Effect of camel milk on blood glucose, cholesterol and total proteins variations in alloxan-induced diabetic dogs

Abstract

_________________________________________________________________________________________ AbstractThe efficacy of camel milk on alloxan-induced diabetic dogs was evaluated in this study. Firstly, two diabetic groups of dogs received raw camel milk (group1) or raw cow milk (group 2). One healthy group was used as control in which dogs received raw camel milk. Five hundred ml of raw milk were given to the animals daily for five weeks. By the end of the first test, group1 showed a statistically significant decline in blood glucose (from 10.88±0.55 mmol/l to 5.77±0.44 mmol/l); cholesterol (from 5.99±0.15 mmol/l to 4.4±0.62 mmol/l) and in total proteins concentrations (from 80.06 ± 2.11 g/l to 63.56 ± 3.16 g/l). In this period, group 2 showed high blood glucose (8 mmol/l), cholesterol (from 5.99±0.58 to 7.13±1.25 mmol/l) and total proteins concentrations (from 79.18±6.07 to 84.33±0.56 g/l). This diabetic state was confirmed by Intraperitoneal glucose tolerance test. These dogs (group 2) were treated, in test 2, with camel milk instead of bovine milk and showed an improvement in blood glucose (from 9.83±0.72 mmol/l before drinking milk to 7.83±0.88 mmol/l in week 4), proteins and lipids profiles. Dogs from group1, which were used to follow the effect of camel milk by the end of experiment, showed healthy state: normal blood glucose levels (5.16-6.5mmol/l), cholesterol (4.14-5.51mmol/l), triglycerides(0.51-1.21mmol/l) and total proteins concentrations (60.77-69.18 g/l). It is obvious in this study that camel milk has a therapeutic effect on alloxan-induced diabetic dogs.

Camel Milk Has Beneficial Effects on Diabetes Mellitus: A Systematic Review

“…After 5 weeks, blood glucose and cholesterol concentration significantly decreased in the camel milk receiving diabetic group, but increased in the cow milk diabetic group, alterations observed even after 3 weeks of intervention. The control group showed no significant difference in the mentioned parameters after the intervention period; results also showed that substituting cow milk with camel milk in the cow milk diabetic group led to significant improvement in blood glucose (from 10.88 ± 0.50 to 5.77 ± 0.44 mM/L, P value < 0.05) and cholesterol status (from 6.17 ± 0.15 to 4.35 ± 0.61 mM/L, P value < 0.05) after 4 weeks ( 21 ). In the other study, Sboui et al compared the anti-diabetic effect of 3 amounts of camel milk: 100, 250, and 500 mL on alloxan- induced diabetic dogs.…”

Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats

“…The significant decrease in blood glucose level in diabetic rats treated with camel milk could be due to the reported high levels of insulin or insulin like protein in camel milk (Farah 1993;Agrawal et al, 2003). Other studies attributed hypoglycaemic effect of camel milk by its potential to either increase the effect of insulin or by increasing the release of insulin from the pancreatic beta-cells (Sboui et al, 2010).…”

Influence of management type and stage of lactation on the performance and milk fatty acid profile of dairy camels (Camelus dromedaries)

“…The observed depression of milk fat at mid-lactation herein consequently contradicts such a tentative recommendation. In fact, camels’ milk appears to be healthier for human consumption in terms of levels of VA, RA, unsaturated fatty acids and health-promoting indices, when compared to those observed in cows’, ewes’ or goats’ milk produced under similar circumstances (McGuire and McGuire, 2000; Agrawal et al 2005, Sboui et al 2010; Abrhaley and Leta, 2018).…”

“…Camel milk has actually been proposed as a beneficial substitute for humans’ and cows’ milk for premature new-born and milk-allergic children because of the lack of β-lactoglobulin and beta casein, in addition to its comparably smaller nanobodies (Shabo et al 2005; Zafra et al 2011). Furthermore, a considerable amount of research has been published indicating the potential therapeutic employment of camel milk for treating many dysfunctions and autoimmune diseases such as diabetes mellitus, hypercholesterolemia, obesity, atherosclerosis, oxidative stress, hepatitis B, Crohn's disease, autism and cancer (Corl et al 2003; Lock & Bauman, 2004; Agrawal et al 2005, Sboui et al 2010; Diaz-Medina et al 2016; Abrhaley and Leta, 2018), which reflects a growing interest in utilizing camels’ milk for human nutrition.…”