responses are reflexive responses that can be reliably elicited, they are not stereotypic. They can be modulated by emotions such as fear (fear potentiated startle) and joy (joy attenuated startle), by non-associative learning processes such as habituation and sensitization, and by other sensory stimuli through sensory gating processes (prepulse inhibition), turning startle responses into an excellent tool for assessing emotions, learning, and sensory gating, for review see 2,3 . The primary pathway mediating startle responses is very short and well described, qualifying startle also as an excellent model for studying the underlying mechanisms for behavioural plasticity on a cellular/molecular level 3 .We here describe a method for assessing short-term habituation, long-term habituation and prepulse inhibition of acoustic startle responses in rodents. Habituation describes the decrease of the startle response magnitude upon repeated presentation of the same stimulus. Habituation within a testing session is called short-term habituation (STH) and is reversible upon a period of several minutes without stimulation. Habituation between testing sessions is called long-term habituation (LTH) 4 . Habituation is stimulus specific 5 . Prepulse inhibition is the attenuation of a startle response by a preceding non-startling sensory stimulus 6 . The interval between prepulse and startle stimulus can vary from 6 to up to 2000 ms. The prepulse can be any modality, however, acoustic prepulses are the most commonly used.Habituation is a form of non-associative learning. It can also be viewed as a form of sensory filtering, since it reduces the organisms' response to a non-threatening stimulus. Prepulse inhibition (PPI) was originally developed in human neuropsychiatric research as an operational measure for sensory gating 7

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Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia

Cited by 77 publications

References 52 publications

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

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