Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon, Angélica Pupin; Bonato, Jéssica Mendes; Milani, Humberto; Guimarães, Francisco Silveira; Oliveira, Rúbia Maria Weffort de

doi:10.1016/j.pnpbp.2015.06.017

Cited by 110 publications

(106 citation statements)

References 72 publications

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“…Systemic CBD treatment reduced immobility time in mice, as did the prototype tricyclic antidepressant imipramine (Zanelati et al, 2010). Similar results were shown in mice submitted to the FST or the tail suspension test (TST) (El-Alfya et al, 2010; Réus et al, 2011; Schiavon et al, 2016). More recently, the antidepressant-like effect of CBD was detected in the olfactory bulbectomy (Linge et al, 2016) and learned helplessness models (Pereira et al, 2016).…”

Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disorderssupporting

confidence: 69%

“…To explain these findings, the authors suggested that the CBD neuroprotective effects would occur through a mechanism that facilitates hippocampal neurogenesis (Demirakca et al, 2011). However, as will be discussed bellow, the role of neurogenesis in CBD effects is complex and may depend on the stress level (Schiavon et al, 2016). …”

Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disordersmentioning

confidence: 99%

“…At a lower dose, CBD decreased depressive-like behaviors in non-stressed Swiss mice in the TST and increased the number of Ki67, BrdU, and doublecortin-positive cells, reflecting an enhanced SGZ neurogenesis (Schiavon et al, 2016). In this study, however, a higher CBD dose, despite still displaying an antidepressant-like effect, decreased the number of positive cell markers for the neurogenesis in the hippocampus (Schiavon et al, 2016). More studies, therefore, are needed to unveil an involvement of hippocampal neurogenesis in the antidepressive-like effects of CBD.…”

Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disordersmentioning

confidence: 99%

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Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

et al. 2017

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Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood. Similar to clinical antidepressant or atypical antipsychotic drugs, recent findings clearly indicate that CBD, either acutely or repeatedly administered, induces plastic changes. For example, CBD attenuates the decrease in hippocampal neurogenesis and dendrite spines density induced by chronic stress and prevents microglia activation and the decrease in the number of parvalbumin-positive GABA neurons in a pharmacological model of schizophrenia. More recently, it was found that CBD modulates cell fate regulatory pathways such as autophagy and others critical pathways for neuronal survival in neurodegenerative experimental models, suggesting the potential benefit of CBD treatment for psychiatric/cognitive symptoms associated with neurodegeneration. These changes and their possible association with CBD beneficial effects in psychiatric disorders are reviewed here.

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Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disorderssupporting

confidence: 69%

Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disordersmentioning

confidence: 99%

Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disordersmentioning

confidence: 99%

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Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

et al. 2017

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“…Given the current trends in cannabinoid research, combining THC with cannabidiol may work to reduce these deficits. Cannabidiol is recognized for its lack of psychoactive effects, stimulation of hippocampal cell proliferation and neurogenesis, and has been demonstrated to reduce novel object memory impairment in other models that produce neuroinflammation (Pertwee, 2008; Fagherazzi et al, 2012; Fishbein-Kaminietsky et al, 2014; Campos et al, 2015; Schiavon et al, 2016). With the use of medical cannabis on the rise, it is important to understand how the addition of cannabidiol to THC may mediate negative side effects.…”

Section: Discussionmentioning

confidence: 99%

Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Kasten

Zhang

Boehm

2017

Pharmacology Biochemistry and Behavior

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Use of exogenous cannabinoids disrupts the fine-tuned endocannabinoid receptor system, possibly leading to alterations in cognition, memory, and emotional processes that endure long after cannabinoid use has stopped. Long-term adolescent use may uniquely disrupt these behaviors when compared to adult use. The current study explored the acute and long-term behavioral effects of six 10 mg/kg Δ9-tetrahydrocannabinol (THC) injections across the adolescent or early adult period in male inbred C57Bl/6J and DBA/2J mice. The acute and prolonged effects of THC on object memory using the novel object recognition task, unconditioned anxiety in the elevated plus maze and open field, and sedative effects in the open field were examined. Acute THC treatment resulted in anxiogenic activity in both strains, but only caused sedation in B6 mice. Repeated THC treatment resulted in a protracted effect on object recognition, but not unconditioned anxiety, assessed 4 weeks later. In both strains, an adolescent history of THC treatment disrupted later object recognition. Interestingly, in B6 mice an adult history of THC exposure appeared to rescue a deficit in object recognition observed in vehicle-treated adults. Repeated THC administration also produced a protracted effected on CB1R protein expression. Animals treated with THC in adolescence maintained increased levels of CB1R protein expression compared to their adult THC-treated counterparts at five weeks following the last injection. These results indicate that THC use may have long-lasting effects with adolescence being a unique period of susceptibility.

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“…In this regard, several preclinical studies have revealed the pro-neurogenic effects of CBD in the hippocampus and the subventricular zone (Campos et al, 2013;Schiavon et al, 2016;Wolf et al, 2010). One study identified that this effect is mediated by CBD acting as a ligand at the peroxisome proliferator-activated receptor-γ (PPARγ) (Esposito et al, 2011).…”

Section: Potential Mechanisms Of Antipsychotic Effectmentioning

confidence: 99%

Does cannabidiol have a role in the treatment of schizophrenia?

Gururajan

Malone

2016

Schizophrenia Research

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Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Cited by 110 publications

References 72 publications

Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

Acute and long-term effects of Δ9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice

Does cannabidiol have a role in the treatment of schizophrenia?

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