2016
DOI: 10.1016/j.pnpbp.2015.06.017
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Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

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Cited by 115 publications
(116 citation statements)
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“…Systemic CBD treatment reduced immobility time in mice, as did the prototype tricyclic antidepressant imipramine (Zanelati et al, 2010). Similar results were shown in mice submitted to the FST or the tail suspension test (TST) (El-Alfya et al, 2010; Réus et al, 2011; Schiavon et al, 2016). More recently, the antidepressant-like effect of CBD was detected in the olfactory bulbectomy (Linge et al, 2016) and learned helplessness models (Pereira et al, 2016).…”
Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disorderssupporting
confidence: 69%
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“…Systemic CBD treatment reduced immobility time in mice, as did the prototype tricyclic antidepressant imipramine (Zanelati et al, 2010). Similar results were shown in mice submitted to the FST or the tail suspension test (TST) (El-Alfya et al, 2010; Réus et al, 2011; Schiavon et al, 2016). More recently, the antidepressant-like effect of CBD was detected in the olfactory bulbectomy (Linge et al, 2016) and learned helplessness models (Pereira et al, 2016).…”
Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disorderssupporting
confidence: 69%
“…To explain these findings, the authors suggested that the CBD neuroprotective effects would occur through a mechanism that facilitates hippocampal neurogenesis (Demirakca et al, 2011). However, as will be discussed bellow, the role of neurogenesis in CBD effects is complex and may depend on the stress level (Schiavon et al, 2016). …”
Section: Mechanisms Of Cbd Effects In Neuropsychiatric Disordersmentioning
confidence: 99%
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“…Given the current trends in cannabinoid research, combining THC with cannabidiol may work to reduce these deficits. Cannabidiol is recognized for its lack of psychoactive effects, stimulation of hippocampal cell proliferation and neurogenesis, and has been demonstrated to reduce novel object memory impairment in other models that produce neuroinflammation (Pertwee, 2008; Fagherazzi et al, 2012; Fishbein-Kaminietsky et al, 2014; Campos et al, 2015; Schiavon et al, 2016). With the use of medical cannabis on the rise, it is important to understand how the addition of cannabidiol to THC may mediate negative side effects.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, several preclinical studies have revealed the pro-neurogenic effects of CBD in the hippocampus and the subventricular zone (Campos et al, 2013;Schiavon et al, 2016;Wolf et al, 2010). One study identified that this effect is mediated by CBD acting as a ligand at the peroxisome proliferator-activated receptor-γ (PPARγ) (Esposito et al, 2011).…”
Section: Potential Mechanisms Of Antipsychotic Effectmentioning
confidence: 99%